{"uid":"cap_aoxh0x8k_M7cZY0ofIwUd","slug":"astct-icans-consensus-grade-calculator-adult-lee-2019-0145a5c9","name":"ASTCT ICANS Consensus Grade Calculator (Adult, Lee 2019)","description":"Adult ASTCT ICANS consensus grade (Lee 2019 Table 6). Grade is the most severe of ICE, depressed LOC, seizure, deep focal motor weakness, and ICP/edema. ICE 10 is 0; 7-9 is 1; 3-6 is 2; 0-2 is 3; ICE 0 is 4 if unarousable. Not CRS, not pediatric CAPD, and not the 10-item ICE test. magent does not perform ICE testing or examine the patient. Not a medical device.","url":"https://api.magentlab.com/api/calc/astct_icans","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["ice_score","loc","seizure","motor_weakness","icp"],"properties":{"icp":{"enum":["none","focal_edema","diffuse_edema"],"type":"string","description":"Caller-assigned raised intracranial pressure / cerebral edema (Lee 2019 Table 6): none (domain 0); focal_edema (focal/local edema on neuroimaging, 3); diffuse_edema (diffuse cerebral edema on imaging, or decerebrate/decorticate posturing, cranial nerve VI palsy, papilledema, or Cushing triad, 4). Case-insensitive. magent does not read imaging or examine the patient."},"loc":{"enum":["none","spontaneous","voice","tactile","unarousable"],"type":"string","description":"Caller-assigned depressed level of consciousness (Lee 2019 Table 6): none (no depressed LOC, domain 0); spontaneous (awakens spontaneously, 1); voice (awakens to voice, 2); tactile (awakens only to tactile stimulus, 3); unarousable (unarousable or requires vigorous or repetitive tactile stimuli; stupor or coma, 4). Case-insensitive. magent does not examine the patient."},"seizure":{"enum":["none","rapidly_resolving","life_threatening"],"type":"string","description":"Caller-assigned seizure (Lee 2019 Table 6): none (domain 0); rapidly_resolving (any clinical seizure, focal or generalized, that resolves rapidly, or nonconvulsive seizures on EEG that resolve with intervention, 3); life_threatening (life-threatening prolonged seizure >5 min or repetitive clinical or electrical seizures without return to baseline, 4). Case-insensitive. magent does not interpret EEG."},"ice_score":{"type":"integer","description":"Caller-assigned Immune Effector Cell-Associated Encephalopathy (ICE) total 0-10 (Lee 2019 Table 6). Domain: 10 → grade 0; 7-9 → 1; 3-6 → 2; 0-2 → 3. ICE 0 is grade 3 if awake (loc is not unarousable) and grade 4 if unarousable/unable to perform ICE. magent does not score orientation, naming, following commands, writing, or attention and is not the 10-item ICE calculator."},"motor_weakness":{"type":"boolean","description":"Deep focal motor weakness such as hemiparesis or paraparesis as assigned by the caller (Lee 2019 Table 6). true maps to domain grade 4. false maps to 0. Motor is N/A for grades 1-3. true or false. magent does not examine the patient."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_KVsXXaDYqLbQ6jncSFA6V","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the adult ASTCT ICANS consensus grade (0–4) from five caller-supplied domain scores: ICE score, level of consciousness, seizure, motor weakness, and ICP/edema.","exampleAgentPrompt":"Grade the ICANS for a CAR-T patient with an ICE score of 5, level of consciousness awakening to voice, no seizures, no focal motor weakness, and no ICP or edema — give me the ASTCT consensus grade.","exampleUseCases":[{"title":"CAR-T neurotoxicity triage","prompt":"My patient just received CAR-T therapy and has an ICE score of 3, only wakes up to tactile stimulation, no seizures, no focal motor weakness, and diffuse cerebral edema on imaging — what is the ICANS grade?"},{"title":"Clinical trial automated ICANS scoring","prompt":"For our CAR-T trial data pipeline, calculate the ASTCT ICANS grade for a participant with ICE score 9, spontaneous awakening, no seizure, no motor weakness, and no ICP findings."},{"title":"Complete neurotoxicity assessment at grade boundary","prompt":"Can you work out the ICANS grade for a patient with ICE score 0, unarousable level of consciousness, a rapidly resolving seizure, no focal motor weakness, and focal edema on neuroimaging?"}],"resultDescription":"Returns the overall ICANS grade (0–4) as the maximum severity across the five domains (ICE, depressed LOC, seizure, deep focal motor weakness, ICP/edema), along with per-domain grade values, consistent with Lee 2019 Table 6 criteria.","failureModes":["Missing required query parameter (ice_score, loc, seizure, motor_weakness, or icp) returns a 400/422 error","ice_score out of range (not 0–10) returns a validation error","Invalid enum value for loc, seizure, motor_weakness, or icp returns an error","Network or server errors return 5xx; retry with backoff","Payment failure (x402) if USDC balance is insufficient"],"whenToPreferThis":"Use this endpoint when you need a fast, deterministic computation of the adult ASTCT ICANS consensus grade per Lee 2019 Table 6, particularly in CAR-T care workflows, clinical trial pipelines, or agentic monitoring systems. Prefer this over manual look-up tables or generic LLM reasoning when you require reproducible, schema-validated grading that can be audited. Not appropriate for pediatric CAPD grading, CRS scoring, or situations where ICE testing has not already been performed by a clinician.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-13T12:52:33.165Z","isFirstParty":false}