{"uid":"cap_bg59gGuEuLH3qYSkGKzx-","slug":"fda-faers-drug-safety-signal-detection-prr-37a375f5","name":"FDA FAERS Drug Safety Signal Detection (PRR)","description":"Drug safety signal detection (pharmacovigilance) from FDA FAERS: side effects reported disproportionately often with a drug versus all other drugs, using the proportional reporting ratio (PRR) and chi-square with standard Evans criteria. A statistical prompt for study, not evidence of harm. Not medical advice.","url":"https://www.x402pulse.dev/v1/health/safety-signals?utm_source=zero.xyz","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET"],"type":"string"},"queryParams":{"type":"object","required":["drug"],"properties":{"drug":{"type":"string","description":"Drug brand or generic name"}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":{"type":"json","example":{"data":{"drug":"atorvastatin","method":"Proportional reporting ratio vs. all other drugs in FAERS (Evans criteria).","signals":[{"prr":14.2,"signal":true,"reports":2020,"reaction":"rhabdomyolysis","chiSquare":2650.4}],"drugReports":52000,"signalCount":3,"reactionsChecked":25},"cached":false}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.0875","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.0875/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.0875","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.0875","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_fjZgfzTvbMdJhL9sxkRdl","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.0875","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Detects adverse drug reaction signals from FDA FAERS data using Proportional Reporting Ratio (PRR) and chi-square with Evans criteria to identify side effects reported disproportionately often for a specific drug.","exampleAgentPrompt":"Can you pull the FDA FAERS safety signals for metformin — I want to see which side effects are reported disproportionately often compared to all other drugs, using the PRR and Evans criteria.","exampleUseCases":[{"title":"Pre-prescribing adverse event review","prompt":"Before I discuss ozempic with my doctor, can you show me which adverse events are flagged as disproportionate signals in FDA FAERS data for that drug, based on the proportional reporting ratio?"},{"title":"Pharmacology research literature prep","prompt":"I'm writing a report on warfarin safety — can you pull the PRR-based pharmacovigilance signals from FDA FAERS so I can see which side effects stand out statistically compared to all other drugs?"},{"title":"Drug comparison safety screening","prompt":"I want to compare the safety signal profiles of lisinopril and losartan — start by getting me the FDA FAERS PRR signals for lisinopril so I can see which adverse events meet the Evans criteria."}],"resultDescription":"Returns a list of adverse event terms (MedDRA or similar) that are reported disproportionately often with the queried drug versus all other drugs in FDA FAERS, along with their PRR values, chi-square statistics, and whether each signal meets the standard Evans criteria thresholds. Includes a disclaimer that results are statistical signals for study, not evidence of causality or medical advice.","failureModes":["Drug name not found in FAERS database — returns empty or no-signal response","Misspelled or unrecognized drug name — may return no results","Drug with very few FAERS reports — insufficient data for reliable PRR computation","Rate limiting if fair-use thresholds exceeded","Network timeout on FAERS data retrieval"],"whenToPreferThis":"Choose this endpoint when you need a quantitative, statistically grounded adverse event signal analysis for a specific drug using the industry-standard PRR and Evans criteria methodology applied to the FDA FAERS database. Prefer it over raw label lookups (which give approved warnings) when you want empirical post-market reporting patterns. It is not a replacement for clinical judgment or FDA-approved labeling.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-10-12T18:43:41.540Z","isFirstParty":false,"canonicalSlug":"fda-faers-drug-safety-signal-detection-prr-37a375f5"}