{"uid":"cap_odsdZokOX6GTDeIXbKCqa","slug":"simplified-aih-score-calculator-hennes-2008-bc593e03","name":"Simplified AIH Score Calculator (Hennes 2008)","description":"Hennes 2008 simplified AIH (Table 2): caller-assigned autoantibody points 0-2 (max 2 across ANA/SMA/LKM/SLA), IgG points 0-2 (≤ULN / >ULN / >1.10×ULN), histology none 0 / compatible 1 / typical 2, viral hepatitis absent true 2. Max 8. Score <6 not_aih, 6 probable, ≥7 definite. Not a diagnosis and not the original 1999 IAHG score. magent does not titer autoantibodies, assay IgG vs ULN, or read liver histology.","url":"https://api.magentlab.com/api/calc/simplified_aih","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["autoantibody_points","igg_points","histology","viral_hepatitis_absent"],"properties":{"histology":{"enum":["none","compatible","typical"],"type":"string","description":"Caller-assigned Hennes 2008 Table 2 liver histology. none scores 0 (hepatitis is required for histology points). compatible scores 1. typical scores 2. magent does not read liver histology."},"igg_points":{"enum":[0,1,2],"type":"integer","description":"Caller-assigned Hennes 2008 Table 2 IgG points (0, 1, or 2). 0: IgG ≤ULN. 1: IgG >ULN. 2: IgG >1.10×ULN. magent does not assay IgG vs ULN."},"autoantibody_points":{"enum":[0,1,2],"type":"integer","description":"Caller-assigned Hennes 2008 Table 2 autoantibody points (0, 1, or 2; max 2 across ANA/SMA/LKM/SLA). 0: not scoring. 1: ANA or SMA ≥1:40. 2: ANA or SMA ≥1:80 or LKM ≥1:40 or SLA positive. magent does not titer autoantibodies."},"viral_hepatitis_absent":{"type":"boolean","description":"Caller-assigned Hennes 2008 Table 2 viral hepatitis absence. true scores 2; false scores 0. magent does not interpret viral serology."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":{"type":"json","example":{"path":"/api/calc/simplified_aih","count":2,"items":[{"score":8,"formula":"simplified_aih","aih_band":"definite","citation":{"id":"hennes-2008","doi":"10.1002/hep.22322","pmid":"18537184","title":"Simplified criteria for the diagnosis of autoimmune hepatitis","source":"Hepatology. 2008;48(1):169-176","authors":"Hennes EM, Zeniya M, Czaja AJ, Parés A, Dalekos GN, Krawitt EL, Bittencourt PL, Porta G, Boberg KM, Hofer H, Francesconi F, Dufour JF, Vergani D, Lohse AW; International Autoimmune Hepatitis Group"},"max_score":8,"components":[{"value":2,"factor":"autoantibody_points","points":2,"present":true},{"value":2,"factor":"igg_points","points":2,"present":true},{"value":"typical","factor":"histology","points":2,"present":true},{"factor":"viral_hepatitis_absent","points":2,"present":true}],"disclaimer":"Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.","formula_expression":"simplified AIH = autoantibody_points (0-2) + igg_points (0-2) + histology (none 0, compatible 1, typical 2) + viral_hepatitis_absent (true 2); Hennes 2008 Table 2; max 8; <6 not_aih, 6 probable, ≥7 definite"},{"score":8,"formula":"simplified_aih","aih_band":"definite","citation":{"id":"hennes-2008","doi":"10.1002/hep.22322","pmid":"18537184","title":"Simplified criteria for the diagnosis of autoimmune hepatitis","source":"Hepatology. 2008;48(1):169-176","authors":"Hennes EM, Zeniya M, Czaja AJ, Parés A, Dalekos GN, Krawitt EL, Bittencourt PL, Porta G, Boberg KM, Hofer H, Francesconi F, Dufour JF, Vergani D, Lohse AW; International Autoimmune Hepatitis Group"},"max_score":8,"components":[{"value":2,"factor":"autoantibody_points","points":2,"present":true},{"value":2,"factor":"igg_points","points":2,"present":true},{"value":"typical","factor":"histology","points":2,"present":true},{"factor":"viral_hepatitis_absent","points":2,"present":true}],"disclaimer":"Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.","formula_expression":"simplified AIH = autoantibody_points (0-2) + igg_points (0-2) + histology (none 0, compatible 1, typical 2) + viral_hepatitis_absent (true 2); Hennes 2008 Table 2; max 8; <6 not_aih, 6 probable, ≥7 definite"}]}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_ITqwkjp4wsmTMaj56J_RK","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the Hennes 2008 simplified autoimmune hepatitis (AIH) score from caller-assigned autoantibody, IgG, histology, and viral hepatitis absence inputs, returning a total score and classification (not_aih / probable / definite).","exampleAgentPrompt":"Calculate the simplified AIH score for a patient with autoantibody points of 2 (ANA ≥1:80), IgG points of 2 (IgG >1.10× ULN), typical liver histology, and viral hepatitis confirmed absent — what's the total score and classification?","exampleUseCases":[{"title":"Hepatology clinic AIH screening","prompt":"I have a patient with ANA ≥1:80 so autoantibody points are 2, IgG is just above the upper limit of normal so IgG points are 1, liver biopsy shows compatible histology, and viral hepatitis is absent — can you run the simplified AIH score and tell me if it's probable or definite?"},{"title":"EHR automation pipeline scoring","prompt":"For this patient record: autoantibody points 1 (ANA 1:40), IgG points 0 (normal), histology none, and viral hepatitis not yet excluded — compute the Hennes 2008 simplified AIH score and classification."},{"title":"Differential diagnosis support","prompt":"Help me rule in or out autoimmune hepatitis: the patient has SLA positive so autoantibody points are 2, IgG points are 2 because IgG is more than 1.10 times ULN, histology is typical, and viral hepatitis is absent — what does the simplified AIH score say?"}],"resultDescription":"Returns the total simplified AIH score (integer 0–8) and a classification string: 'not_aih' for scores below 6, 'probable' for a score of 6, or 'definite' for scores of 7 or 8. Does not perform any laboratory interpretation itself — all four component point values must be pre-assigned by the caller.","failureModes":["Missing required query parameters (autoantibody_points, igg_points, histology, viral_hepatitis_absent) returns a validation error","Out-of-range integer values for autoantibody_points or igg_points (outside 0-2) are rejected","Invalid histology enum value (must be 'none', 'compatible', or 'typical') returns an error","Non-boolean value for viral_hepatitis_absent causes a schema validation failure","Score does not constitute a clinical diagnosis; misuse of output without physician interpretation is a user-side failure"],"whenToPreferThis":"Use this endpoint when an agent or workflow has already obtained and interpreted the four Hennes 2008 Table 2 criteria — autoantibody titer class, IgG-vs-ULN class, histology reading, and viral hepatitis serology result — and needs to convert them into a standardized total score and probable/definite/not_aih classification. Do not use if raw lab values (IgG concentration, antibody titers, histology slides, or viral serology) need to be interpreted; those steps must be done upstream. This is specifically the 2008 simplified score, not the original 1999 IAHG scoring system.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-15T01:20:31.144Z","isFirstParty":false}