{"uid":"cap_ZUrT_YUoYoMhufXur4ROb","slug":"clinvar-gene-variant-finder-71e27dbf","name":"ClinVar Gene Variant Finder","description":"Find ClinVar variants in a human gene by NCBI Gene ID or official symbol.","url":"https://win.oneshotagent.com/v1/tools/find/gene-variants?utm_source=zero.xyz","method":"POST","headers":{},"bodySchema":{"type":"object","properties":{"limit":{"type":"integer","description":"Maximum number of variants returned. From 1 to 20. Defaults to `10`."},"symbol":{"type":"string","description":"Official human gene symbol, for example BRCA1; use gene_resolve for aliases. 1 to 30 characters."},"gene_id":{"type":"string","description":"NCBI Gene ID, for example 672; supply exactly one of gene_id or symbol. 1 to 12 characters."},"classification":{"enum":["pathogenic","likely_pathogenic","uncertain","likely_benign","benign","conflicting"],"type":"string","description":"ClinVar classification property filter; may include combined classifications"},"expert_panel_only":{"type":"boolean","description":"Only variants reviewed by an expert panel. Defaults to `false`."},"include_multi_gene":{"type":"boolean","description":"Include variants spanning multiple genes. Defaults to `false`."}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_drexQzY54CQghroDNEpZW","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Returns ClinVar variants associated with a human gene, filterable by clinical classification and review status, given an NCBI Gene ID or official gene symbol.","exampleAgentPrompt":"Can you find the top 10 pathogenic ClinVar variants for BRCA1, limited to those reviewed by an expert panel?","exampleUseCases":[{"title":"Oncology variant review for BRCA1","prompt":"Pull up to 15 pathogenic or likely pathogenic ClinVar variants for BRCA1, and only include ones that have been reviewed by an expert panel."},{"title":"Research filtering for uncertain variants in TP53","prompt":"Find ClinVar variants in TP53 classified as uncertain significance — give me up to 20 results and include variants that span multiple genes."},{"title":"Clinical screening for CFTR benign variants","prompt":"Look up benign ClinVar variants for NCBI Gene ID 1080, limit to 5 results, expert panel only."}],"resultDescription":"A list of ClinVar variant records associated with the specified human gene, each including variant identity, clinical classification, and review details. Results are constrained by the requested limit and any applied filters such as classification category or expert panel review status.","failureModes":["Invalid or non-existent gene symbol returns empty result or error","Supplying both gene_id and symbol simultaneously may cause ambiguous request error","Classification enum value mismatch returns validation error","Limit out of range (below 1 or above 20) returns validation error","Gene with no ClinVar entries returns empty list","Network or upstream NCBI ClinVar unavailability causes timeout or 503 error"],"whenToPreferThis":"Use this endpoint when you need to enumerate ClinVar variants for a known human gene by symbol or NCBI Gene ID, especially with filtering by clinical significance or expert panel review. Prefer this over general variant lookup endpoints when your starting point is a gene identifier rather than an HGVS expression or rsID. For resolving aliases or non-standard gene names, use the companion gene_resolve endpoint first.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-10-20T12:39:56.642Z","isFirstParty":false,"canonicalSlug":"clinvar-gene-variant-finder-71e27dbf"}