{"uid":"cap__WGHGkE8HWI9rpcvMnMo-","slug":"uniprot-protein-sequence-lookup-d7a16d19","name":"UniProt Protein Sequence Lookup","description":"Get the reference amino-acid sequence of a protein or an isoform by UniProt accession, with its length, weight, checksums and isoforms.","url":"https://win.oneshotagent.com/v1/tools/lookup/protein-sequence?utm_source=zero.xyz","method":"POST","headers":{},"bodySchema":{"type":"object","properties":{"accession":{"type":"string","description":"The UniProt accession, for example P04637, or an isoform accession, for example P04637-2"}}},"responseSchema":{"type":"json","example":{"protein":null,"inactive":{"reason":"demerged","replaced_by":["P99999","P99998"]}}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_RBZWt23iEOMOrdzMabUxh","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Retrieves the reference amino-acid sequence of a protein or isoform by UniProt accession, including sequence length, molecular weight, checksums, and isoform list.","exampleAgentPrompt":"Can you look up the reference amino acid sequence, length, and isoforms for the human TP53 protein using its UniProt accession P04637?","exampleUseCases":[{"title":"Validate protein identity by sequence","prompt":"I need to confirm the canonical amino acid sequence for the BRCA1 protein — can you pull it up using its UniProt accession P38398 and give me the sequence, its length, and any known isoforms?"},{"title":"Retrieve isoform sequence for analysis","prompt":"Can you fetch the sequence for isoform 2 of the human insulin receptor, UniProt accession P06213-2, including its molecular weight and checksum?"},{"title":"Gather protein metadata for a pipeline","prompt":"I'm building a bioinformatics pipeline and need the reference sequence, length, and molecular weight for the protein with UniProt accession Q9Y6K9 — can you get that for me?"}],"resultDescription":"Returns the full reference amino acid sequence for the requested protein or isoform, along with the sequence length, molecular weight, CRC64 and MD5 checksums, and a list of available isoforms associated with the UniProt accession.","failureModes":["Invalid or non-existent UniProt accession returns an error or empty result","Malformed accession format (e.g. missing dash for isoform) causes a validation error","Network or service timeout for large proteins","Payment failure if x402 micropayment is not processed correctly"],"whenToPreferThis":"Choose this endpoint when you need structured protein sequence data — including isoforms, weight, and checksums — directly from UniProt without setting up your own UniProt API integration. Ideal for AI agents that need to programmatically retrieve protein metadata as part of a bioinformatics workflow, drug discovery pipeline, or sequence validation task, especially when pay-per-call pricing is preferable to managing API keys.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-10-29T07:21:55.213Z","isFirstParty":false,"canonicalSlug":"uniprot-protein-sequence-lookup-d7a16d19"}