{"uid":"cap_cojuBnsiTLiyoPJUQpAEn","slug":"synthora-pubmed-e-utilities-search-4c37c136","name":"SYNTHORA PubMed E-utilities Search","description":"Searches PubMed's 37M+ biomedical citations via NCBI E-utilities esearch, returning matching PMIDs, result counts and MeSH query translation as JSON. Core keyless endpoint for autonomous biomedical research agents and agent-to-agent literature-triage pipelines needing a ranking surface over clinical and life-science literature. First 3 calls FREE per wallet — send header X-WALLET: 0x<addr>. No charge on upstream failure.","url":"https://pubmed-esearch.hergertsynthora.com/service","method":"POST","headers":{},"bodySchema":{"type":"object","properties":{"query":{"type":"string","description":"query"}}},"responseSchema":{"type":"json","example":{"ok":true,"niche":"pubmed-esearch","result":{}}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.001","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.001/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.001","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.001","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_6eIV0VUCvWZnXVbv6Y8FT","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.001","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Searches PubMed's 37M+ biomedical citations via NCBI E-utilities esearch, returning matching PMIDs, result counts, and MeSH query translation as JSON","exampleAgentPrompt":"Search PubMed for papers on CRISPR-based gene therapy for sickle cell disease and give me the matching PMIDs, total result count, and how PubMed translated my query into MeSH terms.","exampleUseCases":[{"title":"Drug interaction literature triage","prompt":"Search PubMed for all citations on metformin and lactic acidosis — I need the PMIDs, how many results there are, and the MeSH terms PubMed mapped my query to."},{"title":"Rare disease research discovery","prompt":"Can you query PubMed for papers about Niemann-Pick disease type C and return the list of PMIDs and total hit count so I can pull the full records next?"},{"title":"Clinical agent literature pipeline","prompt":"Run a PubMed esearch for randomized controlled trials on cognitive behavioral therapy for treatment-resistant depression and give me the PMID list and MeSH query translation."}],"resultDescription":"A JSON object with an 'ok' boolean, a 'niche' field confirming 'pubmed-esearch', and a 'result' object containing the NCBI esearch response — including a list of matching PMIDs, the total count of results, and the MeSH-translated query string used by PubMed.","failureModes":["Empty result set if query terms are too specific or misspelled","NCBI rate limiting or downtime causing upstream errors","Malformed query string leading to zero results or API rejection","Payment failure (x402) if USDC balance is insufficient","Result object may be empty or partial if NCBI esearch returns an error code"],"whenToPreferThis":"Choose this endpoint when you need fast, keyless programmatic access to PubMed's esearch functionality — especially in autonomous biomedical research agents or agent-to-agent literature-triage pipelines where you want PMIDs, result counts, and MeSH translation in a single JSON call without managing NCBI API credentials. Prefer it over direct NCBI API calls when operating in a microtransaction/x402 payment context or when routing through a standardized agent tool interface.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-13T18:33:26.708Z","isFirstParty":false}