{"uid":"cap_dPJssc6zbfGtPWMvH3NbO","slug":"greipp-2005-iss-myeloma-staging-calculator-75a72bcd","name":"Greipp 2005 ISS Myeloma Staging Calculator","description":"Greipp 2005 International Staging System for multiple myeloma. Stage I: serum beta-2 microglobulin <3.5 mg/L and albumin >=3.5 g/dL. Stage III: beta-2 microglobulin >=5.5 mg/L. Stage II: neither I nor III. Returns iss_stage 1/2/3. Not a myeloma diagnosis or treatment choice; not R-ISS (no LDH, no cytogenetics); not trauma ISS. magent does not assay beta-2 microglobulin or albumin.","url":"https://api.magentlab.com/api/calc/myeloma_iss","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["beta2_microglobulin_mg_l"],"properties":{"albumin_g_l":{"type":"number","description":"Serum albumin in g/L (10-60). Converted as g/dL = g/L / 10. Provide this or albumin_g_dl, not both."},"albumin_g_dl":{"type":"number","description":"Serum albumin in g/dL (1-6). Provide this or albumin_g_l, not both. Greipp 2005 stages use g/dL. Stage I requires albumin >= 3.5 when Sβ2M < 3.5. Ignored when Sβ2M >= 5.5."},"beta2_microglobulin_mg_l":{"type":"number","description":"Serum beta-2 microglobulin in mg/L (0.2-40). Greipp 2005 Sβ2M. Stage I requires < 3.5; stage III when >= 5.5. magent does not assay beta-2 microglobulin."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":{"type":"json","example":{"path":"/api/calc/myeloma_iss","count":2,"items":[{"formula":"myeloma_iss","citation":{"id":"greipp-2005","doi":"10.1200/JCO.2005.04.242","pmid":"15809451","title":"International staging system for multiple myeloma","source":"J Clin Oncol. 2005;23(15):3412-3420","authors":"Greipp PR, San Miguel J, Durie BGM, Crowley JJ, Barlogie B, Bladé J, Boccadoro M, Child JA, Avet-Loiseau H, Kyle RA, Lahuerta JJ, Ludwig H, Morgan G, Powles R, Shimizu K, Shustik C, Sonneveld P, Tosi P, Turesson I, Westin J"},"iss_stage":1,"disclaimer":"Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.","albumin_g_dl":4,"iss_stage_label":"I","formula_expression":"ISS stage I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; stage III: beta2_microglobulin_mg_l >= 5.5; stage II: neither I nor III (Greipp 2005)","beta2_microglobulin_mg_l":2},{"formula":"myeloma_iss","citation":{"id":"greipp-2005","doi":"10.1200/JCO.2005.04.242","pmid":"15809451","title":"International staging system for multiple myeloma","source":"J Clin Oncol. 2005;23(15):3412-3420","authors":"Greipp PR, San Miguel J, Durie BGM, Crowley JJ, Barlogie B, Bladé J, Boccadoro M, Child JA, Avet-Loiseau H, Kyle RA, Lahuerta JJ, Ludwig H, Morgan G, Powles R, Shimizu K, Shustik C, Sonneveld P, Tosi P, Turesson I, Westin J"},"iss_stage":1,"disclaimer":"Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.","albumin_g_dl":4,"iss_stage_label":"I","formula_expression":"ISS stage I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; stage III: beta2_microglobulin_mg_l >= 5.5; stage II: neither I nor III (Greipp 2005)","beta2_microglobulin_mg_l":2}]}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_Us7BwyF3dbUnJ5GZlwBZD","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the International Staging System (ISS) stage (I, II, or III) for multiple myeloma from serum beta-2 microglobulin and albumin values per Greipp 2005 criteria.","exampleAgentPrompt":"What is the ISS myeloma stage for a patient with a serum beta-2 microglobulin of 4.2 mg/L and a serum albumin of 3.8 g/dL using the Greipp 2005 criteria?","exampleUseCases":[{"title":"Myeloma staging during oncology consult","prompt":"I have a myeloma patient with beta-2 microglobulin of 2.8 mg/L and albumin of 4.0 g/dL — what ISS stage are they?"},{"title":"Automated staging in EHR pipeline","prompt":"For my patient with serum beta-2 microglobulin 6.1 mg/L and albumin 3.0 g/dL, calculate their Greipp 2005 ISS myeloma stage so I can document it in the chart."},{"title":"Research cohort risk stratification","prompt":"I need to assign ISS stages to a series of myeloma patients — starting with one who has beta-2 microglobulin 3.3 mg/L and albumin 3.6 g/dL, what stage do they get?"}],"resultDescription":"Returns iss_stage as an integer (1, 2, or 3) representing the ISS stage per Greipp 2005: Stage I (beta-2 microglobulin <3.5 mg/L and albumin ≥3.5 g/dL), Stage III (beta-2 microglobulin ≥5.5 mg/L), and Stage II (neither I nor III).","failureModes":["Missing required beta2_microglobulin_mg_l parameter returns an error","Providing both albumin_g_l and albumin_g_dl simultaneously is rejected","Values outside accepted ranges (e.g. beta-2 microglobulin outside 0.2–40 mg/L, albumin outside 1–6 g/dL) may return validation errors","No albumin provided when beta-2 microglobulin is below 5.5 and staging requires it may produce ambiguous output"],"whenToPreferThis":"Use this endpoint when you need to apply the classic Greipp 2005 ISS criteria (Stage I/II/III) to lab values for multiple myeloma staging. Prefer this over R-ISS calculators when LDH and cytogenetics data are unavailable or not required. Do not use for trauma ISS scoring, myeloma diagnosis, or treatment selection.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-15T01:19:45.943Z","isFirstParty":false}