{"uid":"cap_kuCyF39y1fHIF9pnxnwPo","slug":"magent-psa-doubling-time-calculator-pound-1999-a1575f8b","name":"magent PSA Doubling Time Calculator (Pound 1999)","description":"Pound 1999 PSA doubling time from two rising PSA values: psadt_months = ln(2) x interval_months / ln(psa2_ng_ml / psa1_ng_ml), 1 decimal. PSA each 0.2-10000 ng/mL; psa2 must exceed psa1; interval_months 0.25-120. Reports the Pound split <=10 vs >10 months (exactly 10.0 is <=10). Two-point first-order kinetics only. magent does not measure PSA. Not a medical device.","url":"https://api.magentlab.com/api/calc/psadt","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["psa1_ng_ml","psa2_ng_ml","interval_months"],"properties":{"psa1_ng_ml":{"type":"number","description":"Earlier serum PSA in ng/mL (0.2-10000). Pound biochemical recurrence used detectable PSA ≥0.2 ng/mL. magent does not measure PSA."},"psa2_ng_ml":{"type":"number","description":"Later serum PSA in ng/mL (0.2-10000). Must be greater than psa1_ng_ml (rising). magent does not measure PSA."},"interval_months":{"type":"number","description":"Months between the two PSA values (0.25-120, magent clamp). Pound 1999 does not publish an input band for this two-point tool."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_sDDJhQN6UczhyE_N50GUr","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Calculates PSA doubling time (PSADT) in months using the Pound 1999 two-point first-order kinetic formula from two rising PSA values and the interval between them.","exampleAgentPrompt":"My patient had a PSA of 0.5 ng/mL six months ago and now it's 1.2 ng/mL — can you calculate the PSA doubling time using the Pound 1999 formula and tell me whether it falls in the <=10 or >10 month category?","exampleUseCases":[{"title":"Post-prostatectomy biochemical recurrence monitoring","prompt":"My prostate cancer patient had a PSA of 0.3 ng/mL nine months ago and it's now 0.8 ng/mL — calculate the PSADT using the Pound 1999 two-point method and tell me if it's <=10 or >10 months."},{"title":"Radiation therapy follow-up PSA kinetics","prompt":"A patient finishing radiation had PSA of 1.4 ng/mL 12 months ago and now it's 3.1 ng/mL. What's the PSA doubling time using Pound 1999, and does it fall under or over 10 months?"},{"title":"Active surveillance decision support","prompt":"For an active surveillance patient with PSA rising from 4.2 to 6.7 ng/mL over 18 months, compute the PSADT using Pound 1999 and classify it as short or long doubling time."}],"resultDescription":"Returns the PSA doubling time in months rounded to 1 decimal place, calculated via ln(2) × interval_months / ln(psa2/psa1), along with a Pound 1999 risk classification indicating whether PSADT is <=10 months (shorter, more aggressive) or >10 months (longer, less aggressive). Exactly 10.0 months is classified as <=10.","failureModes":["psa2 not greater than psa1 — PSA must be rising for this formula to apply; returns error","psa1 or psa2 outside 0.2–10000 ng/mL range — returns validation error","interval_months outside 0.25–120 range — returns validation error or clamped result","missing required query parameters — returns 400 or schema error","division by zero if psa values are equal — psa2 must strictly exceed psa1"],"whenToPreferThis":"Use this endpoint when you need a fast, reproducible Pound 1999 two-point PSADT calculation from exactly two serial PSA measurements and a known interval. Ideal for clinical decision support workflows, EMR integrations, or agentic oncology tools that need PSADT with the standard <=10/> 10 month Pound classification. Not suitable if you need multi-point regression-based PSADT, PSA velocity in ng/mL/year, or if you need to actually measure or retrieve PSA values from a lab system.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T07:15:24.003Z","isFirstParty":false}