{"uid":"cap_n4KJEtdaCGtqRj-ME38E-","slug":"ips-e-score-calculator-condoluci-2020-for-early-stage-cll-953612b1","name":"IPS-E Score Calculator (Condoluci 2020) for Early-Stage CLL","description":"Condoluci 2020 IPS-E for asymptomatic early-stage chronic lymphocytic leukemia: unmutated IGHV 1, ALC >15 ×10^9/L 1, palpable lymph nodes 1; max 3. Low 0, intermediate 1, high 2–3. Time-to-first-treatment score, not a treatment start order; not CLL-IPI, Rai, or Binet. magent does not assay IGHV, count lymphocytes, or palpate nodes.","url":"https://api.magentlab.com/api/calc/ips_e","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["ighv_unmutated","alc_k_ul","palpable_lymph_nodes"],"properties":{"alc_k_ul":{"type":"number","description":"Absolute lymphocyte count in ×10^9/L (0.1-500). >15 scores 1 (Condoluci 2020 IPS-E). 15.0 is the ≤15 arm and scores 0. magent does not count lymphocytes."},"ighv_unmutated":{"type":"boolean","description":"Unmutated IGHV as assigned by the caller (Condoluci 2020 IPS-E). true scores 1. magent does not sequence IGHV."},"palpable_lymph_nodes":{"type":"boolean","description":"Palpable lymph nodes as assigned by the caller (Condoluci 2020 IPS-E). true scores 1. magent does not palpate lymph nodes."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_g2hm_eSz9u_0n8Mf2je3X","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the Condoluci 2020 IPS-E time-to-first-treatment prognostic score (0–3) for asymptomatic early-stage chronic lymphocytic leukemia using three caller-assigned binary/numeric inputs.","exampleAgentPrompt":"Calculate the IPS-E score for an early-stage CLL patient who has unmutated IGHV, an absolute lymphocyte count of 20 ×10^9/L, and palpable lymph nodes — tell me their risk group.","exampleUseCases":[{"title":"Risk-stratify newly diagnosed CLL patient","prompt":"I have a patient just diagnosed with asymptomatic early-stage CLL. Their IGHV is unmutated, ALC is 22 ×10^9/L, and they have no palpable lymph nodes. What is their IPS-E score and risk category?"},{"title":"Estimate time-to-treatment for low-risk CLL","prompt":"My CLL patient has mutated IGHV, an ALC of 12 ×10^9/L, and no palpable lymph nodes. Run the Condoluci IPS-E score so I can tell them how urgent treatment might be."},{"title":"High-risk CLL prognostic counseling","prompt":"Can you compute the IPS-E score for a patient with unmutated IGHV, ALC of 30 ×10^9/L, and palpable lymph nodes — I need the score and whether this puts them in the high-risk group."}],"resultDescription":"Returns an IPS-E integer score from 0 to 3, where 0 = low risk, 1 = intermediate risk, and 2–3 = high risk for time to first treatment in asymptomatic early-stage CLL, based on the three Condoluci 2020 criteria.","failureModes":["Missing required query parameters (ighv_unmutated, alc_k_ul, palpable_lymph_nodes) returns a 400 error","ALC value outside the accepted range (0.1–500 ×10^9/L) may return validation error","Payment not provided or invalid x402 payment header causes 402 response","Caller misclassifying clinical inputs (IGHV status, ALC, node exam) before submission — the API trusts caller-assigned values without verification"],"whenToPreferThis":"Use this endpoint when you need a fast, standardized Condoluci 2020 IPS-E score for asymptomatic early-stage CLL and already have the three required clinical values (IGHV mutation status, ALC, palpable lymph nodes) pre-assessed. This is specifically for prognostic time-to-first-treatment stratification in early CLL, not for CLL-IPI, Rai staging, or Binet staging. Prefer this over a general LLM computation when you need a reproducible, published-algorithm result.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T19:07:42.580Z","isFirstParty":false}