{"uid":"cap_c0tkinY9JlUhVSuujgRAN","slug":"saylor-innovations-bioinformatics-gene-variant-list-by-clinical-8bbc5660","name":"Saylor Innovations Bioinformatics: Gene Variant List by Clinical Significance (ClinVar)","description":"Gene Variant List by Clinical Significance (ClinVar). ClinVar variants for a gene, filtered by clinical significance (pathogenic, likely_pathogenic, uncertain, benign, likely_benign, conflicting): total count in ClinVar plus the latest records with classification, review stars, conditions and protein change. 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Can you pull the latest records with their review ratings and associated conditions?"},{"title":"Compare likely benign variant counts","prompt":"How many likely benign variants does ClinVar have for CFTR? Can you also show me the most recent records with their clinical classifications and protein changes?"}],"resultDescription":"Returns a JSON object with a 'found' boolean, the total count of matching variants in ClinVar, and an array of variant records each containing clinical classification, review star rating, associated conditions, and protein change information","failureModes":["Invalid or unrecognized gene symbol returns found=false with empty variants array","Invalid significance value returns an error or empty result","Gene with no ClinVar entries returns found=false","NCBI ClinVar upstream outage may cause timeout or empty response","Missing required gene parameter returns a validation error"],"whenToPreferThis":"Use this endpoint when you need structured ClinVar variant data for a specific gene filtered by clinical significance category. It is ideal for genomic research workflows, clinical decision support tools, or bioinformatics agents that need to quickly surface pathogenic, benign, or uncertain variant records without building a direct NCBI ClinVar API integration. Prefer this over raw NCBI queries when you want pre-filtered, pay-per-call simplicity with protein change and condition metadata bundled in one response.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-10-01T12:55:19.825Z","isFirstParty":false,"canonicalSlug":"saylor-innovations-bioinformatics-gene-variant-list-by-clinical-8bbc5660"}