{"uid":"cap_huFQgOAnQw0oHxjD63G6I","slug":"string-protein-protein-interaction-network-lookup-c8c76a4c","name":"STRING Protein-Protein Interaction Network Lookup","description":"STRING protein-protein interaction partners for a human gene (STRING API, CC BY 4.0): partner gene name, combined confidence score (0-1) and evidence scores for experiments, databases and text mining. Up to 20 partners. No enrichment analysis.","url":"https://api.healthtravel-api.workers.dev/api/health/string-protein-networks?utm_source=zero.xyz","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET"],"type":"string"},"queryParams":{"type":"object","required":["gene"],"properties":{"max":{"type":"string","description":"How many partners, 1 to 20 (default 10)"},"gene":{"type":"string","description":"Human gene symbol, letters, digits and hyphens, 2 to 20 characters"}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":{"type":"json","example":{"gene":"TP53","source":"https://string-db.org/ (CC BY 4.0)","species":"Homo sapiens (9606)","partners":[{"gene":"SIRT1","score":0.999,"evidence":{"databases":0.9,"textMining":0.886,"experiments":0.999,"coexpression":0}},{"gene":"MAPK1","score":0.999,"evidence":{"databases":0.9,"textMining":0.68,"experiments":0.999,"coexpression":0.052}}],"checkedAt":"2026-10-23T09:36:31.322Z"}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.002","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.002/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.002","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.002","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_TgB9nDJazjk0zu6ShU0Wc","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.002","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Returns up to 20 protein-protein interaction partners for a human gene from the STRING database, including combined confidence scores and evidence breakdowns.","exampleAgentPrompt":"Can you look up the top 15 protein interaction partners for TP53 from STRING, including their confidence scores and evidence types like experiments and text mining?","exampleUseCases":[{"title":"Cancer gene interaction network research","prompt":"What are the top 10 protein-protein interaction partners for KRAS in the STRING database? I need the combined confidence scores and experimental evidence scores for each partner."},{"title":"Drug target pathway exploration","prompt":"Look up the STRING interaction partners for EGFR — I want up to 20 partners with their database, text mining, and coexpression evidence scores to understand which pathways it's involved in."},{"title":"Tumor suppressor protein network mapping","prompt":"Can you get me the protein interaction network for BRCA1 from STRING? Give me the top 20 partners and include all the evidence scores so I can see which interactions are experimentally validated."}],"resultDescription":"Returns a JSON object with the queried gene symbol, source attribution (STRING CC BY 4.0), species (Homo sapiens 9606), timestamp, and an array of up to 20 partner objects each containing the partner gene symbol, a combined confidence score (0–1), and an evidence breakdown with sub-scores for experiments, databases, text mining, and coexpression.","failureModes":["Invalid or unrecognized gene symbol returns empty partner list or error","Gene symbol outside 2–20 character alphanumeric/hyphen constraint rejected","max parameter outside 1–20 range may be clamped or rejected","STRING API upstream unavailability causes service error","Non-human gene symbols may return no results since only Homo sapiens (9606) is supported"],"whenToPreferThis":"Choose this endpoint when you need fast, structured access to STRING protein-protein interaction data for a specific human gene, including confidence scores and multi-evidence breakdowns, without needing full enrichment analysis or pathway annotations. Prefer this over direct STRING API calls when operating in an x402 micropayment environment or when you need a simplified JSON response limited to top partners.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-10-29T00:34:20.536Z","isFirstParty":false,"canonicalSlug":"string-protein-protein-interaction-network-lookup-c8c76a4c"}