{"uid":"cap_XoC7cDIj1wOC7H83sR9u0","slug":"cerny-1987-manchester-score-for-small-cell-lung-cancer-e46d4113","name":"Cerny 1987 Manchester Score for Small-Cell Lung Cancer","description":"Cerny 1987 Manchester score for small-cell lung cancer: LDH above laboratory ULN, sodium <132 mmol/L, ALP >1.5×ULN, bicarbonate <24 mmol/L, Karnofsky <60, extensive stage; 1 point each, max 6. Good 0–1, intermediate 2–3, poor ≥4. Deterministic published score with citation; not a diagnosis; not the BRCA Manchester score. magent does not stage the cancer, assay labs, or assign Karnofsky performance status.","url":"https://api.magentlab.com/api/calc/manchester","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["ldh_gt_uln","sodium_mmol_l","alp_gt_1_5_uln","bicarbonate_mmol_l","kps","extensive_stage"],"properties":{"kps":{"type":"integer","description":"Karnofsky 1949 Performance Status 10, 20, 30, 40, 50, 60, 70, 80, 90, or 100 as assigned by the caller. Cerny 1987 scores 1 when kps is <60; 60 scores 0. Grade 0 (dead) is not scored. magent does not observe the patient."},"ldh_gt_uln":{"type":"boolean","description":"LDH exceeds the laboratory upper limit of normal as assigned by the caller (Cerny 1987). true scores 1. magent does not assay LDH or apply ULN."},"sodium_mmol_l":{"type":"number","description":"Serum sodium in mmol/L (110-160). Cerny 1987 scores 1 when sodium is <132 mmol/L; 132 scores 0."},"alp_gt_1_5_uln":{"type":"boolean","description":"ALP >1.5 × laboratory ULN as assigned by the caller (Cerny 1987). true scores 1. magent does not assay ALP or apply ULN."},"extensive_stage":{"type":"boolean","description":"Extensive-stage small-cell lung cancer as assigned by the caller (Cerny 1987). true scores 1. magent does not stage the cancer."},"bicarbonate_mmol_l":{"type":"number","description":"Serum bicarbonate in mmol/L (2-45). Cerny 1987 scores 1 when bicarbonate is <24 mmol/L; 24 scores 0."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_HAips2apARDWhlAc1ht9W","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the Cerny 1987 Manchester prognostic score for small-cell lung cancer (0–6 points) and returns a risk group (good, intermediate, or poor) based on six lab and clinical criteria.","exampleAgentPrompt":"Calculate the Cerny 1987 Manchester score for an SCLC patient: LDH is above the lab ULN, sodium is 128 mmol/L, ALP is above 1.5× ULN, bicarbonate is 21 mmol/L, Karnofsky is 50, and the disease is extensive-stage — what's the score and risk group?","exampleUseCases":[{"title":"Oncology consult prognostic assessment","prompt":"I'm seeing an SCLC patient with extensive-stage disease, sodium of 129 mmol/L, bicarbonate of 22 mmol/L, LDH above the lab's ULN, ALP not elevated beyond 1.5×ULN, and a Karnofsky of 40 — can you run the Cerny Manchester score and tell me the prognosis group?"},{"title":"Clinical trial eligibility risk stratification","prompt":"For our SCLC trial, stratify this patient using the 1987 Manchester criteria: LDH above ULN, sodium 135 mmol/L, ALP within 1.5×ULN, bicarbonate 25 mmol/L, Karnofsky 70, limited-stage disease — give me the total score and group."},{"title":"EMR-integrated tumor board summary","prompt":"Before our tumor board, compute the Manchester SCLC prognostic score for a patient with sodium 130 mmol/L, bicarbonate 20 mmol/L, LDH high, ALP high (above 1.5×ULN), KPS of 50, and extensive-stage disease — I need the numeric score and whether it's good, intermediate, or poor."}],"resultDescription":"Returns the total Manchester score (integer 0–6) and a risk group label — good (0–1 points), intermediate (2–3 points), or poor (≥4 points) — derived deterministically from the six Cerny 1987 criteria. Does not provide a diagnosis, stage cancer, assay labs, or assign Karnofsky status.","failureModes":["Missing required query parameters (ldh_gt_uln, sodium_mmol_l, alp_gt_1_5_uln, bicarbonate_mmol_l, kps, extensive_stage) returns a 400 error","Sodium outside 110–160 mmol/L or bicarbonate outside 2–45 mmol/L returns a validation error","KPS value not in valid Karnofsky decile set (10–100) returns an error","Payment not provided or insufficient for x402 endpoint returns a 402 Payment Required response","Network timeouts on the api.magentlab.com endpoint"],"whenToPreferThis":"Use this endpoint when you need a deterministic, citation-backed computation of the Cerny 1987 Manchester prognostic score specifically for small-cell lung cancer. Prefer it over manual calculation to avoid arithmetic errors. Do not use it for BRCA risk (Manchester score by Evans et al.), HCC staging (Milan criteria), or other lung cancer histologies. Best suited when caller has already obtained lab values and clinical staging.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-15T13:13:27.884Z","isFirstParty":false}