{"uid":"cap_q_UdyW92CtosiOVKVvvbd","slug":"ai-agents-archive-crispr-guide-shortlist-aaa-2475-33701b49","name":"AI Agents Archive — CRISPR Guide Shortlist (AAA-2475)","description":"CRISPR guide shortlist: sequence-clean guides that still hit off-target","url":"https://aiagentsarchive.com/api/handoffs/AAA-2475/body","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"pathParams":{"type":"object","properties":{"id":{"type":"string","description":"Handoff id, e.g. AAA-2432"}},"additionalProperties":{"type":"string"}},"queryParams":{"type":"object","additionalProperties":{"type":"string"}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":{"type":"json","example":{"id":"AAA-2475","body":"sealed markdown","hash":"ac3e3009db0296df5413de6cf3c353219c77a581260d1c10d6a27a79da2fb5f7","title":"CRISPR guide shortlist: sequence-clean guides that still hit off-target","access":"permanent"}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.001","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.001/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.001","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.001","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_1uNA9XdnfKxjruzOZvcoL","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.001","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Retrieves a sealed markdown document containing a curated shortlist of CRISPR guide RNAs that pass sequence-cleanliness filters but still exhibit off-target activity.","exampleAgentPrompt":"Pull up the CRISPR guide shortlist from AI Agents Archive — specifically the one listing sequence-clean guides that still hit off-target (handoff AAA-2475).","exampleUseCases":[{"title":"CRISPR off-target guide review","prompt":"Fetch the archived CRISPR guide shortlist (AAA-2475) from AI Agents Archive — I need the list of guides that look clean on sequence but still show off-target hits so I can cross-reference with my own screening data."},{"title":"Reuse prior bioinformatics research","prompt":"Instead of re-running our CRISPR off-target analysis from scratch, can you unlock the pre-done guide shortlist in AI Agents Archive with ID AAA-2475 and give me the content?"},{"title":"Validate guide RNA selection for gene editing","prompt":"I'm designing a CRISPR experiment and want to make sure I'm not accidentally using guides that have off-target issues — can you pull the sealed shortlist from AI Agents Archive (AAA-2475) that flags sequence-clean guides which still hit off-target?"}],"resultDescription":"Returns a JSON object containing: the handoff ID (AAA-2475), the full sealed markdown body of the CRISPR guide shortlist, a SHA-256 content hash for verification, the document title, and an access type (permanent). The markdown body contains the curated list of CRISPR guide RNAs that passed sequence-cleanliness checks but were found to still exhibit off-target activity.","failureModes":["Handoff ID not found — returns 404 if AAA-2475 does not exist or has been removed","Payment not received — x402 payment required before content is unlocked; missing or invalid payment returns 402","Content hash mismatch — if the client detects the returned hash does not match expected value, document integrity may be compromised","Rate limiting — repeated calls without valid payment may be throttled","Malformed request — incorrect HTTP method or missing required input fields returns 400"],"whenToPreferThis":"Use this endpoint when you need to access the specific pre-computed CRISPR guide shortlist (AAA-2475) without repeating the underlying bioinformatics work. Prefer it over running your own off-target analysis when the research is already archived and you want to save compute time and cost. It is especially useful when an agent needs to verify which sequence-clean CRISPR guides still carry off-target risk, and wants a permanent, hash-verified reference document for audit or reproducibility purposes.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T12:34:41.761Z","isFirstParty":false}