{"uid":"cap_QbzorZpT6I0yI7bo77SSN","slug":"grogan-2016-attrwt-cardiac-staging-calculator-f9dffaec","name":"Grogan 2016 ATTRwt Cardiac Staging Calculator","description":"Grogan 2016 ATTRwt staging: 1 point when NT-proBNP >3000 ng/L; 1 point when cardiac TnT >0.05 ng/mL. Stage I = 0, II = 1, III = 2. Equal to a cutoff does not score. Cohort 4-year OS I 57% / II 42% / III 18%; stage III median 20 months (labels, not a prediction). Troponin T only. Not Gillmore NAC (no eGFR). Not Mayo AL. Not NYHA. magent does not assay the biomarkers.","url":"https://api.magentlab.com/api/calc/grogan","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["nt_probnp_ng_l","troponin_t_ng_ml"],"properties":{"nt_probnp_ng_l":{"type":"number","description":"NT-proBNP in ng/L (10-100000), same numeric value as pg/mL. Grogan 2016 scores 1 point when > 3000; equal to 3000 does not score. magent does not assay NT-proBNP."},"troponin_t_ng_ml":{"type":"number","description":"Cardiac troponin T (cTnT) in ng/mL (0.001-50), same numeric value as 0.05 μg/L. Grogan 2016 scores 1 point when > 0.05; equal to 0.05 does not score. Troponin T only; magent does not invent a troponin I cutoff and does not assay troponin."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_5YZv3Oftk5ed_0X2nrvz_","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Calculates the Grogan 2016 staging score for wild-type transthyretin amyloid cardiomyopathy (ATTRwt) using NT-proBNP and cardiac troponin T values","exampleAgentPrompt":"Using the Grogan 2016 ATTRwt staging system, what stage is a patient with NT-proBNP of 4200 ng/L and cardiac troponin T of 0.07 ng/mL?","exampleUseCases":[{"title":"ATTRwt staging for cardiology consult","prompt":"I have a patient with wild-type ATTR cardiomyopathy — NT-proBNP is 3500 ng/L and cardiac troponin T is 0.04 ng/mL. What's their Grogan 2016 stage?"},{"title":"Prognosis discussion with patient family","prompt":"Our patient's labs show NT-proBNP at 1800 ng/L and troponin T at 0.06 ng/mL. Can you calculate their ATTRwt Grogan stage and tell me the associated cohort survival data?"},{"title":"Automated EHR biomarker staging pipeline","prompt":"Given NT-proBNP 3100 ng/L and cardiac troponin T 0.09 ng/mL, calculate the Grogan 2016 ATTRwt staging score and return the stage number."}],"resultDescription":"Returns the Grogan 2016 ATTRwt stage (I, II, or III) based on the computed score (0, 1, or 2 points), with reference cohort 4-year overall survival rates: Stage I ~57%, Stage II ~42%, Stage III ~18% (median 20 months for Stage III). These are historical cohort labels, not individual predictions.","failureModes":["Missing required query parameters (nt_probnp_ng_l or troponin_t_ng_ml) returns a validation error","Values outside accepted ranges (NT-proBNP: 10–100000 ng/L; troponin T: 0.001–50 ng/mL) may be rejected","Troponin I values provided instead of troponin T — endpoint only accepts troponin T and will not substitute","Payment not provided or invalid x402 payment header results in 402 Payment Required"],"whenToPreferThis":"Use this endpoint when you need to apply the Grogan 2016 ATTRwt cardiac staging schema specifically — it uses only NT-proBNP and cardiac troponin T (not eGFR, troponin I, BNP, or NYHA class). Prefer this over Mayo AL staging (which is for AL amyloid), Gillmore NAC staging (which requires eGFR), and NYHA functional class. Suitable for automating staging in clinical workflows where biomarker values are already available.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T07:08:38.003Z","isFirstParty":false}