{"uid":"cap_XhcSMDo-36cy14OICicFL","slug":"protein-function-lookup-by-uniprot-accession-219cac6b","name":"Protein Function Lookup by UniProt Accession","description":"Look up a protein’s function, literature citations, organism, cellular locations and catalytic activities by accession.","url":"https://win.oneshotagent.com/v1/tools/lookup/protein-function?utm_source=zero.xyz","method":"POST","headers":{},"bodySchema":{"type":"object","properties":{"accession":{"type":"string","description":"The UniProt accession identifying the protein, for example P04637"},"include_sequence":{"type":"boolean","description":"Include the amino-acid sequence. Defaults to `false`."}}},"responseSchema":{"type":"json","example":{"protein":null,"inactive_reason":{"reason_type":"DEMERGED","replacement_accessions":["P68251","P68250"]}}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_uHtV1a-LkOSCa18uByJEb","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Retrieves a protein's function, literature citations, organism, cellular locations, and catalytic activities given a UniProt accession identifier.","exampleAgentPrompt":"Look up the function, cellular locations, and catalytic activities for the protein with UniProt accession P04637 — also include the amino-acid sequence.","exampleUseCases":[{"title":"Drug target characterization","prompt":"What is the biological function, subcellular location, and catalytic activity of the protein with UniProt accession P00533? I'm evaluating it as a drug target."},{"title":"Literature review for a protein","prompt":"Can you pull all the literature citations and functional annotations for UniProt accession O60341 so I can start a literature review?"},{"title":"Enzyme activity identification","prompt":"I need to know the catalytic activities and the organism source for UniProt accession P12931 — and please include the amino-acid sequence as well."}],"resultDescription":"Returns structured data for the specified protein including its functional description, organism of origin, subcellular/cellular locations, catalytic activities, literature citation references, and optionally the full amino-acid sequence.","failureModes":["Invalid or non-existent UniProt accession returns an error or empty result","Accession for a protein not yet annotated in UniProt may return partial data","Network timeouts if UniProt upstream is slow","Malformed accession string (wrong format) may return a validation error"],"whenToPreferThis":"Use this endpoint when you need structured, curated protein annotations (function, localization, catalytic activity, citations) for a known UniProt accession. It is ideal for bioinformatics pipelines, drug target research, or any automated workflow that requires reliable, machine-readable protein metadata without scraping UniProt directly.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-10-29T07:19:26.234Z","isFirstParty":false,"canonicalSlug":"protein-function-lookup-by-uniprot-accession-219cac6b"}