{"uid":"cap_oeVXlAJgkz2kZr-fuTZ6t","slug":"sitecheck-health-travel-uniprot-protein-knowledge-bffe1f75","name":"SiteCheck Health & Travel – UniProt Protein Knowledge","description":"UniProt reviewed (Swiss-Prot) human protein entries for a gene symbol: accession, protein name, gene, sequence length and the curated function summary. Human only (taxon 9606). Up to 5 entries per call.","url":"https://api.healthtravel-api.workers.dev/api/health/uniprot-protein-knowledge?utm_source=zero.xyz","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET"],"type":"string"},"queryParams":{"type":"object","required":["gene"],"properties":{"max":{"type":"string","description":"How many entries, 1 to 5 (default 1)"},"gene":{"type":"string","description":"Human gene symbol, letters, digits and hyphens, 2 to 20 characters"}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":{"type":"json","example":{"gene":"TP53","source":"https://www.uniprot.org/ (CC BY 4.0)","entries":[{"url":"https://www.uniprot.org/uniprotkb/P04637","gene":"TP53","length":393,"function":"Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:209594…","organism":"Homo sapiens","accession":"P04637","proteinName":"Cellular tumor antigen p53"}],"checkedAt":"2026-10-23T09:36:29.124Z"}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.002","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.002/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.002","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.002","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_0uyG9qVyn3DFhjwPaqDr1","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.002","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Looks up protein function, organism, and accession data for a human gene symbol from the UniProt knowledgebase","exampleAgentPrompt":"Can you look up the UniProt protein knowledge entry for the TP53 gene — I want to know its protein name, function summary, and accession number?","exampleUseCases":[{"title":"Cancer gene protein lookup","prompt":"What protein does the BRCA2 gene encode, and what is its biological function according to UniProt? Give me the accession number too."},{"title":"Drug target research","prompt":"I'm researching EGFR as a drug target — can you pull the UniProt protein entry for the EGFR gene and tell me what it does and how long the protein is?"},{"title":"Multi-entry gene annotation","prompt":"Fetch up to 3 UniProt protein entries for the KRAS gene so I can see all annotated isoforms and their functions."}],"resultDescription":"Returns a JSON object containing the queried gene symbol, the UniProt source URL, and an array of entries. Each entry includes the UniProt URL, gene symbol, amino acid sequence length, a function description (with PubMed citations), organism (e.g. Homo sapiens), UniProt accession ID, and protein name. Also includes a checkedAt timestamp.","failureModes":["Gene symbol not found in UniProt — returns empty entries array","Invalid gene symbol format (too short, too long, or illegal characters) — returns validation error","max parameter out of range (must be 1–5) — returns error","UniProt upstream service unavailable — returns 5xx or timeout","Payment failure — call is not charged and returns 402"],"whenToPreferThis":"Choose this endpoint when you need structured protein annotation data (function, accession, organism, length) for a specific human gene symbol, sourced directly from UniProt's authoritative knowledgebase, without needing a signup or API key. Prefer it over raw UniProt API calls when you want a pay-per-use, zero-setup integration with normalized JSON output. Not suitable for non-human organisms or bulk proteome queries.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-10-29T12:39:36.206Z","isFirstParty":false,"canonicalSlug":"sitecheck-health-travel-uniprot-protein-knowledge-bffe1f75"}