{"uid":"cap_wdKQN6Jw3k0X5S2Krp4Nl","slug":"iwg-2-typical-alzheimer-s-disease-criteria-calculator-dubois-2014-05879d17","name":"IWG-2 Typical Alzheimer's Disease Criteria Calculator (Dubois 2014)","description":"Dubois 2014 IWG-2 typical AD research criteria. typical_ad iff early hippocampal-type episodic memory, no better explanation, and in-vivo AD pathology (CSF Abeta1-42 plus T-tau or P-tau, amyloid PET, or a PSEN1/PSEN2/APP mutation). Typical AD only; not atypical phenotypes. Not NINCDS-ADRDA, not NIA-AA ATN, not DSM. magent does not examine the patient, assay CSF, or read PET. Not a diagnosis or medical device.","url":"https://api.magentlab.com/api/calc/iwg2_ad","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["early_episodic_memory","csf_abeta_and_tau","amyloid_pet","autosomal_dominant_mutation","no_better_explanation"],"properties":{"amyloid_pet":{"type":"boolean","description":"Increased tracer retention on amyloid PET, as assigned by the caller (Dubois 2014 IWG-2 in-vivo AD pathology). true or false. magent does not read PET."},"csf_abeta_and_tau":{"type":"boolean","description":"Decreased Aβ1-42 together with increased T-tau or P-tau in CSF, as assigned by the caller (Dubois 2014 IWG-2 in-vivo AD pathology). true or false. magent does not assay CSF."},"early_episodic_memory":{"type":"boolean","description":"Early and significant episodic memory impairment of the hippocampal type (IWG-2 specific phenotype for typical AD), as assigned by the caller. true or false. magent does not examine the patient."},"no_better_explanation":{"type":"boolean","description":"Exclusion of other disorders that could account for the phenotype, as assigned by the caller (Dubois 2014 IWG-2). true or false. magent does not examine the patient."},"autosomal_dominant_mutation":{"type":"boolean","description":"Proven AD autosomal-dominant mutation in PSEN1, PSEN2, or APP, as assigned by the caller (Dubois 2014 IWG-2 in-vivo AD pathology). true or false. magent does not sequence genes."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_nYY1kuw65PVdKppb8Bifc","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Applies the Dubois 2014 IWG-2 criteria to determine whether a patient meets the definition of typical Alzheimer's disease based on caller-supplied clinical flags.","exampleAgentPrompt":"Check if this patient meets IWG-2 typical Alzheimer's disease criteria: they have early hippocampal-type episodic memory impairment, positive CSF Abeta1-42 plus tau results, negative amyloid PET, no autosomal dominant mutation, and no better explanation for the symptoms.","exampleUseCases":[{"title":"Research cohort AD eligibility screening","prompt":"I need to check if this research participant qualifies as typical AD under Dubois 2014 IWG-2: they have early hippocampal-type episodic memory impairment, their CSF shows decreased Abeta1-42 and elevated tau, amyloid PET is negative, no PSEN1/PSEN2/APP mutation confirmed, and no better explanation for the presentation."},{"title":"Clinical trial enrollment decision support","prompt":"Can you run the IWG-2 typical AD check for a patient being considered for a trial? They have early episodic memory impairment of hippocampal type, their amyloid PET is positive, CSF biomarkers are not available, no autosomal dominant mutation found, and other diagnoses have been excluded."},{"title":"Automated AD classification in EHR pipeline","prompt":"For this patient record, apply the 2014 Dubois IWG-2 criteria: early hippocampal episodic memory impairment is true, CSF Abeta1-42 plus tau is false, amyloid PET is false, autosomal dominant mutation is true, and no better explanation is true — do they meet typical AD?"}],"resultDescription":"Returns a boolean classification indicating whether the patient meets the Dubois 2014 IWG-2 definition of typical Alzheimer's disease (typical_ad: true/false), based on the five caller-supplied flags: early hippocampal-type episodic memory impairment, CSF Abeta/tau pathology, amyloid PET positivity, autosomal dominant mutation, and absence of a better explanation.","failureModes":["Missing required query parameters (early_episodic_memory, csf_abeta_and_tau, amyloid_pet, autosomal_dominant_mutation, no_better_explanation) returns an error","Non-boolean values for any flag cause a validation error","Atypical AD phenotypes are outside scope and will not be correctly classified","Endpoint cannot generate or verify the underlying clinical data — garbage-in, garbage-out if flags are incorrectly assigned by the caller"],"whenToPreferThis":"Use this endpoint when you need to programmatically apply the specific Dubois 2014 IWG-2 criteria for typical Alzheimer's disease — not NIA-AA ATN, not NINCDS-ADRDA, not DSM. Ideal for research pipelines, clinical trial screening workflows, or EHR automation where a clinician or upstream system has already assigned the five binary clinical flags and you need a rule-based IWG-2 classification without manual lookup.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-15T07:08:22.872Z","isFirstParty":false}