{"uid":"cap_yjuxtE4V1ZKgkRSKqQJ0M","slug":"compound-target-mechanism-of-action-lookup-a9a98e21","name":"Compound Target & Mechanism of Action Lookup","description":"Find a compound’s protein targets and mechanisms of action, with supporting references.","url":"https://win.oneshotagent.com/v1/tools/lookup/compound-targets?utm_source=zero.xyz","method":"POST","headers":{},"bodySchema":{"type":"object","properties":{"name":{"type":"string","description":"Drug or compound name; the first search hit is used. 2 to 100 characters."},"chembl_id":{"type":"string","description":"ChEMBL molecule identifier; lowercase is accepted. CHEMBL followed by 1 to 9 digits, without a leading zero."}}},"responseSchema":{"type":"json","example":{"name":"ADALIMUMAB","matched":true,"chembl_id":"CHEMBL1201580","drug_type":"Antibody","candidates":[],"mechanisms":[{"targets":[{"symbol":"TNF","ensembl_gene_id":"ENSG00000232810"}],"mechanism":"TNF-alpha inhibitor","references":[{"urls":["http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=608d4f0d-b19f-46d3-749a-7159aa5f933d"],"source":"DailyMed"}],"action_type":"INHIBITOR","target_name":"Tumor necrosis factor"}],"action_types":["INHIBITOR"],"target_types":["single protein"],"max_clinical_stage":"APPROVAL"}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_vDZfr1x85vMN23T1kDNCH","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Given a drug or compound name or ChEMBL ID, returns its protein targets, mechanisms of action, action types, and supporting biomedical references.","exampleAgentPrompt":"What proteins does adalimumab target and what is its mechanism of action? Look it up by compound name and give me the gene symbols, target names, and any supporting references.","exampleUseCases":[{"title":"Drug repurposing target analysis","prompt":"I'm researching whether metformin could be repurposed for cancer treatment — can you look up all its known protein targets and mechanisms of action, including the gene symbols and action types?"},{"title":"Biomedical literature enrichment","prompt":"For the compound with ChEMBL ID CHEMBL25, what are the molecular targets and mechanisms of action? I need the target gene symbols, action types, and reference URLs so I can cite them."},{"title":"Competitive drug landscape research","prompt":"Can you find the protein targets and mechanism of action for pembrolizumab, including what clinical stage it has reached and whether it's been approved?"}],"resultDescription":"Returns a JSON object with the matched compound's canonical name, ChEMBL ID, drug type, mechanisms of action (each with target gene symbols, Ensembl gene IDs, target name, action type, and DailyMed or other reference URLs), a list of all action types, target types, and the maximum clinical stage reached (e.g. APPROVAL).","failureModes":["Compound name not found in ChEMBL — matched:false with empty mechanisms array","Ambiguous compound name resolves to unintended first search hit","ChEMBL ID format invalid — rejected before lookup","No mechanism data available for a known compound — empty mechanisms array","Rate limiting or payment failure due to x402 protocol issues"],"whenToPreferThis":"Choose this endpoint when you need structured, reference-backed protein target and mechanism-of-action data for a specific drug or compound, especially when you have a compound name or ChEMBL ID and need downstream pharmacological analysis. Prefer it over general web search when you need machine-readable output with gene symbols and citations rather than prose descriptions.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-10-25T12:31:24.547Z","isFirstParty":false,"canonicalSlug":"compound-target-mechanism-of-action-lookup-a9a98e21"}