{"uid":"cap_pbrCZhmSjfp9xmIvwQ0na","slug":"extermann-2012-crash-chemotherapy-toxicity-score-fba1eb5d","name":"Extermann 2012 CRASH Chemotherapy Toxicity Score","description":"Extermann 2012 CRASH chemotherapy toxicity score (not trauma CRASH): diastolic BP, IADL, LDH versus ULN, caller-assigned MAX2 Chemotox, ECOG, Mini-Mental Status, Mini-Nutritional Assessment. Hematologic 0–6, nonhematologic 0–8, combined 0–12 counting Chemotox once. Four-level low/medium_low/medium_high/high bands with derivation incidences. Not a chemotherapy order and not CARG-TT. magent does not look up regimens.","url":"https://api.magentlab.com/api/calc/crash","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["diastolic_mm_hg","iadl","ldh_u_l","ldh_uln_u_l","chemotox","ecog","mms","mna"],"properties":{"mms":{"type":"integer","description":"Mini-Mental Status integer 0-30. Extermann 2012: 30 → 0, <30 → 2 nonhematologic points. magent does not administer the Mini-Mental Status."},"mna":{"type":"integer","description":"Mini-Nutritional Assessment integer 0-30. Extermann 2012: 28-30 → 0, <28 → 2 nonhematologic points. magent does not administer the Mini-Nutritional Assessment."},"ecog":{"type":"integer","description":"ECOG performance status integer 0-4. Extermann 2012: 0 → 0, 1-2 → 1, 3-4 → 2 nonhematologic points. magent does not assign performance status."},"iadl":{"type":"integer","description":"Instrumental activities of daily living integer 10-29 (Extermann 2012 CRASH IADL). 26-29 → 0, 10-25 → 1 hematologic point. magent does not interview the patient."},"ldh_u_l":{"type":"number","description":"Lactate dehydrogenase in U/L (1-20000). +2 hematologic points if ldh_u_l > 0.74 × ldh_uln_u_l, else 0 (empty 1-point column). magent does not assay LDH."},"chemotox":{"type":"number","description":"Caller-assigned MAX2 Chemotox from 0 to 1. 0-0.44 → 0, 0.45-0.57 → 1, >0.57 → 2. Counted once in the combined score. magent does not look up regimens."},"ldh_uln_u_l":{"type":"number","description":"Laboratory LDH upper limit of normal in U/L (50-2000). Used only as 0.74 × ULN for the LDH rule. No special-case ULN value. magent does not assay LDH."},"diastolic_mm_hg":{"type":"number","description":"Diastolic blood pressure in mm Hg (20-160). Extermann 2012 Table 4: ≤72 → 0, >72 → 1 hematologic point. magent does not measure blood pressure."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_bzExeLQ__gAUiF9Jo4Umg","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the Extermann 2012 CRASH chemotherapy toxicity score (hematologic 0–6, nonhematologic 0–8, combined 0–12) and returns a four-level toxicity risk band (low/medium_low/medium_high/high) with derivation incidences.","exampleAgentPrompt":"Calculate the Extermann 2012 CRASH chemotherapy toxicity score for my patient: diastolic BP 80 mmHg, IADL 22, LDH 310 U/L, LDH upper limit of normal 245 U/L, MAX2 Chemotox 0.52, ECOG 1, Mini-Mental Status 27, and Mini-Nutritional Assessment 24.","exampleUseCases":[{"title":"Pre-treatment geriatric oncology risk stratification","prompt":"Before we start this elderly patient on chemotherapy, calculate their CRASH toxicity score: diastolic BP 75 mmHg, IADL 20, LDH 400 U/L with a ULN of 280 U/L, MAX2 Chemotox 0.60, ECOG 2, Mini-Mental Status 25, Mini-Nutritional Assessment 22 — what risk band do they fall into?"},{"title":"Comparing hematologic vs nonhematologic subscores","prompt":"My patient has diastolic BP 65 mmHg, IADL 28, LDH 180 U/L, LDH ULN 240 U/L, MAX2 Chemotox 0.30, ECOG 0, MMS 30, MNA 29 — give me both the hematologic and nonhematologic CRASH subscores separately along with the combined score."},{"title":"Documenting CRASH score in oncology workflow","prompt":"I need the Extermann CRASH score for documentation: patient has diastolic 90 mmHg, IADL 15, LDH 500 U/L, ULN 200 U/L, caller-assigned MAX2 Chemotox 0.58, ECOG 3, Mini-Mental Status 22, Mini-Nutritional Assessment 20 — what is the combined score and four-level risk band?"}],"resultDescription":"Returns hematologic sub-score (0–6), nonhematologic sub-score (0–8), and combined CRASH score (0–12, counting Chemotox once), along with the four-level risk band (low, medium_low, medium_high, high) and the derivation-cohort toxicity incidence rates associated with each band.","failureModes":["Missing any of the eight required query parameters returns a validation error","IADL value outside 10–29 range causes a schema rejection","LDH ULN value outside 50–2000 or LDH outside 1–20000 causes a range error","Chemotox value outside 0–1 rejected","ECOG value outside 0–4 rejected","MMS or MNA outside 0–30 rejected","Diastolic BP outside 20–160 mmHg rejected","Payment failure or missing x402 header returns 402 Payment Required"],"whenToPreferThis":"Use this endpoint when you need to compute the Extermann 2012 CRASH chemotherapy toxicity score specifically — not CARG-TT or other geriatric oncology tools. Prefer it when all eight input variables (diastolic BP, IADL, LDH, LDH ULN, MAX2 Chemotox, ECOG, MMS, MNA) are already known from the clinical record and you need a structured four-level risk band with sub-scores. Note: this endpoint does not look up MAX2 Chemotox for a regimen, does not administer the MMS, MNA, or IADL instruments, and is not a chemotherapy ordering tool.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-15T01:21:31.920Z","isFirstParty":false}