{"uid":"cap_kuQKvuMtsGbRpHJadq_UX","slug":"gene-expression-lookup-by-tissue-gtex-7438fae6","name":"Gene Expression Lookup by Tissue (GTEx)","description":"Look up median expression of a human gene across normal tissues, highest expression first.","url":"https://win.oneshotagent.com/v1/tools/lookup/gene-expression?utm_source=zero.xyz","method":"POST","headers":{},"bodySchema":{"type":"object","properties":{"gene":{"type":"string","description":"Official human gene symbol (TP53) or Ensembl gene ID (ENSG00000141510), with or without a version. 1 to 30 characters. Letters, digits, \".\", \"_\" and \"-\" only."},"limit":{"type":"integer","description":"Tissues returned, highest median first; omit for all tissues. From 1 to 60."}}},"responseSchema":{"type":"json","example":{"gene":{"symbol":"TP53","chromosome":"chr17","ensembl_id":"ENSG00000141510","gencode_id":"ENSG00000141510.19","description":"tumor protein p53","entrez_gene_id":7157},"unit":"TPM","dataset":"gtex_v11","matched":true,"tissues":[{"tissue":"Cells_EBV-transformed_lymphocytes","median_tpm":54.4686,"ontology_id":"EFO:0000572"},{"tissue":"Skin_Sun_Exposed_Lower_leg","median_tpm":25.8191,"ontology_id":"UBERON:8480050"}]}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.01","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.01/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.01","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.01","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_uoS7O4FIMsqckXshXTadm","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.01","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Returns median TPM expression of a human gene across normal tissues, ranked highest to lowest, using GTEx v11 data.","exampleAgentPrompt":"What are the top 5 tissues where TP53 is most expressed in normal human tissue? Use the GTEx dataset and show me the median TPM values.","exampleUseCases":[{"title":"Identify primary expression site for drug target","prompt":"I'm researching ACE2 as a drug target — which 10 tissues show the highest median expression of ACE2 in normal humans? Give me the TPM values."},{"title":"Verify housekeeping gene expression","prompt":"Can you pull GTEx expression data for GAPDH across all tissues? I want to confirm it's broadly and evenly expressed as a housekeeping gene."},{"title":"Profile cancer gene in normal tissue","prompt":"Look up the tissue expression profile for KRAS using its Ensembl ID ENSG00000133703 — show me the top 15 tissues with the highest median TPM."}],"resultDescription":"Returns a JSON object containing gene metadata (symbol, chromosome, Ensembl ID, Entrez ID, description), the unit (TPM), dataset version (gtex_v11), and an ordered array of tissues with their median TPM values and ontology IDs, sorted highest expression first.","failureModes":["Unrecognized gene symbol or Ensembl ID returns matched:false with empty tissues array","Invalid characters in gene name return a validation error","Limit out of range (>60 or <1) returns a schema validation error","Network timeout for very broad queries","Gene exists but has no GTEx data (e.g. very new genes not in v11)"],"whenToPreferThis":"Use this endpoint when you need authoritative, curated median expression data for a human gene across normal (non-diseased) tissues from the GTEx v11 dataset. Prefer this over RNA-seq database queries or literature lookups when you need structured, machine-readable TPM values ranked by expression level. Ideal for drug target assessment, biomarker validation, tissue specificity analysis, or any pipeline that needs normalized expression baselines.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-10-25T12:31:22.206Z","isFirstParty":false,"canonicalSlug":"gene-expression-lookup-by-tissue-gtex-7438fae6"}