{"uid":"cap_Dn970GvRWBbXqZD4Q1pCT","slug":"hegele-2025-nafcs-score-calculator-fcs-likelihood-a6228e1e","name":"Hegele 2025 NAFCS Score Calculator (FCS Likelihood)","description":"Hegele 2025 NAFCS. Table 3 points from age or early HTG onset, BMI, abdominal pain or pancreatitis, secondary factors, fasting TG >880 mg/dL or >10 mmol/L, TG/TC >8 (mg/dL) or >3.5 (mmol/L), and apo B <1.0 g/L, plus published interactions. Max 100. ≥60 definite classical FCS; ≥45 very likely. Not a diagnosis or genetic test. Not Simon Broome or Dutch FH. magent does not examine the patient or assay lipids. Not a medical device.","url":"https://api.magentlab.com/api/calc/nafcs","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["age_years","htg_onset_before_age_10","bmi_below_threshold","abdominal_history","secondary_factors_present"],"properties":{"tg_mg_dl":{"type":"number","description":"Caller-assigned fasting triglycerides in mg/dL (440-20000) representing all readings used in the score (Hegele 2025 Table 1: last 3 labs in adults, last 2 in children). All readings >880 score 13. Provide exactly one of tg_mg_dl or tg_mmol_l. magent does not assay lipids."},"age_years":{"type":"integer","description":"Current age in whole years (1-120). Hegele 2025 Table 3: ages 1-9 score child_htg 12; ages ≥10 score early_htg_onset 12 only when htg_onset_before_age_10 is true. The score does not provide a value for infants <1 year. magent does not examine the patient."},"apo_b_g_l":{"type":"number","description":"Apolipoprotein B in g/L (0.1-3.0). <1.0 scores 12 (Hegele 2025 Table 3). Provide exactly one of apo_b_g_l or apo_b_mg_dl. 1.0 g/L = 100 mg/dL in the paper. magent does not assay apo B."},"tg_mmol_l":{"type":"number","description":"Caller-assigned fasting triglycerides in mmol/L (5-226). All readings >10 score 13. Provide exactly one of tg_mg_dl or tg_mmol_l. magent does not assay lipids."},"apo_b_mg_dl":{"type":"number","description":"Apolipoprotein B in mg/dL (10-300). <100 scores 12. Provide exactly one of apo_b_g_l or apo_b_mg_dl. magent does not assay apo B."},"abdominal_history":{"enum":["none","abdominal_pain","pancreatitis"],"type":"string","description":"Caller-assigned chylomicronemia-related abdominal history (Hegele 2025 Table 3): none (0), abdominal_pain = recurrent abdominal pain without pancreatitis (9), pancreatitis = history of pancreatitis with or without abdominal pain (16). magent does not diagnose pancreatitis."},"tg_tc_ratio_mg_dl":{"type":"number","description":"Triglyceride/total-cholesterol ratio when both are in mg/dL (0.1-80). >8 scores 8 (Hegele 2025 Table 1). Provide exactly one of tg_tc_ratio_mg_dl or tg_tc_ratio_mmol_l. magent does not assay lipids."},"tg_tc_ratio_mmol_l":{"type":"number","description":"Triglyceride/total-cholesterol ratio when both are in mmol/L (0.1-35). >3.5 scores 8. Provide exactly one of tg_tc_ratio_mg_dl or tg_tc_ratio_mmol_l. magent does not assay lipids."},"bmi_below_threshold":{"type":"boolean","description":"BMI <25.0 kg/m2 in adults or <85th percentile in children/adolescents as assigned by the caller (Hegele 2025 Table 3, 9 points). true or false. magent does not compute BMI or pediatric percentiles."},"htg_onset_before_age_10":{"type":"boolean","description":"Hypertriglyceridemia onset in infancy or childhood (before age 10) as assigned by the caller (Hegele 2025 Table 1). true or false. Scores 12 only when age_years ≥10. For ages 1-9, child_htg is scored from age and this flag does not add points. magent does not date onset."},"secondary_factors_present":{"type":"boolean","description":"One or more secondary factors that may contribute to hypertriglyceridemia as assigned by the caller (Hegele 2025 Table 1: lifestyle, medications, clinical conditions). true (≥1, 0 points) or false (none, 11 points, plus published interactions). magent does not take a history."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm__cl2jcKa6jc1BDyUULCWH","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the Hegele 2025 North American Familial Chylomicronemia Syndrome (NAFCS) clinical score to estimate likelihood of classical FCS based on age, lipid values, BMI, and clinical history","exampleAgentPrompt":"Score this patient for familial chylomicronemia syndrome using the Hegele 2025 NAFCS criteria: she's 34 years old, her HTG started before age 10, BMI is below threshold, she has a history of pancreatitis, secondary factors are present, fasting TGs are 1200 mg/dL, TG/TC ratio is 9, and apo B is 0.7 g/L — what's her NAFCS score and does she meet the definite FCS threshold?","exampleUseCases":[{"title":"Rare lipid disorder pre-screening","prompt":"I have a 28-year-old male patient, HTG onset before age 10, BMI below threshold, with recurrent abdominal pain (no pancreatitis), secondary factors present, fasting TGs at 950 mg/dL, TG/TC of 8.5, and apo B of 0.85 g/L — run the Hegele 2025 NAFCS score and tell me if he's likely classical FCS."},{"title":"Pediatric hypertriglyceridemia workup","prompt":"My patient is 7 years old with very high triglycerides — 1100 mg/dL fasting, TG/TC ratio of 9.2, apo B of 60 mg/dL, BMI below threshold, a history of abdominal pain, and secondary factors present. Can you compute the NAFCS score to see if this looks like familial chylomicronemia?"},{"title":"Lipid clinic decision support","prompt":"For a 45-year-old female at our lipid clinic: no early HTG onset, BMI above threshold, no abdominal pain or pancreatitis, secondary factors absent, fasting TGs of 500 mg/dL, TG/TC of 5, and apo B of 1.2 g/L — what does the Hegele 2025 NAFCS scoring give her, and is she in the 'very likely' or 'definite' FCS range?"}],"resultDescription":"Returns an integer NAFCS score from 0–100 with a per-criterion point breakdown. Scores ≥60 indicate definite classical FCS; scores ≥45 indicate very likely FCS. The result is an arithmetic clinical scoring aid, not a diagnosis, genetic test, or output from a medical device.","failureModes":["Missing required parameters (age_years, htg_onset_before_age_10, bmi_below_threshold, abdominal_history, secondary_factors_present) returns a 400 error","Providing both tg_mg_dl and tg_mmol_l simultaneously causes a validation error","TG values outside range (mg/dL 440–20000 or mmol/L 5–226) rejected","Age below 1 year not supported by the scoring model","Providing both apo_b_g_l and apo_b_mg_dl simultaneously causes a validation error","Payment failure (x402) results in 402 response requiring USDC payment"],"whenToPreferThis":"Use this endpoint when you need to apply the Hegele 2025 NAFCS clinical scoring table to estimate the likelihood of familial chylomicronemia syndrome (FCS/LPL deficiency) in a patient. Choose this over generic hypertriglyceridemia tools when the specific Hegele 2025 North American criteria (Table 3 point system) are required. Not appropriate for Simon Broome or Dutch FH scoring, genetic testing interpretation, or patients under 1 year of age.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-15T01:21:31.921Z","isFirstParty":false}