{"uid":"cap_HdC_UARHR_4zgEEVATkdL","slug":"2s-io-uniprotkb-protein-lookup-2a3b12f0","name":"2s.io UniProtKB Protein Lookup","description":"Look up a protein in UniProtKB by accession (e.g. \"P04637\", \"Q9Y6K9\", \"P0DTC2\"). Returns the entry id, reviewed (Swiss-Prot) flag, recommended + alternative protein names, gene names, organism + taxid, sequence length and molecular weight, the curated function description, subcellular locations, Gene Ontology terms (id + term + aspect: biological_process / molecular_function / cellular_component), PDB structure ids, and keywords. Bioinformatics, structural biology, drug-target research, education. Gene-centric sibling: /api/bio/gene. 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Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17189187, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:38653238, PubMed:9840937). Negatively regulates cell division by controlling expression of a set of genes required for this process (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:9840937). One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (PubMed:12524540, PubMed:17189187). Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (PubMed:12524540). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (PubMed:12524540). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492)","keywords":["3D-structure","Acetylation","Activator","Alternative promoter usage","Alternative splicing","Apoptosis","Biological rhythms","Cell cycle","Cytoplasm","Cytoskeleton","Direct protein sequencing","Disease variant","DNA-binding","Endoplasmic reticulum","Glycoprotein"],"lengthAa":393,"organism":{"taxid":9606,"commonName":"Human","scientificName":"Homo sapiens"},"reviewed":true,"accession":"P04637","uniprotUrl":"https://www.uniprot.org/uniprotkb/P04637","proteinName":"Cellular tumor antigen p53","pdbStructures":["1A1U","1AIE","1C26","1DT7","1GZH","1H26","1HS5","1JSP","1KZY","1MA3","1OLG","1OLH","1PES","1PET","1SAE","1SAF","1SAK","1SAL","1TSR","1TUP"],"alternativeNames":["Antigen NY-CO-13","Phosphoprotein p53","Tumor suppressor p53"],"molecularWeightDa":43653,"subcellularLocations":["Cytoplasm","Nucleus","Nucleus, PML body","Endoplasmic reticulum","Mitochondrion matrix","Cytoplasm, cytoskeleton, microtubule organizing center, centrosome"]}}],"total":1,"source":{"url":"https://www.uniprot.org/","license":"CC-BY 4.0 — attribute UniProt.","provider":"UniProt"}},"meta":{"cost":{"usd":0.00144,"tier":0},"caller":"x402","version":null,"endpoint":"bio.protein","settlement":{"txHash":"0xa494a73b5f56fdc26167a52bced1177ad42b4c8b42b655e7b93f3fbf35c9edaa","network":"eip155:8453","success":true}}}},"exampleRequest":{"accession":"P04637"},"tags":["x402"],"displayCostAmount":"0.00144","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"settled","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.00144/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.0036","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.0036","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_HC4ZaRTeam3jsV6JiKQZJ","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.0036","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Look up detailed protein metadata from UniProtKB by accession number, returning names, gene info, organism, sequence, function, structure, and ontology data.","exampleAgentPrompt":"Can you look up the UniProt entry for accession P04637 — I need its recommended protein name, gene name, organism, function description, subcellular locations, Gene Ontology terms, and any associated PDB structure IDs.","exampleUseCases":null,"resultDescription":"Returns a structured record for the protein including: entry ID, whether it is Swiss-Prot reviewed, recommended and alternative protein names, gene names, organism with taxon ID, sequence length and molecular weight, curated function description, subcellular locations, GO terms with IDs and aspects (biological_process, molecular_function, cellular_component), PDB structure IDs, and keyword tags.","failureModes":["Invalid or unrecognized accession returns 404 or empty result","Accession typo causes no match","Protein exists but is unreviewed (TrEMBL) — some fields may be sparse","Transient upstream UniProt data unavailability causes timeout or 5xx","Rate limiting or payment failure returns 402 or 429"],"whenToPreferThis":"Use this endpoint when you need rich, curated protein metadata — including function, GO terms, structure IDs, and subcellular localization — from UniProtKB given a known accession. 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