{"uid":"cap_XgfxTD0VWgTeAS84vztVC","slug":"slicc-2012-sle-classifier-fd662dd0","name":"SLICC 2012 SLE Classifier","description":"SLICC 2012 SLE classification (Petri Table 3). classified iff biopsy-proven lupus nephritis plus ANA or anti-dsDNA, or at least four criteria including at least one clinical and one immunologic. 11 clinical and 6 immunologic caller flags. Direct Coombs counts only in the absence of hemolytic anemia. Criteria need not be concurrent. Not a diagnosis. Not 1997 ACR. Not 2019 EULAR/ACR. magent does not examine skin, assay serologies, or read a biopsy.","url":"https://api.magentlab.com/api/calc/slicc_sle","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["acute_cutaneous_lupus","chronic_cutaneous_lupus","oral_or_nasal_ulcers","nonscarring_alopecia","synovitis","serositis","renal","neurologic","hemolytic_anemia","leukopenia_or_lymphopenia","thrombocytopenia","ana","anti_dsdna","anti_sm","antiphospholipid","low_complement","direct_coombs","biopsy_lupus_nephritis"],"properties":{"ana":{"type":"boolean","description":"ANA above laboratory reference range as assigned by the caller (Petri 2012 Table 3). With biopsy_lupus_nephritis (or anti_dsdna), fulfills the nephritis shortcut. true or false. magent does not assay ANA."},"renal":{"type":"boolean","description":"Renal clinical criterion as assigned by the caller (Petri 2012 Table 3): urine protein-to-creatinine ratio (or 24-hour urine protein) representing 500 mg protein/24 hours, or red blood cell casts. Distinct from biopsy_lupus_nephritis. true or false. magent does not assay urine."},"anti_sm":{"type":"boolean","description":"Antibody to Sm nuclear antigen as assigned by the caller (Petri 2012 Table 3). true or false. magent does not assay anti-Sm."},"serositis":{"type":"boolean","description":"Serositis as assigned by the caller (Petri 2012 Table 3): typical pleurisy >1 day or pleural effusion or pleural rub, or typical pericardial pain >1 day or pericardial effusion or pericardial rub or pericarditis by electrocardiography, in the absence of other causes. true or false. magent does not examine the chest."},"synovitis":{"type":"boolean","description":"Synovitis involving 2 or more joints, characterized by swelling or effusion, or tenderness in 2 or more joints and at least 30 minutes of morning stiffness, as assigned by the caller (Petri 2012 Table 3). true or false. magent does not examine joints."},"anti_dsdna":{"type":"boolean","description":"Anti-dsDNA above laboratory reference range (or >2-fold the reference range if tested by ELISA), as assigned by the caller (Petri 2012 Table 3). true or false. magent does not assay anti-dsDNA."},"neurologic":{"type":"boolean","description":"Neurologic criterion as assigned by the caller (Petri 2012 Table 3): seizures, psychosis, mononeuritis multiplex, myelitis, peripheral or cranial neuropathy, or acute confusional state, in the absence of other known causes. true or false. magent does not examine the nervous system."},"direct_coombs":{"type":"boolean","description":"Direct Coombs’ test as assigned by the caller (Petri 2012 Table 3). Counts toward immunologic_count only when hemolytic_anemia is false. true or false. magent does not run a Coombs test."},"low_complement":{"type":"boolean","description":"Low C3, low C4, or low CH50 as assigned by the caller (Petri 2012 Table 3). true or false. magent does not assay complement."},"antiphospholipid":{"type":"boolean","description":"Antiphospholipid antibody positivity as assigned by the caller (Petri 2012 Table 3): lupus anticoagulant, false-positive rapid plasma reagin, medium- or high-titer anticardiolipin (IgA, IgG, or IgM), or anti-β2-glycoprotein I (IgA, IgG, or IgM). true or false. magent does not assay antiphospholipid antibodies."},"hemolytic_anemia":{"type":"boolean","description":"Hemolytic anemia as assigned by the caller (Petri 2012 Table 3). When true, direct_coombs does not count toward immunologic_count. true or false. magent does not assay hemolysis."},"thrombocytopenia":{"type":"boolean","description":"Thrombocytopenia (<100,000/mm³) at least once in the absence of other known causes, as assigned by the caller (Petri 2012 Table 3). true or false. magent does not assay platelets."},"nonscarring_alopecia":{"type":"boolean","description":"Nonscarring alopecia: diffuse thinning or hair fragility with visible broken hairs, in the absence of other causes, as assigned by the caller (Petri 2012 Table 3). true or false. magent does not examine the scalp."},"oral_or_nasal_ulcers":{"type":"boolean","description":"Oral ulcers (palate, buccal, tongue) or nasal ulcers, in the absence of other causes, as assigned by the caller (Petri 2012 Table 3). true or false. magent does not examine mucosa."},"acute_cutaneous_lupus":{"type":"boolean","description":"Acute cutaneous lupus as assigned by the caller (Petri 2012 Table 3): lupus malar rash (do not count if malar discoid), bullous lupus, toxic epidermal necrolysis variant of SLE, maculopapular lupus rash, photosensitive lupus rash in the absence of dermatomyositis, or subacute cutaneous lupus. true or false. magent does not examine skin."},"biopsy_lupus_nephritis":{"type":"boolean","description":"Biopsy-proven nephritis compatible with SLE as assigned by the caller (Petri 2012 classification rule). With ANA or anti-dsDNA, classifies without four criteria. Distinct from the renal clinical item. true or false. magent does not read a biopsy."},"chronic_cutaneous_lupus":{"type":"boolean","description":"Chronic cutaneous lupus as assigned by the caller (Petri 2012 Table 3): classic discoid (localized or generalized), hypertrophic (verrucous) lupus, lupus panniculitis (profundus), mucosal lupus, lupus erythematosus tumidus, chilblains lupus, or discoid lupus/lichen planus overlap. true or false. magent does not examine skin."},"leukopenia_or_lymphopenia":{"type":"boolean","description":"Leukopenia (<4,000/mm³ at least once) in the absence of other known causes, or lymphopenia (<1,000/mm³ at least once) in the absence of other known causes, as assigned by the caller (Petri 2012 Table 3). true or false. magent does not assay blood counts."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_P4P0AFxt3ILuHH-gU4BiX","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Applies the SLICC 2012 classification criteria to determine if a patient meets the definition of systemic lupus erythematosus (SLE), including the biopsy-proven lupus nephritis shortcut.","exampleAgentPrompt":"Apply the SLICC 2012 SLE classification to my patient: they have synovitis, serositis, and nonscarring alopecia as clinical findings, and ANA and low complement as immunologic findings — no biopsy-proven lupus nephritis, no hemolytic anemia, no direct Coombs issue. Do they meet SLICC 2012 criteria?","exampleUseCases":[{"title":"Lupus nephritis shortcut classification","prompt":"My patient has a biopsy-proven lupus nephritis and a positive ANA — does that satisfy the SLICC 2012 classification shortcut for SLE? All other flags are false."},{"title":"Four-criterion minimum rule check","prompt":"Check SLICC 2012 for a patient with acute cutaneous lupus, synovitis, anti-dsDNA positive, and low complement — no other criteria positive, no biopsy nephritis. Do they meet the four-criterion rule with at least one clinical and one immunologic?"},{"title":"Complex multisystem SLE workup","prompt":"Run SLICC 2012 classification on a patient who has chronic cutaneous lupus, oral ulcers, thrombocytopenia, leukopenia, anti-Sm positive, antiphospholipid antibodies, and low complement — no hemolytic anemia so direct Coombs is relevant and is positive, no biopsy nephritis. Does this patient classify as SLE?"}],"resultDescription":"A structured result indicating whether the patient meets the SLICC 2012 SLE classification criteria, including whether the biopsy-proven lupus nephritis shortcut was triggered, how many clinical and immunologic criteria were satisfied, and whether the minimum four-criterion threshold (with at least one clinical and one immunologic) was reached. This is a classification output, not a clinical diagnosis.","failureModes":["Missing required query parameters (all 18 Boolean flags are required) returns a validation error","Passing non-Boolean values for flag parameters causes a schema error","Misinterpreting the direct Coombs flag: it only counts in the absence of hemolytic anemia — the caller must enforce this logic before passing values","Confusing the renal clinical criterion with biopsy_lupus_nephritis — these are distinct parameters","Expecting the API to perform lab assays, physical examination, or biopsy reading — it only scores caller-supplied flags"],"whenToPreferThis":"Use this endpoint when you need to apply the specific SLICC 2012 (Petri Table 3) classification framework for SLE — not the 1997 ACR criteria and not the 2019 EULAR/ACR criteria. Ideal for clinical decision support pipelines, research cohort screening, or EHR-integrated tools where clinical and immunologic assessments have already been made by a clinician and need to be scored automatically. Do not use if you need the 1997 ACR or 2019 EULAR/ACR classification.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-15T07:14:15.031Z","isFirstParty":false}