{"uid":"cap_X4NxTc9KvibyhQpYKM6tx","slug":"magent-mcdonald-2024-ms-criteria-calculator-6fac1465","name":"magent McDonald 2024 MS Criteria Calculator","description":"2024 McDonald typical CIS (Montalban 2025). mcdonald_ms iff typical_cis and no_better_explanation and: ≥2 attacks with ≥2 lesions; or ≥2 attacks with one lesion plus DIS; or CIS with ≥2 lesions plus MRI DIT, OCB, or kappa FLC; or CIS with one lesion plus DIS and MRI DIT, OCB, or kappa FLC. DIS = ≥2 of 5 topographies (optic nerve added). Kappa FLC interchangeable with OCB. Not 2017 McDonald. Not PPMS. Not RIS. magent does not read MRI or assay CSF. Not a diagnosis. Not a medical device.","url":"https://api.magentlab.com/api/calc/mcdonald_2024","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["typical_cis","no_better_explanation","two_or_more_attacks","two_or_more_lesions","periventricular","cortical_or_juxtacortical","infratentorial","spinal_cord","optic_nerve","dit_mri","csf_specific_ocb","csf_kflc"],"properties":{"dit_mri":{"type":"boolean","description":"MRI dissemination in time as assigned by the caller (simultaneous Gd-enhancing and non-enhancing lesions, or a new T2 or Gd-enhancing lesion on follow-up vs baseline). true or false. magent does not read MRI."},"csf_kflc":{"type":"boolean","description":"CSF kappa free-light chains positive as assigned by the caller (2024: interchangeable with oligoclonal bands as the CSF DIT marker). Caller-assigned flag only; this tool does not apply a numeric kFLC index cutoff. true or false. magent does not assay CSF."},"optic_nerve":{"type":"boolean","description":"Caller-assigned typical optic-nerve topography (fifth 2024 DIS location; Montalban 2025). true or false. magent does not read MRI, OCT, or VEP."},"spinal_cord":{"type":"boolean","description":"Caller-assigned typical spinal-cord MS lesion topography (one of five 2024 DIS locations). true or false. magent does not read MRI."},"typical_cis":{"type":"boolean","description":"Typical clinically isolated syndrome as assigned by the caller (Montalban 2025 typical CIS / relapsing pathway). If false, mcdonald_ms is false; this tool does not diagnose MS from atypical presentations, PPMS, or RIS. true or false. magent does not examine the patient."},"infratentorial":{"type":"boolean","description":"Caller-assigned typical infratentorial MS lesion topography (one of five 2024 DIS locations). true or false. magent does not read MRI."},"periventricular":{"type":"boolean","description":"Caller-assigned typical periventricular MS lesion topography (one of five 2024 DIS locations). true or false. magent does not read MRI."},"csf_specific_ocb":{"type":"boolean","description":"CSF-specific oligoclonal bands as assigned by the caller (2024 DIT substitute; interchangeable with kappa free-light chains). true or false. magent does not assay CSF."},"two_or_more_attacks":{"type":"boolean","description":"≥2 clinical attacks as assigned by the caller. true means two or more attacks; false means this is the first/CIS attack. true or false. magent does not date attacks."},"two_or_more_lesions":{"type":"boolean","description":"Objective clinical evidence of ≥2 lesions as assigned by the caller. true means ≥2 lesions; false means 1 lesion. true or false. magent does not examine the patient."},"no_better_explanation":{"type":"boolean","description":"No better explanation for the presentation as assigned by the caller (Montalban 2025). If false, mcdonald_ms is false. Remain vigilant for NMOSD. true or false. magent does not assign a better explanation."},"cortical_or_juxtacortical":{"type":"boolean","description":"Caller-assigned typical cortical or juxtacortical MS lesion topography (one of five 2024 DIS locations). true or false. magent does not read MRI."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_jXPnYISkNBPf-w92MMP4W","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Evaluates 2024 McDonald criteria for relapsing-onset multiple sclerosis diagnosis based on caller-assigned clinical and paraclinical inputs","exampleAgentPrompt":"Apply the 2024 McDonald criteria for this patient: typical CIS, no better explanation, one attack, one lesion, DIS met (periventricular and spinal cord positive, optic nerve positive), MRI DIT positive, OCB positive — does this patient meet McDonald 2024 MS criteria?","exampleUseCases":[{"title":"CIS with MRI findings MS check","prompt":"I have a patient with a typical clinically isolated syndrome, no better explanation, one attack, one lesion, but MRI shows dissemination in space (periventricular and cortical lesions positive) and dissemination in time, and CSF OCB is positive. Does this meet 2024 McDonald criteria for MS?"},{"title":"Two attacks two lesions MS evaluation","prompt":"Check McDonald 2024 criteria for a patient with typical CIS, no better explanation, two or more attacks, two or more lesions, no MRI DIT, no OCB, no kappa free-light chains — periventricular and spinal cord topographies are positive. Does this patient qualify?"},{"title":"Optic neuritis plus spinal cord lesion DIS check","prompt":"For a patient with typical CIS and no better explanation, one attack, one lesion, optic nerve topography positive and spinal cord topography positive but no other DIS locations, MRI DIT is positive, kappa free-light chains positive, no OCB — run the 2024 McDonald MS criteria check."}],"resultDescription":"Returns a boolean indicating whether the 2024 McDonald criteria for relapsing-onset MS are met, along with intermediate flags for dissemination in space (DIS) and dissemination in time (DIT) satisfaction, based entirely on caller-assigned inputs. Does not perform MRI reading, CSF assay, or patient examination.","failureModes":["Missing required query parameters returns a validation error","Incorrect boolean string formats may cause parsing failure","Endpoint does not handle PPMS, RIS, or atypical CIS — always returns false for non-typical CIS","Caller-assigned inputs that contradict clinical reality are not validated by the API","Network timeout or 402 payment failure if USDC payment header is missing or insufficient"],"whenToPreferThis":"Choose this endpoint when you need a deterministic, formula-based evaluation of the published 2024 McDonald MS diagnostic criteria (Montalban 2025 update) for a relapsing-onset pathway, especially when optic nerve as a fifth DIS topography or kappa free-light chains as a DIT marker are relevant. Prefer over manual calculation when integrating into clinical decision support pipelines requiring reproducible, auditable outputs. Not suitable for PPMS, RIS, atypical presentations, or when MRI reading or CSF assay is needed.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T13:03:20.142Z","isFirstParty":false}