{"uid":"cap_E8KYxalc63Tq1ULGSEfkj","slug":"cisne-febrile-neutropenia-risk-score-calculator-0ce99274","name":"CISNE Febrile Neutropenia Risk Score Calculator","description":"Carmona-Bayonas 2015 CISNE: ECOG ≥2 (2), stress hyperglycemia (2), COPD (1), chronic cardiovascular disease (1), NCI CTC mucositis ≥2 (1), monocytes <200/µL (1). Max 8. Low 0, intermediate 1–2, high ≥3. Seemingly stable adult solid-tumor febrile neutropenia only. Deterministic published score with citation; not MASCC; not an outpatient-chemotherapy or discharge order. magent does not assign ECOG, assay glucose, diagnose COPD, read an echocardiogram, grade mucositis, or count monocytes.","url":"https://api.magentlab.com/api/calc/cisne","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["ecog_ge_2","stress_hyperglycemia","copd","chronic_cardiovascular_disease","mucositis_nci_ge_2","monocytes_lt_200"],"properties":{"copd":{"type":"boolean","description":"COPD as assigned by the caller (Carmona-Bayonas 2015). true scores 1. magent does not diagnose COPD."},"ecog_ge_2":{"type":"boolean","description":"ECOG performance status ≥2 as assigned by the caller (Carmona-Bayonas 2015). true scores 2. magent does not assign ECOG."},"monocytes_lt_200":{"type":"boolean","description":"Monocytes <200 per µL as assigned by the caller (Carmona-Bayonas 2015). true scores 1. magent does not count monocytes."},"mucositis_nci_ge_2":{"type":"boolean","description":"NCI CTC mucositis grade ≥2 as assigned by the caller (Carmona-Bayonas 2015). true scores 1, not 3. magent does not grade mucositis."},"stress_hyperglycemia":{"type":"boolean","description":"Stress hyperglycemia as assigned by the caller (Carmona-Bayonas 2015). true scores 2. magent does not assay glucose."},"chronic_cardiovascular_disease":{"type":"boolean","description":"Chronic cardiovascular disease as assigned by the caller (Carmona-Bayonas 2015). true scores 1. magent does not read an echocardiogram."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":{"type":"json","example":{"path":"/api/calc/cisne","count":2,"items":[{"score":0,"formula":"cisne","citation":{"id":"carmona-bayonas-2015","doi":"10.1200/JCO.2014.57.2347","pmid":"25559804","title":"Prediction of serious complications in patients with seemingly stable febrile neutropenia: validation of the Clinical Index of Stable Febrile Neutropenia in a prospective cohort of patients from the FINITE study","source":"J Clin Oncol. 2015;33(5):465-471","authors":"Carmona-Bayonas A, Jiménez-Fonseca P, Virizuela Echaburu J, Antonio M, Font C, Biosca M, Ramchandani A, Martínez J, Hernando Cubero J, Espinosa J, Martínez de Castro E, Ghanem I, Beato C, Blasco A, Garrido M, Bonilla Y, Mondéjar R, Arcusa Lanza MÁ, Aragón Manrique I, Manzano A, Sevillano E, Castañón E, Cardona M, Gallardo Martín E, Pérez Armillas Q, Sánchez Lasheras F, Ayala de la Peña F"},"max_score":8,"cisne_band":"low","components":[{"factor":"ecog_ge_2","points":0,"present":false},{"factor":"stress_hyperglycemia","points":0,"present":false},{"factor":"copd","points":0,"present":false},{"factor":"chronic_cardiovascular_disease","points":0,"present":false},{"factor":"mucositis_nci_ge_2","points":0,"present":false},{"factor":"monocytes_lt_200","points":0,"present":false}],"disclaimer":"Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.","formula_expression":"CISNE = ecog_ge_2 2 + stress_hyperglycemia 2 + copd 1 + chronic_cardiovascular_disease 1 + mucositis_nci_ge_2 1 + monocytes_lt_200 1; Carmona-Bayonas 2015; max 8; low 0, intermediate 1-2, high ≥3"},{"score":0,"formula":"cisne","citation":{"id":"carmona-bayonas-2015","doi":"10.1200/JCO.2014.57.2347","pmid":"25559804","title":"Prediction of serious complications in patients with seemingly stable febrile neutropenia: validation of the Clinical Index of Stable Febrile Neutropenia in a prospective cohort of patients from the FINITE study","source":"J Clin Oncol. 2015;33(5):465-471","authors":"Carmona-Bayonas A, Jiménez-Fonseca P, Virizuela Echaburu J, Antonio M, Font C, Biosca M, Ramchandani A, Martínez J, Hernando Cubero J, Espinosa J, Martínez de Castro E, Ghanem I, Beato C, Blasco A, Garrido M, Bonilla Y, Mondéjar R, Arcusa Lanza MÁ, Aragón Manrique I, Manzano A, Sevillano E, Castañón E, Cardona M, Gallardo Martín E, Pérez Armillas Q, Sánchez Lasheras F, Ayala de la Peña F"},"max_score":8,"cisne_band":"low","components":[{"factor":"ecog_ge_2","points":0,"present":false},{"factor":"stress_hyperglycemia","points":0,"present":false},{"factor":"copd","points":0,"present":false},{"factor":"chronic_cardiovascular_disease","points":0,"present":false},{"factor":"mucositis_nci_ge_2","points":0,"present":false},{"factor":"monocytes_lt_200","points":0,"present":false}],"disclaimer":"Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.","formula_expression":"CISNE = ecog_ge_2 2 + stress_hyperglycemia 2 + copd 1 + chronic_cardiovascular_disease 1 + mucositis_nci_ge_2 1 + monocytes_lt_200 1; Carmona-Bayonas 2015; max 8; low 0, intermediate 1-2, high ≥3"}]}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_k_frbJO9gpPksppCoCST_","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the Carmona-Bayonas 2015 CISNE score for stable adult solid-tumor febrile neutropenia patients, returning a numeric score and risk category (low/intermediate/high).","exampleAgentPrompt":"My patient is a solid-tumor adult with febrile neutropenia who looks clinically stable. They have ECOG ≥2, stress hyperglycemia, no COPD, no chronic cardiovascular disease, no mucositis grade ≥2, and monocytes are not below 200 — can you calculate their CISNE score and tell me what risk category they fall into?","exampleUseCases":[{"title":"Triage febrile neutropenia in oncology clinic","prompt":"I have a stable solid-tumor patient presenting with febrile neutropenia. Their ECOG is ≥2, they have stress hyperglycemia, no COPD, no chronic cardiovascular disease, no significant mucositis, and their monocytes are above 200. What does their CISNE score come out to, and are they low, intermediate, or high risk?"},{"title":"Automate CISNE scoring in oncology EHR workflow","prompt":"For this cancer patient with neutropenic fever, flags are: ECOG ≥2 yes, stress hyperglycemia yes, COPD yes, chronic cardiovascular disease no, NCI mucositis grade ≥2 no, monocytes below 200 yes — please run the CISNE calculator and give me the score and risk class."},{"title":"Compare risk before deciding on outpatient management","prompt":"We're considering outpatient management for a stable adult with solid-tumor febrile neutropenia. ECOG is below 2, no stress hyperglycemia, no COPD, no cardiovascular disease, no mucositis grade ≥2, and monocytes are normal. Can you compute the CISNE score so I can see their risk level?"}],"resultDescription":"Returns the numeric CISNE total score (0–8) and the associated risk category: low (0), intermediate (1–2), or high (≥3), based on the six caller-supplied boolean clinical flags weighted per the Carmona-Bayonas 2015 publication.","failureModes":["Missing required boolean parameter returns a validation error","Passing numeric or non-boolean values for flag fields causes schema rejection","Applying the score to pediatric patients, hematologic malignancies, or unstable patients is a clinical misuse outside the instrument's validated population","Score does not incorporate clinical judgment — caller must independently verify each input flag before submission"],"whenToPreferThis":"Use this endpoint when you need a deterministic, citation-backed CISNE risk score for a seemingly stable adult solid-tumor febrile neutropenia patient and all six clinical flags have already been assessed by a clinician. Prefer CISNE over MASCC when the validated population (solid tumor, clinically stable) matches. Do not use for pediatric patients, hematologic malignancies, or unstable presentations.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-15T13:10:07.586Z","isFirstParty":false}