{"uid":"cap_I6UVLSFBAjLWCHMcRrsMn","slug":"who-2016-polycythemia-vera-diagnostic-criteria-calculator-arber-2016-de7f37a3","name":"WHO 2016 Polycythemia Vera Diagnostic Criteria Calculator (Arber 2016)","description":"WHO 2016 polycythemia vera criteria (Arber 2016). Met when all three majors hold, or when major 1 and major 2 hold with subnormal EPO. Major 1 is male Hb >16.5 g/dL or Hct >49%, female Hb >16.0 or Hct >48%, or increased red-cell mass. Major 2 is caller-assigned marrow panmyelosis. Major 3 is JAK2 V617F or exon 12. Not a medical device, not a WHO diagnosis, and not WHO 2022. magent does not assay EPO or sequence JAK2.","url":"https://api.magentlab.com/api/calc/who_pv","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["sex","increased_red_cell_mass","bone_marrow_panmyelosis","jak2_v617f_or_exon12","subnormal_epo"],"properties":{"sex":{"enum":["female","male"],"type":"string","description":"female or male (Arber 2016 WHO 2016 PV hemoglobin/hematocrit thresholds). Required even when only increased_red_cell_mass is used. Assigned by the caller."},"subnormal_epo":{"type":"boolean","description":"Subnormal serum erythropoietin as assigned by the caller (Arber 2016 WHO 2016 minor criterion). true or false. magent does not assay EPO."},"hemoglobin_g_dl":{"type":"number","description":"Hemoglobin in g/dL (3-22). Major 1 meets when male >16.5 or female >16.0. Optional when hematocrit_percent is sent or increased_red_cell_mass is true. At least one of hemoglobin_g_dl, hematocrit_percent, or increased_red_cell_mass true is required. magent does not assay hemoglobin."},"hematocrit_percent":{"type":"number","description":"Hematocrit percent (10-70). Major 1 meets when male >49 or female >48. Optional when hemoglobin_g_dl is sent or increased_red_cell_mass is true. magent does not assay hematocrit."},"jak2_v617f_or_exon12":{"type":"boolean","description":"JAK2 V617F or JAK2 exon 12 mutation as assigned by the caller (Arber 2016 WHO 2016 major 3). true or false. magent does not sequence JAK2."},"bone_marrow_panmyelosis":{"type":"boolean","description":"WHO 2016 marrow major as assigned by the caller (age-adjusted hypercellularity with panmyelosis, including pleomorphic mature megakaryocytes). true or false. magent does not read slides."},"increased_red_cell_mass":{"type":"boolean","description":"Increased red-cell mass as assigned by the caller (Arber 2016 WHO 2016 major 1 alternative to Hb/Hct). true or false. true meets major 1 even when Hb/Hct are omitted or below threshold. magent does not measure red-cell mass."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_FZu-0rPP44V6GEsrqs02V","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Evaluates WHO 2016 (Arber 2016) polycythemia vera diagnostic criteria and returns whether the criteria are met based on caller-supplied hemoglobin, hematocrit, red-cell mass, bone marrow panmyelosis, JAK2 mutation status, and EPO findings.","exampleAgentPrompt":"Check whether this male patient meets WHO 2016 polycythemia vera criteria: hemoglobin is 17.1 g/dL, hematocrit is 51%, bone marrow panmyelosis is present, JAK2 V617F is positive, and serum EPO is subnormal.","exampleUseCases":[{"title":"Hematology EHR PV screening automation","prompt":"I have a female patient with hemoglobin 16.5 g/dL, hematocrit 49%, bone marrow panmyelosis confirmed, JAK2 V617F positive, and normal EPO — do the WHO 2016 Arber PV criteria say she has polycythemia vera?"},{"title":"Two-major-criteria pathway with subnormal EPO","prompt":"This male patient has hemoglobin 17.0 g/dL, hematocrit 50%, no bone marrow biopsy done yet, JAK2 V617F positive, and subnormal EPO — can you run the WHO 2016 PV criteria check to see if the two-major plus minor path is satisfied?"},{"title":"Increased red-cell mass pathway evaluation","prompt":"Patient has documented increased red-cell mass and confirmed bone marrow panmyelosis, JAK2 exon 12 mutation positive, sex is male, EPO is not subnormal — does this satisfy all three majors under WHO 2016 PV criteria?"}],"resultDescription":"Returns a structured result indicating whether the WHO 2016 (Arber 2016) polycythemia vera diagnostic criteria are met, which major criteria (1, 2, 3) were satisfied, whether the minor EPO criterion was triggered, and the overall diagnostic classification — without performing any laboratory assays itself.","failureModes":["Missing required parameters (sex, bone_marrow_panmyelosis, jak2_v617f_or_exon12, subnormal_epo) returns a validation error","No hemoglobin, hematocrit, or increased_red_cell_mass=true provided — at least one required, otherwise error","Hemoglobin value outside valid range 3–22 g/dL returns an error","Hematocrit value outside valid range 10–70% returns an error","Payment not included or invalid x402 payment results in 402 response"],"whenToPreferThis":"Use this endpoint when you need to programmatically apply the WHO 2016 (Arber 2016) polycythemia vera criteria — not WHO 2022 — and all clinical findings (JAK2, bone marrow, EPO, hemoglobin/hematocrit) have already been determined by the clinician or lab. It is not a substitute for clinical judgment, molecular assay, pathology review, or EPO measurement. Prefer this over manual scoring when embedding PV criteria checking into an automated hematology workflow, EHR decision-support tool, or agentic clinical pipeline.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T13:12:06.614Z","isFirstParty":false}