{"uid":"cap_vQ4jBXkBkDeDW0j6bqOGZ","slug":"hfa-icos-raf-mek-inhibitor-baseline-cardiovascular-risk-calculator-cc8ee00d","name":"HFA-ICOS RAF/MEK Inhibitor Baseline Cardiovascular Risk Calculator","description":"Lyon 2020 HFA-ICOS baseline CV risk before combination RAF and MEK inhibitors. Very high if heart failure or cardiomyopathy; High if MI/CABG, stable angina, severe valvular disease, prior anthracycline, or ≥5 medium points; Medium if 2-4 medium points; Low if 0-1. Age ≥65 is Medium 1 only. LVEF 50-54 is Medium 2; this table has no printed LVEF <50 High row. Expert-opinion cardiotoxicity guide <2% / 2-9% / 10-19% / ≥20%. Not a treatment order.","url":"https://api.magentlab.com/api/calc/hfa_icos_raf_mek","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["age_years","lvef_percent","heart_failure_or_cardiomyopathy","mi_or_cabg","stable_angina","severe_valvular_heart_disease","prior_anthracycline","elevated_troponin","elevated_bnp","hypertension","prior_left_chest_or_mediastinal_rt","arrhythmia","diabetes","ckd","current_or_significant_smoker","obesity"],"properties":{"ckd":{"type":"boolean","description":"Chronic kidney disease (estimated glomerular filtration rate <60 mL/min/1.73 m2) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1. magent does not compute eGFR."},"obesity":{"type":"boolean","description":"Obesity (BMI >30 kg/m2) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1. magent does not compute BMI."},"diabetes":{"type":"boolean","description":"Diabetes mellitus (glycated haemoglobin >7.0% or >53 mmol/mol, or on treatment) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1. magent does not assay haemoglobin A1c."},"age_years":{"type":"integer","description":"Age in whole years (18-100). Lyon 2020 RAF-MEK table: age ≥65 is Medium 1. There is no High age band on this table. magent does not read an identity document."},"arrhythmia":{"type":"boolean","description":"Atrial fibrillation, atrial flutter, ventricular tachycardia, or ventricular fibrillation as assigned by the caller (Lyon 2020 RAF-MEK table footnote). true is Medium 1. magent does not read an ECG."},"mi_or_cabg":{"type":"boolean","description":"Myocardial infarction or CABG as assigned by the caller (Lyon 2020 RAF-MEK table). true is High."},"elevated_bnp":{"type":"boolean","description":"Elevated baseline BNP or NT-proBNP above the local laboratory upper limit of normal as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 2. magent does not assay natriuretic peptides."},"hypertension":{"type":"boolean","description":"Hypertension (systolic >140 mm Hg or diastolic >90 mm Hg, or on treatment) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 2. magent does not measure blood pressure."},"lvef_percent":{"type":"integer","description":"Baseline LVEF in whole percent (10-80) as assigned by the caller. 50-54 is Medium 2. ≥55 adds no points. This table has no printed LVEF <50 High row; LVEF <50 does not raise risk_level by itself. magent does not read an echocardiogram."},"stable_angina":{"type":"boolean","description":"Stable angina as assigned by the caller (Lyon 2020 RAF-MEK table). true is High. magent does not diagnose angina."},"elevated_troponin":{"type":"boolean","description":"Elevated baseline troponin above the local laboratory upper limit of normal as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 2. magent does not assay troponin."},"prior_anthracycline":{"type":"boolean","description":"Prior anthracycline exposure as assigned by the caller (Lyon 2020 RAF-MEK table). true is High. magent does not read a chemotherapy record."},"current_or_significant_smoker":{"type":"boolean","description":"Current smoker or significant smoking history as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1."},"severe_valvular_heart_disease":{"type":"boolean","description":"Severe valvular heart disease as assigned by the caller (Lyon 2020 RAF-MEK table). true is High."},"heart_failure_or_cardiomyopathy":{"type":"boolean","description":"Heart failure or cardiomyopathy as assigned by the caller (Lyon 2020 RAF-MEK table). true is Very high. magent does not diagnose heart failure."},"prior_left_chest_or_mediastinal_rt":{"type":"boolean","description":"Prior radiotherapy to the left chest or mediastinum as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 2."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_aL1OIYBlQ7cnLzt1qx_rH","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Classifies a patient's baseline cardiovascular risk (Very High / High / Medium / Low) before starting RAF and MEK inhibitor therapy, using the Lyon 2020 HFA-ICOS framework.","exampleAgentPrompt":"My patient is 68 years old with an LVEF of 52%, a history of prior anthracycline use, hypertension, and diabetes — no heart failure, MI, CABG, angina, valvular disease, arrhythmia, elevated troponin, elevated BNP, prior chest radiation, CKD, significant smoking, or obesity. What is their HFA-ICOS baseline cardiovascular risk category before we start a RAF and MEK inhibitor combination?","exampleUseCases":[{"title":"Pre-RAF/MEK therapy cardiac triage","prompt":"My melanoma patient is 72 years old, LVEF 55%, with a past MI, no heart failure, no prior anthracyclines, has hypertension and type 2 diabetes (HbA1c well above 7%), no CKD, no arrhythmia, no prior chest radiation, no elevated troponin or BNP, not obese, not a smoker, and no significant angina or valvular disease — can you give me the Lyon 2020 HFA-ICOS cardiovascular risk classification before I start them on a RAF plus MEK inhibitor?"},{"title":"Borderline LVEF pre-treatment risk check","prompt":"I have a 58-year-old patient with an LVEF of 52%, no cardiac history, no anthracycline exposure, no arrhythmia, no elevated troponin or BNP, no prior chest radiation, no hypertension, no diabetes, no CKD, not obese, and a non-smoker — what HFA-ICOS CV risk tier do they fall into before starting RAF and MEK inhibitors?"},{"title":"High-burden comorbidity stratification","prompt":"Before we initiate combination RAF and MEK inhibitor therapy, classify the cardiac risk for a 61-year-old with a BMI of 33 (obese), CKD with eGFR below 60, atrial fibrillation, elevated BNP at baseline, no heart failure, no MI or CABG, no anthracyclines, LVEF of 58%, not a smoker, no diabetes, no hypertension, no prior radiation, and no valvular disease or angina."}],"resultDescription":"Returns a categorical cardiovascular risk classification (Very High, High, Medium, or Low) based on the Lyon 2020 HFA-ICOS RAF/MEK table, along with the count of medium-risk points accumulated and a corresponding expert-opinion cardiotoxicity probability band (<2%, 2–9%, 10–19%, or ≥20%). This is an informational risk stratification output, not a treatment order.","failureModes":["Missing required boolean parameters returns a validation error","Age outside 18–100 range is rejected","LVEF values outside expected range may not be handled","Ambiguous or non-boolean inputs for flag fields cause schema errors","Network timeout or upstream server error returns a 5xx response","Payment not included or insufficient returns a 402 Payment Required error"],"whenToPreferThis":"Use this endpoint when you need to apply the specific Lyon 2020 HFA-ICOS cardiotoxicity risk classification framework for patients being considered for RAF and/or MEK inhibitor combination therapy. It implements the exact risk table with Very High / High / Medium / Low tiers and medium-point counting. Prefer this over generic cardiovascular risk calculators (e.g., Framingham, SCORE) when the clinical question is specifically about cardiotoxicity risk before targeted cancer therapy, not general population ASCVD risk.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T13:04:05.248Z","isFirstParty":false}