{"uid":"cap_g-ssbAMYskZL_dRZvYdCO","slug":"pardanani-2018-maps-hybrid-prognostic-score-for-systemic-mastocytosis-c8278e04","name":"Pardanani 2018 MAPS Hybrid Prognostic Score for Systemic Mastocytosis","description":"Pardanani 2018 MAPS hybrid clinical-molecular (Figure 3): advanced SM 2 (ASM, SM-AHN, or MCL; ISM/SSM 0), age >60 1, platelets <150×10^9/L 1, ALP above UNL 1, ASXL1/RUNX1/NRAS 1; max 6. Low ≤2, intermediate-1 3, intermediate-2 4, high ≥5. Not WHO SM, not ICC SM, not clinical-only Figure 1. magent does not sequence, assay ALP, or count platelets.","url":"https://api.magentlab.com/api/calc/maps","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["sm_category","age","platelets_10e9_l","alp_above_unl","adverse_mutations"],"properties":{"age":{"type":"integer","description":"Age in years (18-120, Params.age). >60 scores 1 (Pardanani 2018 Figure 3). 60 is the ≤60 arm and scores 0."},"sm_category":{"type":"string","description":"Caller-assigned SM category for Pardanani 2018 hybrid Figure 3. indolent (ISM/SSM) scores 0. advanced (ASM, SM-AHN, or MCL) scores 2. Other tokens are invalid_maps. Not WHO SM criteria. magent does not assign WHO or ICC SM."},"alp_above_unl":{"type":"boolean","description":"Serum alkaline phosphatase above the upper normal limit as assigned by the caller (Pardanani 2018 Figure 3). true scores 1. magent does not assay ALP."},"platelets_10e9_l":{"type":"number","description":"Platelet count in 10^9/L (1-2000). <150 scores 1 (Pardanani 2018 Figure 3). 150.0 is the ≥150 arm and scores 0. magent does not assay platelets."},"adverse_mutations":{"type":"boolean","description":"ASXL1, RUNX1, or NRAS as assigned by the caller (Pardanani 2018 hybrid Figure 3). true scores 1. magent does not sequence."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_W-j2S1UGiv_Tr0WH9wQtI","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Calculates the Pardanani 2018 MAPS hybrid clinical-molecular prognostic score (Figure 3) for systemic mastocytosis, returning a numeric score and risk tier (Low/Intermediate-1/Intermediate-2/High).","exampleAgentPrompt":"Calculate the Pardanani 2018 MAPS hybrid score for a 68-year-old patient with advanced SM (ASM), platelets of 110×10^9/L, alkaline phosphatase above the upper normal limit, and a confirmed ASXL1 mutation.","exampleUseCases":[{"title":"Stratifying newly diagnosed ASM patient","prompt":"I have a 72-year-old patient with aggressive systemic mastocytosis, platelet count of 90, ALP that's above normal, and an NRAS mutation confirmed on sequencing — what's their MAPS score and risk tier?"},{"title":"Prognostic scoring for SM-AHN workup","prompt":"Run the Pardanani MAPS score for a 55-year-old with SM-AHN: platelets are 200, ALP is within normal limits, no ASXL1/RUNX1/NRAS mutations found."},{"title":"Comparing indolent SM patient at risk boundary","prompt":"What does the MAPS hybrid score come out to for a 61-year-old with indolent SM, platelet count of 145, normal ALP, and no adverse mutations?"}],"resultDescription":"Returns the computed MAPS total score (integer 0-6), the corresponding risk tier label (Low ≤2, Intermediate-1 = 3, Intermediate-2 = 4, High ≥5), and per-variable point contributions based on Pardanani 2018 Figure 3.","failureModes":["Invalid sm_category token (not 'indolent' or 'advanced') returns invalid_maps error","Age outside 18-120 range causes validation failure","Platelet count outside 1-2000 range causes validation failure","Missing required query parameters returns 400-level error","Caller-supplied clinical data that is inconsistent (e.g. platelets=0) may cause rejection"],"whenToPreferThis":"Use this endpoint when you need to apply the Pardanani 2018 MAPS hybrid clinical-molecular prognostic model (Figure 3) specifically — combining SM category, age, platelet count, ALP status, and ASXL1/RUNX1/NRAS mutation status. Prefer this over clinical-only or WHO/ICC-criteria-based tools when the hybrid score is explicitly required. Note: this endpoint does not perform sequencing, platelet counting, or ALP assay — callers must supply pre-determined values.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T07:14:53.923Z","isFirstParty":false}