{"uid":"cap_gnLJD5-AstLM9bC01lLN2","slug":"magent-smm-2-20-20-risk-calculator-lakshman-2018-5c4974e4","name":"Magent SMM 2/20/20 Risk Calculator (Lakshman 2018)","description":"Lakshman 2018 2/20/20 smoldering myeloma risk: one point each for BMPC >20%, serum M-protein >2 g/dL, and involved/uninvolved FLC ratio >20 (strict greater-than). 0 factors low (median TTP 110 months), 1 intermediate (68), 2 or 3 high (29). Not Mayo 70/20, not PETHEMA, not myeloma ISS, not a treatment order. BMPC 10-59 and FLC 0.01-99.9 (IMWG 2014 SLiM myeloma is rejected). magent does not assay marrow, M-protein, or free light chains.","url":"https://api.magentlab.com/api/calc/smm_22020","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["bmpc_percent","m_protein_g_dl","flc_ratio"],"properties":{"flc_ratio":{"type":"number","description":"Involved/uninvolved serum free light-chain ratio as assigned by the caller (0.01-99.9). >20 scores 1 (Lakshman 2018 2/20/20). 20 scores 0. 100 or above is IMWG 2014 myeloma and is rejected, not scored. magent does not assay free light chains."},"bmpc_percent":{"type":"number","description":"Bone-marrow plasma cells as a percent (10-59). >20 scores 1 (Lakshman 2018 2/20/20). 20 scores 0. 10 is the SMM floor. 60 or above is IMWG 2014 myeloma and is rejected, not scored. magent does not read a marrow."},"m_protein_g_dl":{"type":"number","description":"Serum M-protein in g/dL (0-15). >2 scores 1 (Lakshman 2018 2/20/20). 2 scores 0. magent does not assay M-protein."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_5R9UbhmIAU1wHFp8M7ZkH","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Calculates smoldering multiple myeloma (SMM) progression risk score using the Lakshman 2018 2/20/20 model from caller-supplied BMPC percentage, serum M-protein, and FLC ratio","exampleAgentPrompt":"Score this smoldering myeloma patient using the Lakshman 2018 2/20/20 model — bone marrow plasma cells are 35%, serum M-protein is 2.8 g/dL, and the involved/uninvolved free light-chain ratio is 25.","exampleUseCases":[{"title":"Hematology clinic SMM risk triage","prompt":"I just reviewed a smoldering myeloma patient: BMPC is 45%, M-protein is 1.5 g/dL, and FLC ratio is 18. Can you run the Lakshman 2/20/20 score and tell me if they're low, intermediate, or high risk and what the expected time to progression is?"},{"title":"Research cohort risk stratification","prompt":"For our SMM study cohort entry, apply the 2/20/20 Lakshman 2018 model to these values: bone marrow plasma cells 22%, serum M-protein 2.1 g/dL, FLC ratio 30. What risk group does this patient fall into?"},{"title":"Clinical note generation for oncology EHR","prompt":"Before I write up this patient's note, calculate their smoldering myeloma 2/20/20 risk score — BMPC is 15%, M-protein is 3.2 g/dL, and FLC ratio is 12 — and give me the risk tier and median time-to-progression figure."}],"resultDescription":"Returns the computed 2/20/20 integer risk score (0, 1, 2, or 3), the corresponding risk category (low for 0, intermediate for 1, high for 2-3), and the associated median time-to-progression in months (110, 68, or 29 respectively). Inputs outside valid SMM ranges (BMPC <10 or ≥60, FLC ratio ≥100) are rejected as myeloma or out-of-scope.","failureModes":["BMPC ≥60% rejected — meets IMWG 2014 SLiM myeloma threshold, not SMM","FLC ratio ≥100 rejected — meets myeloma criteria, out of SMM scoring range","BMPC <10% rejected — below SMM floor","Missing required query parameters (bmpc_percent, m_protein_g_dl, flc_ratio) returns error","Values at exactly 20 (BMPC), 2 (M-protein), or 20 (FLC) score 0 points each (strict greater-than rule)","Non-numeric or out-of-range parameter types return validation error"],"whenToPreferThis":"Use this endpoint when you need to apply specifically the Lakshman 2018 2/20/20 risk model to a smoldering multiple myeloma patient with known BMPC%, serum M-protein, and FLC ratio values. Prefer this over Mayo 70/20 or PETHEMA calculators when the clinical context calls for the 2/20/20 stratification scheme. Do not use for confirmed myeloma (CRAB criteria or SLiM-positive), for treatment ordering, or if you need actual lab assay results — this calculator only scores caller-supplied values.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-15T07:06:49.098Z","isFirstParty":false}