{"uid":"cap_veARDM1lcd6-08M2jAktK","slug":"flipi24-24-month-event-probability-calculator-maurer-2025-54a4c97b","name":"FLIPI24 24-Month Event Probability Calculator (Maurer 2025)","description":"Maurer 2025 FLIPI24: 24-month event probability in newly diagnosed follicular lymphoma from age (nonlinear, inflection at 75), hemoglobin, WBC, LDH/ULN, and beta-2 microglobulin. Table S5 Cox algorithm assuming R-CHOP or B-R-like immunochemotherapy and 50% anti-CD20 maintenance. Low/intermediate/high at 0.10 and 0.15. Not Solal-Céligny FLIPI 2004. Not a diagnosis or treatment order. magent does not assay labs.","url":"https://api.magentlab.com/api/calc/flipi24","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["age","hemoglobin_g_dl","wbc_10e9_l","ldh_uln_ratio","b2m_mg_l"],"properties":{"age":{"type":"integer","description":"Age in years (integer 18-120). Maurer 2025 Table S5: no additional age effect 18-60; HR 1.01 per year 60-75 (beta 0.01); HR 1.05 per year 75-90 (extra beta 0.038). Age is clamped to 90 for the linear predictor. magent does not assign age."},"b2m_mg_l":{"type":"number","description":"Beta-2 microglobulin in mg/L (0.1-40). Table S5 linear 1-10 mg/L, HR 1.17 per unit (beta 0.159); values outside 1-10 are clamped. magent does not assay B2M."},"wbc_10e9_l":{"type":"number","description":"White blood cell count in 10^9/L (0.1-80), equal to k/µL. Table S5 linear 4-11, HR 1.08 per unit (beta 0.075); values outside 4-11 are clamped. magent does not assay WBC."},"ldh_uln_ratio":{"type":"number","description":"Caller-assigned serum LDH divided by the local upper limit of normal (0.1-20). Table S5 linear 0.5-5, HR 1.44 per unit (beta 0.364); values outside 0.5-5 are clamped. magent does not measure LDH or set the ULN."},"hemoglobin_g_dl":{"type":"number","description":"Hemoglobin in g/dL (1-25). Table S5 linear 8-17 g/dL, HR 0.92 per unit (beta -0.081); values outside 8-17 are clamped. magent does not assay hemoglobin."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_MhdUtGqVxwi8FAGf28mk1","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes 24-month event probability for newly diagnosed follicular lymphoma using the Maurer 2025 FLIPI24 Cox model (Table S5) from age, hemoglobin, WBC, LDH/ULN ratio, and beta-2 microglobulin, with low/intermediate/high risk strata.","exampleAgentPrompt":"Using the Maurer 2025 FLIPI24 model, calculate the 24-month event probability for a 68-year-old follicular lymphoma patient with hemoglobin 11.2 g/dL, WBC 7.4 (10^9/L), LDH/ULN ratio 1.3, and beta-2 microglobulin 3.8 mg/L — and tell me their risk stratum.","exampleUseCases":[{"title":"Pre-treatment FL risk stratification","prompt":"My newly diagnosed follicular lymphoma patient is 72 years old, hemoglobin is 9.8 g/dL, WBC is 10.1 (10^9/L), LDH/ULN ratio is 1.8, and B2M is 4.5 mg/L — run the FLIPI24 model and tell me if they're low, intermediate, or high risk before we start immunochemotherapy."},{"title":"Clinical trial enrollment triage","prompt":"We need FLIPI24 risk strata for a trial screening: the patient is 58 years old, hemoglobin 13.4 g/dL, WBC 5.2, LDH/ULN 0.9, and beta-2 microglobulin 2.1 mg/L. What's the 24-month event probability and Maurer 2025 risk category?"},{"title":"High-risk FL patient identification","prompt":"Can you flag whether this FL patient is high risk per FLIPI24? They're 80 years old, hemoglobin 8.5 g/dL, WBC 11.5, LDH/ULN ratio 2.6, and B2M is 6.2 mg/L — assuming they'll be treated with R-CHOP plus maintenance."}],"resultDescription":"Returns a 24-month event probability (numeric, 0–1) and a risk stratum classification (low, intermediate, or high) based on the Maurer 2025 Table S5 Cox proportional hazards model, calibrated for patients receiving R-CHOP or bendamustine-rituximab-like immunochemotherapy with ~50% anti-CD20 maintenance. Risk strata use thresholds of 0.10 and 0.15.","failureModes":["Missing required query parameter (age, hemoglobin_g_dl, wbc_10e9_l, ldh_uln_ratio, or b2m_mg_l) returns 400 error","Age outside 18–120 or numeric values outside valid ranges may be rejected or clamped depending on implementation","Non-integer age value may cause validation error","Payment not provided or invalid x402 payment header results in 402 Payment Required","Server-side error returns 500 with no probability output"],"whenToPreferThis":"Use this endpoint when you need the Maurer 2025 FLIPI24 prognostic score specifically — distinct from the original Solal-Céligny FLIPI 2004 — for newly diagnosed follicular lymphoma patients being considered for R-CHOP or bendamustine-rituximab immunochemotherapy. Prefer this over generic FLIPI calculators when the nonlinear age effect (inflection at 75) and beta-2 microglobulin are clinically relevant and lab values are already known.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T06:41:56.811Z","isFirstParty":false}