{"uid":"cap_FuJ2CNrHaYFIWJ57lJzKf","slug":"astct-crs-grader-lee-2019-d4fcae92","name":"ASTCT CRS Grader (Lee 2019)","description":"Lee 2019 ASTCT CRS Table 1 grade 0-4. Fever (>=38 C, not another cause) with both axes none is grade 1. fever_waived after antipyretic, tocilizumab, or steroids. Grade is the more severe of hypotension (none / no_vasopressors / one_vasopressor / multiple_vasopressors) vs hypoxia (none / low_flow / high_flow / positive_pressure). Organ toxicities do not influence grade. Not ICANS. magent does not measure temperature or start vasopressors.","url":"https://api.magentlab.com/api/calc/astct_crs","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["fever","fever_waived","hypotension","hypoxia"],"properties":{"fever":{"type":"boolean","description":"Fever as assigned by the caller (Lee 2019 ASTCT CRS Table 1): temperature ≥38°C not attributable to another cause. true or false. Required unless fever_waived is true when hypotension or hypoxia is not none. magent does not measure temperature."},"hypoxia":{"enum":["none","low_flow","high_flow","positive_pressure"],"type":"string","description":"Lee 2019 Table 1 hypoxia as assigned by the caller: none; low_flow (≤6 L/min nasal cannula or blow-by, grade 2); high_flow (>6 L/min nasal cannula, facemask, nonrebreather, or Venturi, grade 3); positive_pressure (CPAP, BiPAP, or intubation and mechanical ventilation, grade 4). magent does not set oxygen or ventilator mode."},"hypotension":{"enum":["none","no_vasopressors","one_vasopressor","multiple_vasopressors"],"type":"string","description":"Lee 2019 Table 1 hypotension as assigned by the caller: none; no_vasopressors (hypotension not requiring vasopressors, grade 2); one_vasopressor (one vasopressor with or without vasopressin, grade 3); multiple_vasopressors (multiple vasopressors excluding vasopressin, grade 4). magent does not start vasopressors."},"fever_waived":{"type":"boolean","description":"true if CRS was already treated with antipyretic, tocilizumab, or steroids so fever is no longer required to grade subsequent CRS (Lee 2019). false otherwise. magent does not start those therapies."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_9Wz2zmbNEJDRV-JAlgDlH","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Calculates the cytokine release syndrome (CRS) grade (0–4) per Lee 2019 ASTCT criteria from fever, hypotension, and hypoxia inputs","exampleAgentPrompt":"Grade this patient's CRS using the Lee 2019 ASTCT criteria: they have a fever of 38.5°C (fever = true, fever_waived = false), hypotension not requiring vasopressors, and they're on low-flow oxygen via nasal cannula.","exampleUseCases":[{"title":"Post-CAR-T CRS grading at bedside","prompt":"My CAR-T patient spiked a fever last night and now has low blood pressure that doesn't need vasopressors, and is on 3 L/min nasal cannula oxygen — fever is confirmed and was not treated with tocilizumab. What's their ASTCT CRS grade?"},{"title":"CRS re-grading after tocilizumab","prompt":"We gave the patient tocilizumab so fever is now waived; they still have high-flow oxygen via facemask and hypotension not requiring vasopressors. What CRS grade does that give them under Lee 2019?"},{"title":"CRS severity check before escalation decision","prompt":"Patient has no fever and fever is not waived, no hypotension, and no supplemental oxygen needed — can you confirm their ASTCT CRS grade so we know whether escalation is required?"}],"resultDescription":"Returns the ASTCT CRS grade (integer 0–4) based on the more severe of the hypotension and hypoxia axes, with grade 1 requiring only fever (when both axes are none), and fever requirement waivable after antipyretic, tocilizumab, or steroid administration.","failureModes":["Missing required query parameters (fever, fever_waived, hypotension, hypoxia) returns a validation error","Invalid enum values for hypotension or hypoxia return an error","fever is required unless fever_waived is true and hypotension or hypoxia is not none — omitting it otherwise causes an error","Network or payment failure (x402 payment required) if USDC payment is not provided"],"whenToPreferThis":"Use this endpoint when you need a precise, guideline-compliant ASTCT CRS grade (Lee 2019) computed from structured clinical inputs (fever, hypotension category, hypoxia category) — ideal for CAR-T cell therapy monitoring workflows, oncology clinical decision support agents, or audit-grade scoring where the exact grading rubric must be documented. Prefer this over general LLM reasoning when reproducibility and strict adherence to the published Lee 2019 Table 1 criteria are required. Not appropriate for ICANS grading or for endpoints that control clinical interventions.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-13T01:14:14.338Z","isFirstParty":false}