{"uid":"cap_M02njchKB5_pvWer6mfmm","slug":"dutch-lipid-clinic-network-dlcn-familial-hypercholesterolaemia-score-f04bed09","name":"Dutch Lipid Clinic Network (DLCN) Familial Hypercholesterolaemia Score","description":"Dutch Lipid Clinic Network (Nordestgaard 2013 Table 1) familial hypercholesterolaemia score. One LDL (mmol/L or mg/dL / 38.67) plus family, clinical, physical, and DNA groups; per group only the highest. Max 26. Definite >8, probable 6-8, possible 3-5, unlikely 0-2. Score 8 (mutation alone) is probable. Adult Table 1 only; not Simon Broome, not MEDPED, not homozygous FH. magent does not assay lipids, examine tendons or arcus, or sequence genes. Not a medical device and not a diagnosis of FH.","url":"https://api.magentlab.com/api/calc/dutch_fh","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["first_degree_premature_chd","first_degree_ldl_gt_95th","first_degree_xanthoma_or_arcus","child_ldl_gt_95th","premature_chd","premature_cerebral_or_pvd","tendon_xanthoma","corneal_arcus_age_lt_45","causative_mutation_ldlr_apob_pcsk9"],"properties":{"ldl_mg_dl":{"type":"number","description":"LDL cholesterol in mg/dL (40-800). Converted to mmol/L as mg/dL / 38.67, then scored on the mmol/L bands. Provide exactly one lipid parameter."},"ldl_mmol_l":{"type":"number","description":"LDL cholesterol in mmol/L (1-20). Nordestgaard 2013 Table 1 bands: >8.5 → 8, 6.5-8.4 → 5, 5.0-6.4 → 3, 4.0-4.9 → 1. Provide exactly one of ldl_mmol_l or ldl_mg_dl. magent does not assay lipids."},"premature_chd":{"type":"boolean","description":"Premature coronary heart disease in the subject (Nordestgaard 2013 Table 1 clinical history, 2 points; men <55 years / women <60 years as assigned by the caller). true or false. magent does not diagnose CHD or compute age or sex. If premature_cerebral_or_pvd is also true, the clinical group is 2, not 3."},"tendon_xanthoma":{"type":"boolean","description":"Tendon xanthoma in the subject (Nordestgaard 2013 Table 1 physical examination, 6 points). true or false as assigned by the caller. magent does not examine tendons. If corneal_arcus_age_lt_45 is also true, the physical group is 6, not 10."},"child_ldl_gt_95th":{"type":"boolean","description":"Child under 18 years with LDL cholesterol above the 95th percentile (Nordestgaard 2013 Table 1 family history, 2 points). true or false as assigned by the caller. magent does not assay lipids or take a pedigree."},"corneal_arcus_age_lt_45":{"type":"boolean","description":"Arcus cornealis before age 45 years (Nordestgaard 2013 Table 1 physical examination, 4 points). true or false as assigned by the caller. magent does not examine the cornea or compute age."},"first_degree_ldl_gt_95th":{"type":"boolean","description":"First-degree relative with LDL cholesterol above the 95th percentile (Nordestgaard 2013 Table 1 family history, 1 point). true or false as assigned by the caller. magent does not assay lipids or take a pedigree."},"premature_cerebral_or_pvd":{"type":"boolean","description":"Premature cerebral or peripheral vascular disease in the subject (Nordestgaard 2013 Table 1 clinical history, 1 point). true or false as assigned by the caller. magent does not diagnose vascular disease."},"first_degree_premature_chd":{"type":"boolean","description":"First-degree relative with premature coronary heart disease (Nordestgaard 2013 Table 1 family history, 1 point). true or false as assigned by the caller. magent does not take a pedigree. Either this or first_degree_ldl_gt_95th scores 1 for the family group; a 2-point family item still yields family 2, not 3."},"first_degree_xanthoma_or_arcus":{"type":"boolean","description":"First-degree relative with tendon xanthoma and/or arcus cornealis (Nordestgaard 2013 Table 1 family history, 2 points). true or false as assigned by the caller. magent does not examine relatives. Either this or child_ldl_gt_95th scores 2 for the family group (max of family items)."},"causative_mutation_ldlr_apob_pcsk9":{"type":"boolean","description":"Causative mutation in LDLR, APOB, or PCSK9 as assigned by the caller (Nordestgaard 2013 Table 1 DNA analysis, 8 points). true or false. magent does not sequence genes. Mutation alone is probable (score 8), not definite."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_-4nZFadRD_iM8sn098lZA","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Calculates the Dutch Lipid Clinic Network (Nordestgaard 2013 Table 1) FH score from LDL cholesterol, family history, clinical history, physical findings, and DNA mutation status.","exampleAgentPrompt":"Calculate the Dutch Lipid Clinic Network FH score for a patient with an LDL of 5.8 mmol/L, premature coronary heart disease, a first-degree relative with premature CHD, no tendon xanthoma, no corneal arcus, no child with elevated LDL, no first-degree relative with LDL above the 95th percentile, no first-degree relative with xanthoma or arcus, and a confirmed causative LDLR mutation.","exampleUseCases":[{"title":"Lipid clinic FH triage","prompt":"I have a patient with LDL of 6.9 mmol/L, a father who had a heart attack at age 48, no tendon xanthomas, no corneal arcus, no children with high LDL, and no genetic test results yet — what is their Dutch FH score and how likely is familial hypercholesterolaemia?"},{"title":"Post-genetic-test FH classification","prompt":"A patient just got back a confirmed LDLR pathogenic variant. Their LDL is 5.2 mmol/L, they have no premature CHD themselves, no cerebral or peripheral vascular disease, no tendon xanthoma, no corneal arcus before 45, no relevant first-degree family history beyond the mutation. Run the DLCN score."},{"title":"EHR automation FH flagging","prompt":"For this patient record — LDL 220 mg/dL, premature CHD present, a first-degree relative with LDL above the 95th percentile, no xanthoma, no arcus, no child with high LDL, no known DNA mutation — compute the Dutch Lipid Clinic Network familial hypercholesterolaemia score."}],"resultDescription":"Returns the total DLCN FH score (0–26) broken down by group (lipid, family, clinical, physical, DNA), with per-group highest-item selection applied, plus a categorical FH probability label: definite (>8), probable (6–8), possible (3–5), or unlikely (0–2).","failureModes":["Missing required boolean flags returns a validation error","Supplying both ldl_mmol_l and ldl_mg_dl simultaneously returns an error (exactly one must be provided)","LDL value outside accepted range (mmol/L 1–20 or mg/dL 40–800) may be rejected or return an unexpected score","Misclassified caller-assigned clinical findings (e.g., incorrect age cutoffs for premature CHD) produce an incorrect score — garbage-in-garbage-out with no server-side guard","HTTP 402 returned if payment credentials are missing or invalid"],"whenToPreferThis":"Use this endpoint when you need to programmatically apply the adult Dutch Lipid Clinic Network (Nordestgaard 2013 Table 1) FH scoring algorithm — not the Simon Broome, MEDPED, or homozygous FH criteria — and all clinical findings have already been assessed by a clinician or extracted from structured EHR data. Ideal for automating lipid clinic workflows, EHR decision-support, or risk-stratification pipelines where LDL and family/clinical/DNA flags are available as structured inputs.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T19:09:07.058Z","isFirstParty":false}