{"uid":"cap_jTQ4m1Fxu4akytH3yaCfB","slug":"duke-iscvid-2023-fowler-infective-endocarditis-criteria-calculator-3939b38b","name":"Duke-ISCVID 2023 (Fowler) Infective Endocarditis Criteria Calculator","description":"2023 Duke-ISCVID (Fowler) IE criteria. Definite if pathologic_definite or clinical_definite (2 major, or 1 major plus 3 minor, or 5 minor). Possible if 1 major plus 1 minor or 3 minor. Rejected if neither, or if a rejected flag is true and definite does not hold. Majors are caller-assigned microbiologic, imaging, and surgical domains. minor_microbiologic is not counted when major_microbiologic is true. magent does not read echo, PET, or cultures. Not Durack 1994. Not Li 2000. Not a diagnosis.","url":"https://api.magentlab.com/api/calc/duke_iscvid","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["pathologic_definite","major_microbiologic","major_imaging","major_surgical","minor_predisposition","minor_fever","minor_vascular","minor_immunologic","minor_microbiologic","rejected_firm_alternate_diagnosis","rejected_resolved_le_4_days_antibiotics","rejected_no_pathology_le_4_days_antibiotics"],"properties":{"minor_fever":{"type":"boolean","description":"Fever ≥38.0 C (Fowler 2023 minor). true or false as assigned by the caller. magent does not measure temperature."},"major_imaging":{"type":"boolean","description":"Fowler 2023 imaging major as assigned by the caller (echocardiogram, cardiac CT, or 18F-FDG PET/CT meeting the 2023 imaging major). true or false. magent does not read imaging."},"major_surgical":{"type":"boolean","description":"Fowler 2023 surgical major as assigned by the caller (intraoperative inspection or subsequent histology or microbiology documenting IE). true or false. New 2023 major domain. magent does not examine the operative field."},"minor_vascular":{"type":"boolean","description":"Vascular phenomena (Fowler 2023 minor) as assigned by the caller. true or false. magent does not examine the patient."},"minor_immunologic":{"type":"boolean","description":"Immunologic phenomena (Fowler 2023 minor) as assigned by the caller. true or false. magent does not examine the patient."},"major_microbiologic":{"type":"boolean","description":"Fowler 2023 microbiologic major as assigned by the caller (typical organisms from two or more sets, or another published microbiologic major including Coxiella or Bartonella serology). true or false. magent does not interpret cultures."},"minor_microbiologic":{"type":"boolean","description":"Microbiologic evidence not meeting the microbiologic major (Fowler 2023 minor). true or false as assigned by the caller. Not counted in minor_count when major_microbiologic is true. magent does not interpret cultures."},"pathologic_definite":{"type":"boolean","description":"Microorganisms or histopathology of active IE in a vegetation, embolus, or intracardiac abscess, including 2023 molecular or tissue methods, as assigned by the caller (Fowler 2023 pathologic definite). true or false. magent does not examine tissue."},"minor_predisposition":{"type":"boolean","description":"Predisposing heart condition or intravenous drug use (Fowler 2023 minor). true or false as assigned by the caller. magent does not take a history."},"rejected_firm_alternate_diagnosis":{"type":"boolean","description":"Firm alternate diagnosis explaining evidence of IE (Fowler 2023 rejected). true or false as assigned by the caller. Classification is rejected only when definite does not hold."},"rejected_resolved_le_4_days_antibiotics":{"type":"boolean","description":"Manifestations of IE resolved with antibiotic therapy for 4 days or less (Fowler 2023 rejected). true or false as assigned by the caller."},"rejected_no_pathology_le_4_days_antibiotics":{"type":"boolean","description":"No pathologic evidence of IE at surgery or autopsy after antibiotic therapy for 4 days or less (Fowler 2023 rejected). true or false as assigned by the caller. magent does not examine tissue."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_PpUhbX9C5rn1VK_fEVy3H","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Applies the 2023 Duke-ISCVID (Fowler) modified criteria to caller-supplied boolean flags and returns a classification of Definite, Possible, or Rejected infective endocarditis.","exampleAgentPrompt":"Apply the 2023 Duke-ISCVID (Fowler) infective endocarditis criteria for a patient where major_microbiologic is true, major_imaging is false, major_surgical is false, minor_fever is true, minor_predisposition is true, minor_vascular is false, minor_immunologic is false, minor_microbiologic is false, pathologic_definite is false, and none of the rejection flags are true — is this patient Definite, Possible, or Rejected for IE?","exampleUseCases":[{"title":"Bacteremia workup IE classification","prompt":"I have a patient with positive blood cultures for S. aureus (major_microbiologic true), an echocardiogram that meets imaging major (major_imaging true), no surgical findings (major_surgical false), fever over 38C (minor_fever true), no vascular or immunologic phenomena, no minor microbiologic, no predisposition, pathologic_definite false, and no rejection flags — can you classify this as Definite, Possible, or Rejected IE using the 2023 Fowler Duke-ISCVID criteria?"},{"title":"Possible IE after short antibiotic course","prompt":"Patient had one positive blood culture (major_microbiologic false), no imaging major, no surgical major, pathologic_definite false, minor_fever true, minor_predisposition true, minor_vascular false, minor_immunologic false, minor_microbiologic true, and the rejected_resolved_le_4_days_antibiotics flag is true — run the 2023 Duke-ISCVID criteria and tell me if this is Definite, Possible, or Rejected."},{"title":"Rejected IE with firm alternate diagnosis","prompt":"This patient has no major criteria met (major_microbiologic false, major_imaging false, major_surgical false, pathologic_definite false), only one minor (minor_fever true, all others false), and there is a firm alternate diagnosis confirmed (rejected_firm_alternate_diagnosis true) — apply Fowler 2023 Duke-ISCVID IE criteria and confirm if this should be classified as Rejected."}],"resultDescription":"Returns a structured result with the IE classification (Definite, Possible, or Rejected), the specific rule that was matched (e.g. '2 major', '1 major + 3 minor', '5 minor', '1 major + 1 minor', '3 minor'), counts of qualifying major and minor criteria, and notes on any suppression applied (e.g. minor_microbiologic not counted when major_microbiologic is true). Not a clinical diagnosis.","failureModes":["Missing required boolean query parameters returns a validation error","Ambiguous or non-boolean values for flags cause rejection","If pathologic_definite is true but conflicting flags are set, the endpoint still resolves to Definite","Edge case: minor_microbiologic silently excluded from count when major_microbiologic is true — callers must be aware of this suppression rule","Network or payment failure (x402) prevents call completion"],"whenToPreferThis":"Use this endpoint when you need a deterministic, published-criteria-based classification of infective endocarditis per the 2023 Duke-ISCVID (Fowler) update — specifically when your system has already assigned major and minor criteria flags and you need the combinatorial rule applied correctly. Prefer this over implementing the criteria yourself to avoid logic errors in the multi-flag suppression rules and rejection conditions. Do NOT use for the older Durack 1994 or Li 2000 criteria, and do NOT use if you expect the endpoint to read echocardiograms, cultures, PET scans, or operative reports — all inputs must be pre-assigned by the caller.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-15T06:52:55.250Z","isFirstParty":false}