{"uid":"cap_hf-Y5Hv3kRH3MAJRqsM9F","slug":"esc-2021-score2-cardiovascular-risk-calculator-5681ba3d","name":"ESC 2021 SCORE2 Cardiovascular Risk Calculator","description":"ESC 2021 SCORE2 10-year fatal plus non-fatal CVD percent for age 40-69 from sex, current smoking, systolic BP, non-HDL cholesterol, and European geographic risk region (low, moderate, high, very_high). Published sex-specific coefficients and region scale1/scale2. Not SCORE2-OP, not SCORE2-Diabetes, not 2013 PCE, not Reynolds, not a diagnosis or statin order. magent does not assay lipids.","url":"https://api.magentlab.com/api/calc/score2","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["age","sex","smoker","sbp_mm_hg","non_hdl_mmol_l","european_risk_region"],"properties":{"age":{"type":"integer","description":"Age in years (integer 40-69). SCORE2 2021 is for ages 40-69. Not SCORE2-OP (age 70 or older)."},"sex":{"enum":["female","male"],"type":"string","description":"Sex used by the sex-specific SCORE2 2021 coefficients (female or male)."},"smoker":{"type":"boolean","description":"Current cigarette smoking as assigned by the caller (true or false). magent does not take a smoking history."},"sbp_mm_hg":{"type":"number","description":"Systolic blood pressure in mm Hg (50-250). Enters as (SBP-120)/20. magent does not measure blood pressure."},"non_hdl_mmol_l":{"type":"number","description":"Non-HDL cholesterol in mmol/L (1-12). SCORE2 charts display non-HDL. The published equation uses TC and HDL at the paper HDL centering 1.3 mmol/L (TC = non-HDL + 1.3). The printed 50-year-old example is TC 5.5 and HDL 1.3 (non-HDL 4.2). magent does not assay lipids."},"european_risk_region":{"enum":["low","moderate","high","very_high"],"type":"string","description":"Geographic SCORE2 2021 calibration region (low, moderate, high, or very_high) as printed in that paper. Not race. Not ethnicity."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_P0k-tvIixuaxZh01LowcC","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Calculates the ESC 2021 SCORE2 10-year risk (%) of fatal and non-fatal cardiovascular events for adults aged 40–69 using sex, smoking status, systolic BP, non-HDL cholesterol, and European geographic risk region.","exampleAgentPrompt":"Using the ESC 2021 SCORE2 model, calculate the 10-year cardiovascular risk for a 57-year-old male who currently smokes, has a systolic BP of 145 mmHg, non-HDL cholesterol of 4.2 mmol/L, and lives in a high-risk European region.","exampleUseCases":[{"title":"Preventive cardiology consult risk stratification","prompt":"I need the SCORE2 2021 cardiovascular risk for a 62-year-old female non-smoker with systolic BP of 160 mmHg, non-HDL cholesterol of 3.8 mmol/L, living in a low-risk European country. What's her 10-year CVD risk?"},{"title":"Population health screening tool integration","prompt":"Run the ESC SCORE2 calculation for a 48-year-old male who smokes, has a systolic BP of 130 mmHg, non-HDL of 5.0 mmol/L, and is from a very high-risk European region. I need the 10-year fatal and non-fatal CVD risk percentage."},{"title":"Clinical decision support for GP follow-up","prompt":"What is the SCORE2 10-year cardiovascular risk for a 44-year-old female, non-smoker, systolic blood pressure 118 mmHg, non-HDL cholesterol 3.2 mmol/L, in a moderate-risk European region?"}],"resultDescription":"Returns the ESC 2021 SCORE2 10-year risk percentage for combined fatal and non-fatal cardiovascular events (heart attack and stroke), computed using published sex-specific coefficients and geographic region calibration scale factors. The result is a numeric risk estimate appropriate for clinical risk stratification of adults aged 40–69.","failureModes":["Age outside 40–69 range returns an error (SCORE2 is not SCORE2-OP for 70+)","Invalid or missing european_risk_region enum value causes a validation error","Non-HDL cholesterol outside 1–12 mmol/L range may be rejected","Systolic BP outside 50–250 mmHg range may be rejected","Missing required query parameters (age, sex, smoker, sbp_mm_hg, non_hdl_mmol_l, european_risk_region) returns a 400 error","Payment failure via x402 results in a 402 response before computation"],"whenToPreferThis":"Use this endpoint when you need the specific ESC 2021 SCORE2 model for adults aged 40–69 in a European clinical context, based on non-HDL cholesterol and the official geographic risk region calibration. Prefer this over PCE (US-focused, different coefficients), SCORE2-OP (age 70+), SCORE2-Diabetes (requires diabetes inputs), or Reynolds Risk Score (requires hsCRP/family history). Ideal when inputs are systolic BP and non-HDL cholesterol as recorded in European clinical practice.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T13:06:05.551Z","isFirstParty":false}