{"uid":"cap_FsLoubHZ98F6HVzu0th-L","slug":"wpss-who-based-prognostic-scoring-system-calculator-for-mds-7fe7213f","name":"WPSS (WHO-based Prognostic Scoring System) Calculator for MDS","description":"Malcovati 2007 WPSS for MDS: WHO category (RA/RARS/5q- 0, RCMD/RCMD-RS 1, RAEB-1 2, RAEB-2 3), IPSS karyotype (good 0, intermediate 1, poor 2; caller assigns the three-group class), regular RBC transfusion 1 (at least one every 8 weeks over 4 months); max 6. very_low 0 through very_high 5–6. Not IPSS-R, not IPSS 1997, not DIPSS. magent does not karyotype or assign WHO category.","url":"https://api.magentlab.com/api/calc/wpss","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["who_mds","cytogenetics","regular_transfusion"],"properties":{"who_mds":{"enum":["ra_rars_5q","rcmd","raeb1","raeb2"],"type":"string","description":"Malcovati 2007 Table 2 WHO 2001 group as assigned by the caller. ra_rars_5q is RA, RARS, or MDS with isolated del(5q) and scores 0. rcmd is RCMD or RCMD-RS and scores 1. raeb1 is RAEB-1 and scores 2. raeb2 is RAEB-2 and scores 3. magent does not assign WHO category."},"cytogenetics":{"enum":["good","intermediate","poor"],"type":"string","description":"IPSS (Greenberg 1997) cytogenetic group as assigned by the caller (good 0, intermediate 1, poor 2). Not the IPSS-R five-group scale (very_good and very_poor are invalid). magent does not karyotype."},"regular_transfusion":{"type":"boolean","description":"Regular RBC transfusion requirement as assigned by the caller (Malcovati 2007: at least one RBC transfusion every 8 weeks over 4 months). true scores 1. magent does not count units."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_Lkcl7ZPBh_LruPY9XuqKL","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the Malcovati 2007 WHO Prognostic Scoring System (WPSS) score and risk category for myelodysplastic syndromes from WHO MDS group, IPSS cytogenetic risk, and RBC transfusion status.","exampleAgentPrompt":"Calculate the WPSS score for my MDS patient: WHO category is RCMD, IPSS cytogenetics are intermediate risk, and they require regular RBC transfusions (at least one every 8 weeks).","exampleUseCases":[{"title":"MDS prognosis at initial staging","prompt":"My newly diagnosed MDS patient has been classified as RAEB-1 by WHO criteria, has poor cytogenetics by IPSS three-group classification, and needs regular RBC transfusions every 8 weeks. What is their WPSS score and risk category?"},{"title":"Low-risk MDS monitoring reassessment","prompt":"A patient with RA/RARS with isolated del(5q) has good cytogenetics and no regular transfusion requirement — can you run the WPSS to confirm their risk level is still very low?"},{"title":"Transplant eligibility clinical decision","prompt":"We're evaluating a patient with RCMD-RS, intermediate cytogenetics by IPSS, and regular transfusion dependence for stem cell transplant — please compute their WPSS score to support the eligibility discussion."}],"resultDescription":"Returns the computed WPSS total score (integer 0–6) and the corresponding ordinal risk category label (very_low, low, intermediate, high, or very_high) based on Malcovati 2007 criteria. The caller is responsible for pre-assigning WHO MDS category and IPSS three-group cytogenetic class.","failureModes":["Missing required query parameter (who_mds, cytogenetics, or regular_transfusion) returns a validation error","Invalid enum value for who_mds or cytogenetics (e.g. using IPSS-R five-group karyotype values like very_good or very_poor) returns an error","Incorrect interpretation of cytogenetics scale (five-group IPSS-R vs. three-group IPSS 1997) may silently produce wrong scores","Boolean parsing failure for regular_transfusion if not properly formatted"],"whenToPreferThis":"Use this endpoint when you need to apply the specific Malcovati 2007 WPSS system — not IPSS 1997 or IPSS-R — for MDS prognosis. The caller must have already assigned WHO 2001 MDS category and IPSS three-group cytogenetic risk externally; this endpoint handles only the arithmetic and risk-band classification. Prefer this over IPSS or IPSS-R calculators when the clinical context specifically requires WPSS, e.g. for longitudinal risk re-stratification or transfusion-weighted prognostication.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-16T00:54:36.232Z","isFirstParty":false}