{"uid":"cap_NUyWFJntK4aC5HfLDMSGp","slug":"mars-mutation-adjusted-risk-score-for-advanced-systemic-mastocytosis-bef1d777","name":"MARS (Mutation-Adjusted Risk Score) for Advanced Systemic Mastocytosis","description":"Jawhar 2019 mutation-adjusted risk score (MARS) for advanced systemic mastocytosis: age >60 (1), hemoglobin <10 g/dL (1), platelets <100×10^9/L (1), exactly one S/A/R mutation among SRSF2, ASXL1, RUNX1 (1) or two or more (2, not both). Max 5. Low 0–1 (training-set median OS not reached), intermediate 2 (3.9 y), high 3–5 (1.9 y). Not WHO SM criteria. magent does not sequence or assay labs.","url":"https://api.magentlab.com/api/calc/mars","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["age","platelets_10e9_l","sar_mutation_count"],"properties":{"age":{"type":"integer","description":"Age in years (integer 18-120). >60 scores 1 (Jawhar 2019). Age 61 scores; age 60 is the ≤60 arm and scores 0."},"hemoglobin_g_l":{"type":"number","description":"Hemoglobin in g/L (30-220). Converted as hemoglobin_g_dl = hemoglobin_g_l / 10. Provide this or hemoglobin_g_dl, not both. <100 g/L scores 1. 100 is the ≥100 arm and scores 0."},"hemoglobin_g_dl":{"type":"number","description":"Hemoglobin in g/dL (3-22). Provide this or hemoglobin_g_l, not both. <10 g/dL (<100 g/L) scores 1 (Jawhar 2019). 10.0 is the ≥10 arm and scores 0. magent does not assay hemoglobin."},"platelets_10e9_l":{"type":"number","description":"Platelet count in 10^9/L (1-2000). <100 scores 1 (Jawhar 2019). 100.0 is the ≥100 arm and scores 0. magent does not assay platelets."},"sar_mutation_count":{"type":"integer","description":"Caller-assigned count of S/A/R mutations among SRSF2, ASXL1, and RUNX1 (integer 0, 1, or 2; 2 means two or more). Exactly one scores 1. Two or more scores 2 (not 1 plus 2). Count 0 scores 0. magent does not sequence."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_8McEOaV89z8zZBJVmaSyj","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the Jawhar 2019 MARS prognostic integer score (0–5) for advanced systemic mastocytosis and returns OS-based risk tier (low/intermediate/high).","exampleAgentPrompt":"Calculate the Jawhar 2019 MARS score for an advanced systemic mastocytosis patient who is 67 years old, has hemoglobin of 8.5 g/dL, platelets of 75 × 10^9/L, and exactly one S/A/R mutation (ASXL1 positive).","exampleUseCases":[{"title":"Hematologist prognostic risk assessment","prompt":"My advanced SM patient is 72 years old, hemoglobin 9.2 g/dL, platelets 60 × 10^9/L, and has two S/A/R mutations (SRSF2 and ASXL1). What is their MARS score and risk tier?"},{"title":"Treatment planning for intermediate-risk ASM","prompt":"I need to stratify a 58-year-old advanced systemic mastocytosis patient: hemoglobin is 11 g/dL, platelets are 95 × 10^9/L, and they have one SAR mutation (RUNX1). What MARS score do they get and what does that mean for survival?"},{"title":"Clinical trial eligibility screening","prompt":"Screen this ASM patient for our high-risk trial arm — they're 65 years old, hemoglobin 8.0 g/dL, platelets 45 × 10^9/L, zero S/A/R mutations. Run the Jawhar MARS calculation and tell me if they fall into the high-risk group."}],"resultDescription":"Returns the MARS integer total score (0–5), each component's contribution, and the corresponding risk tier: low (0–1, median OS not reached in training set), intermediate (2, ~3.9 years median OS), or high (3–5, ~1.9 years median OS). Does not perform lab assays or genetic sequencing — caller supplies all values.","failureModes":["Missing required parameter (age, platelets_10e9_l, or sar_mutation_count) returns a validation error","Both hemoglobin_g_l and hemoglobin_g_dl provided simultaneously triggers a conflict error","sar_mutation_count outside 0–2 range returns a validation error","Age outside 18–120 or platelets outside 1–2000 returns out-of-range validation error","Boundary values (age=60, platelets=100, hemoglobin=10) score 0 per published ≤60 / ≥100 / ≥10 arm definitions"],"whenToPreferThis":"Use when you need to apply the Jawhar 2019 MARS algorithm specifically for advanced systemic mastocytosis (ASM) prognostication; this is the validated integer model incorporating S/A/R mutation burden alongside CBC parameters and age. Prefer over generic oncology risk tools when the patient has confirmed ASM and caller-assigned SRSF2/ASXL1/RUNX1 mutation status is available.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-15T01:21:01.542Z","isFirstParty":false}