{"uid":"cap_sU-bBmvLGspfCVFU514nC","slug":"saylor-innovations-bioinformatics-genetic-variant-clinical-5f629881","name":"Saylor Innovations Bioinformatics — Genetic Variant Clinical Significance (ClinVar)","description":"Genetic Variant Clinical Significance (ClinVar). Genetic variant clinical significance from ClinVar by rsID, ClinVar id (VCV) or HGVS: pathogenic / benign / uncertain classification, review status with 0-4 stars, conditions, genes, molecular consequence, protein change and last evaluated date, best-reviewed record first. NCBI ClinVar, public domain; not medical advice.","url":"https://saylorinnovations.com/api/bio/variant/:id?utm_source=zero.xyz","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method","pathParams"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","POST","PUT","PATCH","DELETE","HEAD"],"type":"string"},"pathParams":{"type":"object","required":["id"],"properties":{"id":{"type":"string"}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string","const":"json"},"example":{"type":"object","required":["found"],"properties":{"found":{"type":"boolean"},"primary":{"type":"object"},"records":{"type":"array","items":{"type":"object"}}}}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.003","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.003/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.003","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.003","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_LkN6jeO1QWnlc5hYDSrvN","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.003","costPer":"request","priority":0,"asset":"EPjFWdd5AufqSSqeM2qN1xzybapC8G4wEGGkZwyTDt1v","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Returns clinical significance, review status, conditions, genes, and molecular details for a genetic variant queried by rsID, ClinVar VCV ID, or HGVS notation, sourced from NCBI ClinVar.","exampleAgentPrompt":"Look up the clinical significance of the genetic variant rs121912666 in ClinVar — I need the pathogenicity classification, review star rating, associated conditions, and any protein change noted.","exampleUseCases":[{"title":"Variant pathogenicity check for genetic counseling","prompt":"Can you look up rs80357713 in ClinVar and tell me if it's classified as pathogenic, benign, or uncertain, along with which conditions it's linked to and the review star rating?"},{"title":"HGVS variant annotation for research pipeline","prompt":"I have the HGVS notation NM_007294.4:c.5266dupC — can you pull its ClinVar entry and give me the clinical significance, molecular consequence, and last evaluated date?"},{"title":"ClinVar VCV record retrieval for variant reporting","prompt":"Retrieve the ClinVar record for VCV000012375 — I need the classification, associated genes, protein change, and the review status with star count."}],"resultDescription":"Returns a JSON object with a 'found' boolean; if found, includes a 'primary' record (best-reviewed) and a 'records' array. Each record contains clinical significance (pathogenic/benign/uncertain/conflicting), review status with 0–4 star rating, associated disease conditions, gene symbols, molecular consequence, protein change, and last evaluated date.","failureModes":["Variant ID not found in ClinVar — returns found: false with empty records","Malformed rsID, VCV, or HGVS notation causes a 400 or empty result","Variant exists in ClinVar but has no reviewed submissions — returns uncertain or no-assertion record","ClinVar data may be outdated relative to latest NCBI releases — last evaluated date indicates data freshness","Rare or novel variants may have no ClinVar entry at all"],"whenToPreferThis":"Choose this endpoint when you need structured, parsed ClinVar clinical significance data for a specific genetic variant without setting up your own NCBI API integration. Ideal for bioinformatics pipelines, genetic reporting tools, or research agents that need fast, per-variant lookups with star-rated review status. Prefer this over raw ClinVar API access when you want a clean JSON response with the best-reviewed record surfaced first.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-10-01T12:53:37.415Z","isFirstParty":false,"canonicalSlug":"saylor-innovations-bioinformatics-genetic-variant-clinical-5f629881"}