{"uid":"cap_JZqC5mJav9P-_JRdMK4W-","slug":"dipss-calculator-for-primary-myelofibrosis-passamonti-2010-562fb24a","name":"DIPSS Calculator for Primary Myelofibrosis (Passamonti 2010)","description":"Passamonti 2010 DIPSS for primary myelofibrosis: age >65 (1), WBC >25×10^9/L (1), hemoglobin <10 g/dL (2), peripheral-blood blasts ≥1% (1), constitutional symptoms (1); max 6. Low 0, intermediate_1 1–2, intermediate_2 3–4, high 5–6. Not DIPSS Plus or aaDIPSS. magent does not read a smear; constitutional symptoms are caller-assigned.","url":"https://api.magentlab.com/api/calc/dipss","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["age","hemoglobin_g_dl","wbc_10e9_l","blasts_percent","constitutional_symptoms"],"properties":{"age":{"type":"integer","description":"Age in years (18-120). Age >65 scores 1 (Passamonti 2010 Table 3). Age 65 is the ≤65 arm and scores 0."},"wbc_10e9_l":{"type":"number","description":"White-cell count in 10^9/L (0.1-500). >25 scores 1 (Passamonti 2010 Table 3). 25.0 is the ≤25 arm and scores 0. magent does not assay WBC."},"blasts_percent":{"type":"number","description":"Peripheral-blood blasts as a percent (0-30). ≥1 scores 1 (Passamonti 2010 Table 3). 0.9 is the <1 arm and scores 0. magent does not read a smear."},"hemoglobin_g_dl":{"type":"number","description":"Hemoglobin in g/dL (3-20). <10 scores 2 (Passamonti 2010 Table 3; anemia HR 4.18). 10.0 is the ≥10 arm and scores 0. magent does not assay hemoglobin."},"constitutional_symptoms":{"type":"boolean","description":"Weight loss >10% in 6 months, night sweats, or unexplained fever >37.5°C as assigned by the caller (Passamonti 2010 methods). true scores 1. magent does not take a history."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_ZELmjWNM9HVNqW_ZaK6L1","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the Dynamic International Prognostic Scoring System (DIPSS) risk score and category for primary myelofibrosis using five clinical variables from Passamonti 2010","exampleAgentPrompt":"Calculate the DIPSS score for a 70-year-old PMF patient with WBC 30×10^9/L, hemoglobin 9.2 g/dL, peripheral-blood blasts at 2%, and constitutional symptoms present — what's their risk category?","exampleUseCases":[{"title":"Hematology consult risk stratification","prompt":"I'm seeing a 68-year-old primary myelofibrosis patient: WBC is 28×10^9/L, hemoglobin 8.5 g/dL, blasts at 1.5%, and she has night sweats and weight loss. What does the DIPSS score come out to and what risk category is she?"},{"title":"Pre-transplant prognostic triage","prompt":"Before referring this 72-year-old PMF patient for stem cell transplant evaluation, I need to know his DIPSS score — WBC 22×10^9/L, hemoglobin 11 g/dL, blasts 0%, no constitutional symptoms. What risk tier is he?"},{"title":"Automated EHR prognostic flag","prompt":"Run the Passamonti DIPSS calculator for this patient: age 60, WBC 14×10^9/L, hemoglobin 10.5 g/dL, peripheral blasts 0.5%, no constitutional symptoms — is this low or intermediate risk?"}],"resultDescription":"Returns a JSON object with the computed DIPSS total score (integer 0–6) and a risk category label: Low (0 points), Intermediate-1 (1–2 points), Intermediate-2 (3–4 points), or High (5–6 points), based on the Passamonti 2010 scoring table.","failureModes":["Missing required query parameters (age, hemoglobin_g_dl, wbc_10e9_l, blasts_percent, constitutional_symptoms) returns a validation error","Age outside 18–120, hemoglobin outside 3–20, WBC outside 0.1–500, or blasts outside 0–30 may return a 422 or similar validation error","Boundary values (age exactly 65, WBC exactly 25, hemoglobin exactly 10, blasts exactly 0.9) score 0 per the ≤ arm as documented","Constitutional symptoms must be boolean true/false — string values or missing field will cause an error","Payment failure (x402) if USDC balance or HTTP 402 flow is not handled by the client"],"whenToPreferThis":"Use this endpoint when you need to calculate the original Passamonti 2010 DIPSS score specifically — not DIPSS Plus (which adds karyotype, transfusion dependence, and platelet count) and not aaDIPSS. Prefer this when working with the standard five-variable prognostic model for primary myelofibrosis, or when you need a validated, reproducible numeric score for clinical documentation, research, or triage workflows.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-16T00:55:58.781Z","isFirstParty":false}