{"uid":"cap_gwkiqSPFYOKGiBHDnvK95","slug":"nccn-ipi-calculator-for-dlbcl-zhou-2014-6b8d5560","name":"NCCN-IPI Calculator for DLBCL (Zhou 2014)","description":"Zhou 2014 NCCN-IPI for DLBCL in the rituximab era: age (≤40 0, 41–60 1, 61–75 2, ≥76 3), LDH/ULN (≤1 0, >1–3 1, >3 2), Ann Arbor III or IV 1, major-organ extranodal (bone marrow, CNS, liver/GI tract, or lung) 1, ECOG ≥2 1; max 8. Low 0–1, low_intermediate 2–3, high_intermediate 4–5, high 6–8. Deterministic published score; not a DLBCL diagnosis or treatment choice; not Shipp IPI, not R-IPI, not CNS-IPI. magent does not assay LDH or stage lymphoma.","url":"https://api.magentlab.com/api/calc/nccn_ipi","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["age","ecog","ldh_uln_ratio","stage_iii_or_iv","extranodal_major"],"properties":{"age":{"type":"integer","description":"Age in years (18-120). ≤40 scores 0; 41–60 scores 1; 61–75 scores 2; ≥76 scores 3 (Zhou 2014 NCCN-IPI refined age). Age 40 scores 0; 41 and 60 score 1; 61 and 75 score 2; 76 scores 3. Not Shipp IPI binary >60."},"ecog":{"type":"integer","description":"ECOG performance status 0-4 as assigned by the caller (Zhou 2014 NCCN-IPI). ≥2 scores 1. magent does not assign ECOG."},"ldh_uln_ratio":{"type":"number","description":"Serum LDH divided by the laboratory ULN (0.1-20). ≤1 scores 0; >1 and ≤3 scores 1; >3 scores 2 (Zhou 2014 NCCN-IPI). 1.0 scores 0; 1.01 and 3.0 score 1; 3.01 scores 2. magent does not assay LDH."},"stage_iii_or_iv":{"type":"boolean","description":"Ann Arbor stage III or IV as assigned by the caller (Zhou 2014 NCCN-IPI). true scores 1. magent does not stage lymphoma."},"extranodal_major":{"type":"boolean","description":"Extranodal involvement of major organs (bone marrow, CNS, liver/GI tract, or lung) as assigned by the caller (Zhou 2014 NCCN-IPI). true scores 1. This is not IPI extranodal sites >1. magent does not image extranodal sites."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_G3b2jjlzPVluye5cPWFz5","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the NCCN-IPI prognostic score for diffuse large B-cell lymphoma (DLBCL) using the Zhou 2014 refinement, returning a total score (0–8) and risk group classification.","exampleAgentPrompt":"Calculate the NCCN-IPI score for a 68-year-old DLBCL patient with an LDH/ULN ratio of 2.4, ECOG performance status of 1, Ann Arbor stage IV disease, and major-organ extranodal involvement in the bone marrow — what risk group does that put them in?","exampleUseCases":[{"title":"Oncology chart review risk stratification","prompt":"I'm reviewing a DLBCL patient who is 72 years old, has an LDH/ULN ratio of 1.8, ECOG status of 2, is stage III, and has no major-organ extranodal sites — can you calculate their NCCN-IPI score and tell me which risk group they fall into?"},{"title":"Clinical trial eligibility screening","prompt":"We need the NCCN-IPI risk group for a 55-year-old DLBCL patient: LDH/ULN ratio 3.5, ECOG 0, Ann Arbor stage II, no major-organ extranodal involvement — run the Zhou 2014 NCCN-IPI calculation."},{"title":"Tumor board case presentation prep","prompt":"For our tumor board, can you compute the NCCN-IPI score for a 43-year-old patient with DLBCL, LDH/ULN ratio of 0.9, ECOG 1, Ann Arbor stage IV, and lung involvement as an extranodal major organ site?"}],"resultDescription":"Returns the computed NCCN-IPI total score (integer 0–8) and the corresponding risk group classification: low (0–1), low_intermediate (2–3), high_intermediate (4–5), or high (6–8), based on the Zhou 2014 rituximab-era refinement of the International Prognostic Index for DLBCL.","failureModes":["Missing required query parameters (age, ecog, ldh_uln_ratio, stage_iii_or_iv, extranodal_major) returns a validation error","Age outside 18–120 range or LDH/ULN outside 0.1–20 range may trigger schema validation failure","ECOG value outside 0–4 may be rejected","Payment failure or insufficient USDC balance returns a 402 error","Network timeout if the API is temporarily unavailable"],"whenToPreferThis":"Use this endpoint when you need a deterministic, published NCCN-IPI score (Zhou 2014 refinement) for a DLBCL patient in the rituximab era — particularly when you want the refined four-tier age scoring rather than the binary >60 cutoff in the original Shipp IPI. Prefer this over sibling endpoints (Shipp 1993 IPI, R-IPI, CNS-IPI) when the clinical question specifically concerns NCCN-IPI risk stratification as defined by Zhou 2014. This endpoint is pure computation — the caller must supply all pre-assessed clinical values (ECOG, stage, LDH/ULN, extranodal status); it does not interpret labs or imaging.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T13:09:51.215Z","isFirstParty":false}