{"uid":"cap_T_tHMAx8eR_JdKCwXuAjZ","slug":"cll-ipi-2016-calculator-436ed1a8","name":"CLL-IPI 2016 Calculator","description":"CLL-IPI 2016 for chronic lymphocytic leukaemia: TP53 abnormality (del(17p) and/or TP53 mutation) 4, unmutated IGHV 2, beta-2 microglobulin >3.5 mg/L 2, advanced stage (Binet B/C or Rai I–IV) 1, age >65 1; max 10. Low 0–1, intermediate 2–3, high 4–6, very_high 7–10. Deterministic published score with citation; not a CLL diagnosis; not Shipp IPI; not MIPI. magent does not assay TP53, IGHV, or beta-2 microglobulin.","url":"https://api.magentlab.com/api/calc/cll_ipi","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["tp53_abnormal","ighv_unmutated","beta2_microglobulin_mg_l","advanced_stage","age"],"properties":{"age":{"type":"integer","description":"Age in years (18-120). Age >65 scores 1 (CLL-IPI 2016). Age 65 is the ≤65 arm and scores 0."},"tp53_abnormal":{"type":"boolean","description":"del(17p) and/or TP53 mutation as assigned by the caller (CLL-IPI 2016). true scores 4. magent does not assay TP53."},"advanced_stage":{"type":"boolean","description":"Binet B/C or Rai I–IV as assigned by the caller (CLL-IPI 2016). true scores 1. false is Binet A / Rai 0. magent does not stage CLL."},"ighv_unmutated":{"type":"boolean","description":"Unmutated IGHV as assigned by the caller (CLL-IPI 2016). true scores 2. magent does not sequence IGHV."},"beta2_microglobulin_mg_l":{"type":"number","description":"Serum beta-2 microglobulin in mg/L (0.2-40). >3.5 scores 2 (CLL-IPI 2016). 3.5 is the ≤3.5 arm and scores 0. magent does not assay beta-2 microglobulin."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_beyRZHS_hPFY9n2j5tS0n","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the CLL-IPI 2016 prognostic score for chronic lymphocytic leukaemia, categorizing risk as low, intermediate, high, or very high based on five clinical parameters.","exampleAgentPrompt":"Calculate the CLL-IPI 2016 score for a 68-year-old patient who has a TP53 deletion, unmutated IGHV, serum beta-2 microglobulin of 4.2 mg/L, and is Binet stage B — what is their risk category?","exampleUseCases":[{"title":"Prognosis stratification at CLL diagnosis","prompt":"My patient is 72 years old, has a confirmed TP53 mutation, unmutated IGHV, beta-2 microglobulin of 5.1 mg/L, and is Rai stage II — can you run the CLL-IPI 2016 and tell me their risk group?"},{"title":"Clinical trial eligibility risk screening","prompt":"For a 60-year-old CLL patient with no TP53 abnormality, mutated IGHV, beta-2 microglobulin of 2.8 mg/L, and Binet A stage, what does the CLL-IPI 2016 score come out to?"},{"title":"Longitudinal risk re-assessment after restaging","prompt":"After restaging, my 67-year-old CLL patient now has advanced disease (Binet C), TP53 deletion detected, IGHV unmutated, and beta-2 microglobulin of 3.9 mg/L — recalculate their CLL-IPI score and risk category."}],"resultDescription":"Returns the numeric CLL-IPI total score (0–10) and a categorical risk label — low (0–1), intermediate (2–3), high (4–6), or very_high (7–10) — based on the 2016 published algorithm and component point contributions.","failureModes":["Missing required parameters (tp53_abnormal, ighv_unmutated, beta2_microglobulin_mg_l, advanced_stage, age) returns a validation error","beta2_microglobulin_mg_l outside range 0.2–40 may be rejected or flagged","age outside range 18–120 returns a validation error","Payment failure (insufficient USDC balance or missing x402 header) blocks the request","Caller supplying biologically inconsistent inputs (e.g. negative beta-2 microglobulin) will receive an error"],"whenToPreferThis":"Use this endpoint when you need a deterministic, citation-backed CLL-IPI 2016 score computation and already have the five required clinical values (TP53 status, IGHV mutation status, beta-2 microglobulin level, clinical stage, patient age) pre-assayed. Prefer this over building your own scoring logic to ensure alignment with the published 2016 algorithm. This is not a diagnostic tool for CLL, does not perform any laboratory assays, and is not appropriate for Shipp IPI, MIPI, or other lymphoma prognostic indices.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-13T18:55:26.428Z","isFirstParty":false}