{"uid":"cap_GRh9ly6hiIzkUHokKEKdQ","slug":"simon-broome-register-1991-adult-definite-familial-605016a8","name":"Simon Broome Register 1991 Adult Definite Familial Hypercholesterolaemia Classifier","description":"Simon Broome Register 1991 adult definite familial hypercholesterolaemia: total cholesterol >7.5 mmol/L or LDL cholesterol >4.9 mmol/L plus tendon xanthomas in the patient or a relative (parent, child, grandparent, sibling, uncle, or aunt). One lipid (mmol/L or mg/dL). magent does not assay lipids or examine tendons. Not a diagnosis, not possible FH, and not a DNA or child-cutoff classifier.","url":"https://api.magentlab.com/api/calc/simon_broome","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["tendon_xanthoma_patient_or_relative"],"properties":{"ldl_mg_dl":{"type":"number","description":"LDL cholesterol in mg/dL (40-600). Converted to mmol/L as mg/dL / 38.67, then compared with >4.9. Provide exactly one lipid parameter."},"ldl_mmol_l":{"type":"number","description":"LDL cholesterol in mmol/L (1-15). Adult threshold is >4.9 mmol/L (4.9 does not meet). Provide exactly one lipid parameter. magent does not assay lipids."},"total_cholesterol_mg_dl":{"type":"number","description":"Total cholesterol in mg/dL (50-800). Converted to mmol/L as mg/dL / 38.67, then compared with >7.5. Provide exactly one lipid parameter."},"total_cholesterol_mmol_l":{"type":"number","description":"Total cholesterol in mmol/L (1.3-20). Adult threshold is >7.5 mmol/L (7.5 does not meet). Provide exactly one of total_cholesterol_mmol_l, total_cholesterol_mg_dl, ldl_mmol_l, or ldl_mg_dl. magent does not assay lipids."},"tendon_xanthoma_patient_or_relative":{"type":"boolean","description":"Tendon xanthomas in the patient or a relative (parent, child, grandparent, sibling, uncle, or aunt) as assigned by the caller. true or false. magent does not examine tendons or take a pedigree."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_7kaRaQ-kDRkuWXvctKLWX","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Applies the Simon Broome Register 1991 adult definite FH criteria: checks whether a single lipid value (total cholesterol >7.5 mmol/L or LDL >4.9 mmol/L) plus tendon xanthomas in the patient or a qualifying relative are both met.","exampleAgentPrompt":"My patient is an adult with a total cholesterol of 8.1 mmol/L and their sibling has tendon xanthomas — do they meet the Simon Broome 1991 adult definite familial hypercholesterolaemia criteria?","exampleUseCases":[{"title":"Adult patient with high total cholesterol","prompt":"I have an adult patient with a total cholesterol of 7.8 mmol/L and they personally have tendon xanthomas — does that satisfy the Simon Broome 1991 definite FH adult criteria?"},{"title":"LDL in mg/dL with family history xanthomas","prompt":"Can you check Simon Broome adult definite FH for a patient with an LDL of 210 mg/dL and a parent who has tendon xanthomas?"},{"title":"Borderline LDL without xanthomas","prompt":"My patient has an LDL of 5.0 mmol/L but neither they nor any qualifying relative has tendon xanthomas — do they meet Simon Broome 1991 adult definite FH?"}],"resultDescription":"Returns a structured result indicating whether the patient meets the Simon Broome 1991 adult definite FH criteria, including whether the lipid threshold (total cholesterol >7.5 mmol/L or LDL >4.9 mmol/L) is met and whether the tendon xanthoma criterion is satisfied. Does not provide a diagnosis, does not classify possible FH, and does not apply DNA or paediatric cutoffs.","failureModes":["More than one lipid parameter supplied — exactly one must be provided","Lipid value outside accepted range (e.g. LDL mmol/L outside 1–15) — input rejected","Missing required tendon_xanthoma_patient_or_relative parameter — request fails","Lipid value exactly at threshold (e.g. 7.5 mmol/L total cholesterol) — threshold is NOT met (strict >)","Payment not attached (x402) — 402 Payment Required response"],"whenToPreferThis":"Use this endpoint when you need to programmatically apply the Simon Broome Register 1991 adult definite FH criteria specifically — i.e., the two-component rule of a qualifying lipid value plus tendon xanthomas in patient or first/second-degree relative. Do not use it for possible FH classification, paediatric FH cutoffs, Dutch Lipid Clinic Network scoring, or DNA-based FH criteria.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-16T00:52:21.240Z","isFirstParty":false}