{"uid":"cap_hsqU8RkgOb4M46pGe45KG","slug":"longevitypulse-dna-variant-interpreter-e840847d","name":"LongevityPulse DNA Variant Interpreter","description":"DNA variant interpretation for longevity agents. Reads consumer-test genes/rsIDs (23andMe, AncestryDNA) e.g. APOE-e4, MTHFR-C677T, FOXO3. Honest effect sizes (not fear), actionability tiers, myth-flags overstated claims like MTHFR panic, and says plainly when a variant lacks real evidence. Not medical advice.","url":"https://longevitypulse.theaslangroupllc.com/api/longevity/dna","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"queryParams":{"type":"object","properties":{"lang":{"type":"string","description":"en|es|fr|de|ja|zh|ko|pt|ar|hi (default en)"},"variants":{"type":"string","description":"Comma-separated gene/variant IDs or rsIDs from a consumer DNA test, e.g. APOE-e4,MTHFR-C677T,FOXO3 (up to 8, required)"}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"errors":{"type":"object","description":"Documented error responses, keyed by HTTP status code","additionalProperties":{"type":"object","required":["description"],"properties":{"example":{"type":"object"},"description":{"type":"string"}}}},"example":{"type":"object"}}}}},"responseSchema":{"type":"json","example":{"results":[{"gene":"APOE","input":"APOE-e4","recognized":true,"effect_size":"One ε4 copy: ~2-3x Alzheimer's odds ratio vs ε3/ε3; two copies: ~8-12x — one of the largest common-variant effect sizes in human genetics, still a probabilistic shift, not a diagnosis","actionability_tier":"well-replicated","resolved_identifier":"rs429358 (APOE ε4 tagging SNP)"},{"input":"MTHFR-C677T","myth_flag":{"the_myth":"Marketed as a serious \"detox\"/methylation defect requiring supplement protocols","is_commonly_overstated_or_mythologized":true}}],"variants_requested":["APOE-e4","MTHFR-C677T","FOXO3"]}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.2","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.2/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.2","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.2","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_oCAryMtcOjATSLRGHg9U7","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.2","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Interprets consumer DNA test variants (rsIDs/genes from 23andMe, AncestryDNA) for longevity relevance, providing honest effect sizes, actionability tiers, and myth-busting flags","exampleAgentPrompt":"I just got my 23andMe results back — can you interpret what my APOE-e4 variant and MTHFR C677T actually mean for my longevity, with honest effect sizes and whether the MTHFR hype is overblown?","exampleUseCases":[{"title":"Evaluate genetic risk for cognitive aging","prompt":"I have the APOE-e4 variant from my AncestryDNA test — how much should I actually worry about this for my brain health as I age, and what can I realistically do about it?"},{"title":"Debunk health supplement hype claims","prompt":"A lot of wellness brands claim I need special supplements because I'm MTHFR C677T positive — is that panic justified by actual science, or am I being sold something I don't need?"},{"title":"Prioritize actionable genetic findings","prompt":"My 23andMe results show several longevity-related variants like FOXO3 and APOE — which ones are worth actually changing my behavior for, and which are just interesting but not actionable?"}],"resultDescription":"Returns a structured interpretation of the queried DNA variant including: honest effect size (not sensationalized), actionability tier indicating how much the variant should influence behavior, a myth-flag if the variant is commonly overstated in popular media, evidence quality rating, and a plain-language summary of what the variant actually means for longevity — with a clear disclaimer that this is not medical advice.","failureModes":["Unknown or unsupported rsID returns no interpretation with a notice that the variant lacks evidence","Malformed gene/rsID input returns a validation error","Variant exists in database but has insufficient longevity-specific evidence — returns low-evidence flag rather than interpretation","Rate limiting or payment failure returns 402 Payment Required","Overly broad query without a specific variant returns a prompt for a specific rsID or gene name"],"whenToPreferThis":"Choose this endpoint when an agent needs to interpret specific consumer DNA test results (23andMe, AncestryDNA) for longevity context, especially when honest calibration of effect sizes and myth-busting of overhyped variants like MTHFR is important. Prefer this over generic medical databases when the user has actual rsID or gene-name inputs from a consumer test and wants actionable, evidence-tiered longevity guidance rather than raw clinical data.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-15T06:36:07.306Z","isFirstParty":false}