{"uid":"cap_bcbtcRRLpSTqOYm_X6MP2","slug":"mipss70-score-calculator-for-primary-myelofibrosis-guglielmelli-2018-34dd037d","name":"MIPSS70 Score Calculator for Primary Myelofibrosis (Guglielmelli 2018)","description":"Guglielmelli 2018 MIPSS70 for transplant-age PMF: Hb <10 g/dL (1), leukocytes >25×10^9/L (2), platelets <100×10^9/L (2), blasts ≥2% (1), fibrosis ≥2 (1), symptoms (1), no type 1/like CALR (1), HMR category (1), ≥2 HMR (2); max 12. Low 0–1, intermediate 2–4, high ≥5. Italian-cohort median (5-year) OS 27.7 y (95%), 7.1 y (70%), 2.3 y (29%). Not MIPSS70-plus or version 2.0. magent does not sequence or grade marrow.","url":"https://api.magentlab.com/api/calc/mipss70","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["leukocytes_10e9_l","platelets_10e9_l","blasts_percent","fibrosis_grade","constitutional_symptoms","calr_type1_like","hmr_mutation_count"],"properties":{"blasts_percent":{"type":"number","description":"Circulating blasts as a percent (0-30). ≥2 scores 1 (Guglielmelli 2018). 2.0 scores; 1.9 is the <2 arm and scores 0. magent does not read a smear."},"fibrosis_grade":{"type":"integer","description":"WHO bone-marrow fibrosis grade as an integer 0-3, assigned by the caller (Guglielmelli 2018). ≥2 scores 1. Grade 2 scores; grade 1 scores 0. magent does not grade marrow."},"hemoglobin_g_l":{"type":"number","description":"Hemoglobin in g/L (30-220). Converted as hemoglobin_g_dl = hemoglobin_g_l / 10. Provide this or hemoglobin_g_dl, not both. <100 g/L scores 1. 100 is the ≥100 arm and scores 0."},"calr_type1_like":{"type":"boolean","description":"Presence of a type 1/like CALR mutation as assigned by the caller (Guglielmelli 2018). false (absence) scores 1. true scores 0. magent does not sequence."},"hemoglobin_g_dl":{"type":"number","description":"Hemoglobin in g/dL (3-22). Provide this or hemoglobin_g_l, not both. <10 g/dL (<100 g/L) scores 1 (Guglielmelli 2018). 10.0 is the ≥10 arm and scores 0. magent does not assay hemoglobin."},"platelets_10e9_l":{"type":"number","description":"Platelet count in 10^9/L (1-2000). <100 scores 2 (Guglielmelli 2018). 100.0 is the ≥100 arm and scores 0. magent does not assay platelets."},"leukocytes_10e9_l":{"type":"number","description":"Leukocyte count in 10^9/L (0.5-200). >25 scores 2 (Guglielmelli 2018). 25.0 is the ≤25 arm and scores 0. magent does not assay leukocytes."},"hmr_mutation_count":{"type":"integer","description":"Count of high-molecular-risk mutations among ASXL1, EZH2, SRSF2, IDH1, and IDH2 as assigned by the caller (integer 0-5). ≥1 scores 1 (HMR category). ≥2 scores an additional 2 (two or more HMR mutations), so a count of 2 or more contributes 3. Count 0 scores 0. magent does not sequence."},"constitutional_symptoms":{"type":"boolean","description":"Constitutional symptoms as assigned by the caller (Guglielmelli 2018). true scores 1. magent does not take a history."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_iTQrjjIFl6YLEtoRTgXsv","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the Mutation-Enhanced International Prognostic Score System (MIPSS70) for transplant-eligible PMF patients, returning a total score, risk category, and Italian-cohort survival estimates.","exampleAgentPrompt":"Calculate the MIPSS70 score for my PMF patient: hemoglobin 8.5 g/dL, leukocytes 30×10^9/L, platelets 80×10^9/L, circulating blasts 3%, bone marrow fibrosis grade 2, constitutional symptoms present, no type 1/like CALR mutation, 2 HMR mutations — what's the risk category and expected survival?","exampleUseCases":[{"title":"Pre-transplant PMF risk stratification","prompt":"I have a transplant-eligible PMF patient: Hgb 9.2 g/dL, WBC 28×10^9/L, platelets 90×10^9/L, blasts 2.5%, fibrosis grade 3, has constitutional symptoms, no type 1/like CALR mutation, and 1 HMR mutation. Run the MIPSS70 and tell me the risk group and 5-year OS."},{"title":"Monitoring disease progression over time","prompt":"My PMF patient's labs changed — now Hgb 10.5 g/dL, leukocytes 20×10^9/L, platelets 110×10^9/L, 1% blasts, grade 1 fibrosis, no symptoms, type 1 CALR mutation present, 0 HMR mutations. Recalculate the MIPSS70 score to see if the risk category improved."},{"title":"Comparing patients for transplant prioritization","prompt":"Score this PMF patient using MIPSS70 Guglielmelli 2018: hemoglobin 85 g/L, leukocytes 26×10^9/L, platelets 55×10^9/L, 4% circulating blasts, fibrosis grade 2, constitutional symptoms yes, CALR type 1/like absent, 3 or more HMR mutations — I need the total point score and the Italian cohort median OS."}],"resultDescription":"Returns a MIPSS70 integer total score (max 12), a risk category (Low: 0–1, Intermediate: 2–4, High: ≥5), and Italian-cohort survival statistics including median overall survival and 5-year OS rate (Low: 27.7 yr / 95%; Intermediate: 7.1 yr / 70%; High: 2.3 yr / 29%).","failureModes":["Missing required query parameters (leukocytes, platelets, blasts, fibrosis grade, symptoms, CALR status, HMR count) returns validation error","Providing both hemoglobin_g_dl and hemoglobin_g_l simultaneously causes conflict error","Out-of-range values (e.g. blasts >30%, fibrosis grade >3, leukocytes <0.5) may trigger validation rejection","Omitting hemoglobin entirely may return an incomplete score or error","x402 payment failure if USDC balance is insufficient"],"whenToPreferThis":"Use this endpoint when you need the Guglielmelli 2018 MIPSS70 score specifically for transplant-age (≤70) PMF patients and have caller-assigned mutation data (CALR type, HMR count) and CBC values. Prefer this over MIPSS70-plus or version 2.0 endpoints when the original Italian-cohort survival benchmarks are required. Not suitable for post-ET/PV MF or when bone marrow grading has not yet been assigned by a pathologist.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T13:09:20.960Z","isFirstParty":false}