{"uid":"cap_LZotXTPFBXWFsn6BtHbf0","slug":"ncbi-clinvar-genetic-variants-by-gene-symbol-fc78527a","name":"NCBI ClinVar Genetic Variants by Gene Symbol","description":"NCBI ClinVar variants for a human gene symbol: VCV accession, variant type, germline clinical significance (e.g. Pathogenic, Likely pathogenic) and last evaluation date. Up to 10 variants per call. Variant names and protein changes are not included.","url":"https://api.healthtravel-api.workers.dev/api/health/clinvar-genetic-variants?utm_source=zero.xyz","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET"],"type":"string"},"queryParams":{"type":"object","required":["gene"],"properties":{"max":{"type":"string","description":"How many variants, 1 to 10 (default 5)"},"gene":{"type":"string","description":"Human gene symbol, letters, digits and hyphens, 2 to 20 characters"}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.002","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.002/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.002","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.002","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_ersMyhqpHeNtC5RhSFT0s","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.002","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Fetches up to 10 ClinVar variant records (VCV accession, variant type, germline clinical significance, last evaluation date) for a given human gene symbol from NCBI ClinVar.","exampleAgentPrompt":"Can you pull up the ClinVar variants for the BRCA1 gene — show me up to 8, including their VCV accessions, variant types, germline clinical significance, and last evaluation dates?","exampleUseCases":[{"title":"Pathogenic variant research for BRCA2","prompt":"Look up the top 10 ClinVar germline variants for the BRCA2 gene and tell me which ones are classified as Pathogenic or Likely Pathogenic, along with their VCV accessions and when they were last evaluated."},{"title":"Clinical significance screening for Lynch syndrome gene","prompt":"Can you fetch ClinVar variants for the MLH1 gene — I need to know the variant types and their germline clinical significance classifications for a report on Lynch syndrome risk."},{"title":"ClinVar evaluation recency check for PTEN","prompt":"Get me up to 5 ClinVar variants for the PTEN gene and tell me the most recent evaluation dates — I want to know how current the data is for each one."}],"resultDescription":"Returns a list of up to 10 ClinVar variant records for the specified gene, each containing: VCV accession number, variant type (e.g. single nucleotide variant, deletion), germline clinical significance (e.g. Pathogenic, Likely Pathogenic, Uncertain Significance), and last evaluation date. Variant names and protein changes are not included.","failureModes":["Invalid or unrecognized gene symbol returns empty results or an error","max parameter out of range (not 1–10) may return an error or be clamped to defaults","Gene symbol with no ClinVar entries returns an empty list","Rate limiting or upstream NCBI ClinVar API unavailability may cause timeout or error responses","Genes with very large numbers of variants may only return a partial subset up to the configured max"],"whenToPreferThis":"Use this endpoint when you need structured ClinVar germline clinical significance data (Pathogenic, Likely Pathogenic, etc.) quickly for a specific human gene symbol, without needing full variant names or protein-level details. Prefer this over direct NCBI API calls when you need a simple, pay-per-call interface returning up to 10 variants. Not suitable if you need protein change annotations, variant names, or somatic variants.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-10-29T00:33:26.997Z","isFirstParty":false,"canonicalSlug":"ncbi-clinvar-genetic-variants-by-gene-symbol-fc78527a"}