{"uid":"cap_AvrUBQBAkHRx0yHYqF1oc","slug":"sledai-2k-calculator-gladman-2002-3fb377c1","name":"SLEDAI-2K Calculator (Gladman 2002)","description":"Gladman 2002 SLEDAI-2K: weighted sum of 24 caller-assigned descriptors present in the last 10 days (max 105). magent does not examine the patient. Proteinuria scores if >0.5 g/24 h (not original SLEDAI >3.5 g/24 h only). Rash, alopecia, and mucosal ulcers score if new or persistent (not new only). Not a diagnosis, not SLICC damage, not SELENA-SLEDAI flare rules, and not a medical device.","url":"https://api.magentlab.com/api/calc/sledai_2k","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["seizure","psychosis","organic_brain_syndrome","visual_disturbance","cranial_nerve_disorder","lupus_headache","cva","vasculitis","arthritis","myositis","urinary_casts","hematuria","proteinuria","pyuria","rash","alopecia","mucosal_ulcers","pleurisy","pericarditis","low_complement","increased_dna_binding","fever","thrombocytopenia","leukopenia"],"properties":{"cva":{"type":"boolean","description":"Cerebrovascular accident in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): new onset of CVA(s). Exclude arteriosclerosis. true scores 8. magent does not read imaging."},"rash":{"type":"boolean","description":"Rash in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): inflammatory type rash. Scores if new or persistent (not original SLEDAI new only). true scores 2. magent does not examine skin."},"fever":{"type":"boolean","description":"Fever in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): >38°C. Exclude infectious cause. true scores 1. magent does not measure temperature."},"pyuria":{"type":"boolean","description":"Pyuria in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): >5 white blood cells/high power field. Exclude infection. true scores 4. magent does not assay urine."},"seizure":{"type":"boolean","description":"Seizure in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K). Recent onset. Exclude metabolic, infectious, or drug cause. true scores 8. magent does not examine the patient."},"alopecia":{"type":"boolean","description":"Alopecia in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): abnormal, patchy or diffuse loss of hair. Scores if new or persistent (not original SLEDAI new only). true scores 2. magent does not examine the scalp."},"myositis":{"type":"boolean","description":"Myositis in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): proximal muscle aching/weakness with elevated creatine phosphokinase/aldolase, EMG changes, or a biopsy showing myositis. true scores 4. magent does not assay muscle enzymes."},"pleurisy":{"type":"boolean","description":"Pleurisy in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): pleuritic chest pain with pleural rub or effusion, or pleural thickening. true scores 2. magent does not examine the chest."},"arthritis":{"type":"boolean","description":"Arthritis in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): more than 2 joints with pain and signs of inflammation (tenderness, swelling, or effusion). true scores 4. magent does not examine joints."},"hematuria":{"type":"boolean","description":"Hematuria in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): >5 red blood cells/high power field. Exclude stone, infection, or other cause. true scores 4. magent does not assay urine."},"psychosis":{"type":"boolean","description":"Psychosis in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): altered ability to function in normal activity due to severe disturbance in the perception of reality. Exclude uremia and drug causes. true scores 8. magent does not examine the patient."},"leukopenia":{"type":"boolean","description":"Leukopenia in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): <3,000 white blood cells/mm³. Exclude drug causes. true scores 1. magent does not assay blood counts."},"vasculitis":{"type":"boolean","description":"Vasculitis in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): ulceration, gangrene, tender finger nodules, periungual infarction, splinter hemorrhages, or biopsy or angiogram proof of vasculitis. true scores 8. magent does not examine skin or read a biopsy."},"proteinuria":{"type":"boolean","description":"Proteinuria in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): >0.5 g/24 h (not original SLEDAI >3.5 g/24 h only). true scores 4. magent does not assay urine."},"pericarditis":{"type":"boolean","description":"Pericarditis in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): pericardial pain with at least one of rub, effusion, or electrocardiogram or echocardiogram confirmation. true scores 2. magent does not examine the heart."},"urinary_casts":{"type":"boolean","description":"Urinary casts in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): heme-granular or red blood cell casts. true scores 4. magent does not assay urine."},"low_complement":{"type":"boolean","description":"Low complement in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): CH50, C3, or C4 below the lower limit of normal for the testing laboratory. true scores 2. magent does not assay complement."},"lupus_headache":{"type":"boolean","description":"Lupus headache in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): severe persistent headache; may be migrainous, but must be nonresponsive to narcotic analgesia. true scores 8. magent does not examine the patient."},"mucosal_ulcers":{"type":"boolean","description":"Mucosal ulcers in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): oral or nasal ulcerations. Scores if new or persistent (not original SLEDAI new only). true scores 2. magent does not examine mucosa."},"thrombocytopenia":{"type":"boolean","description":"Thrombocytopenia in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): <100,000 platelets/mm³. Exclude drug causes. true scores 1. magent does not assay platelets."},"visual_disturbance":{"type":"boolean","description":"Visual disturbance in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): retinal changes of SLE (cytoid bodies, retinal hemorrhages, serous exudate or hemorrhages in the choroid, or optic neuritis). Exclude hypertension, infection, or drug causes. true scores 8. magent does not examine the fundus."},"increased_dna_binding":{"type":"boolean","description":"Increased DNA binding in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): DNA binding by Farr assay above the normal range for the testing laboratory. true scores 2. magent does not assay anti-dsDNA."},"cranial_nerve_disorder":{"type":"boolean","description":"Cranial nerve disorder in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): new onset of sensory or motor neuropathy involving cranial nerves. true scores 8. magent does not examine cranial nerves."},"organic_brain_syndrome":{"type":"boolean","description":"Organic brain syndrome in the last 10 days as assigned by the caller (Gladman 2002 SLEDAI-2K): altered mental function with impaired orientation, memory, or other intellectual function, rapid onset and fluctuating features. Exclude metabolic, infectious, or drug causes. true scores 8. magent does not examine the patient."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_jKPNyas9hCdCA7K9bELc5","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the SLEDAI-2K disease activity score for systemic lupus erythematosus from 24 caller-assigned clinical descriptors observed in the last 10 days","exampleAgentPrompt":"Calculate the SLEDAI-2K score for my lupus patient: over the last 10 days she had a seizure (true), rash (true), arthritis (true), fever (true), low complement (true), increased DNA binding (true), and all other 18 descriptors are false — give me the weighted total.","exampleUseCases":[{"title":"Rheumatology clinic follow-up scoring","prompt":"My SLE patient at today's follow-up has had arthritis, rash, alopecia, and low complement over the past 10 days; seizure, psychosis, organic brain syndrome, visual disturbance, cranial nerve disorder, lupus headache, CVA, vasculitis, myositis, urinary casts, hematuria, proteinuria, pyuria, mucosal ulcers, pleurisy, pericarditis, increased DNA binding, fever, thrombocytopenia, and leukopenia are all absent. What's her SLEDAI-2K score?"},{"title":"Research data pipeline activity indexing","prompt":"For a lupus cohort study, I need to compute SLEDAI-2K scores programmatically. This patient visit record shows seizure=false, psychosis=false, organic_brain_syndrome=false, visual_disturbance=false, cranial_nerve_disorder=false, lupus_headache=false, cva=false, vasculitis=true, arthritis=true, myositis=false, urinary_casts=true, hematuria=true, proteinuria=true, pyuria=false, rash=false, alopecia=false, mucosal_ulcers=false, pleurisy=false, pericarditis=false, low_complement=true, increased_dna_binding=true, fever=false, thrombocytopenia=true, leukopenia=false. Calculate the score."},{"title":"Flare monitoring between clinic visits","prompt":"My lupus patient called in reporting new fever and pleurisy symptoms this week — everything else from our descriptor list is negative. Can you run the SLEDAI-2K calculation so I can document her current disease activity before her next visit?"}],"resultDescription":"Returns an integer SLEDAI-2K score (0–105) representing the weighted sum of the 24 present descriptors. Higher scores indicate greater lupus disease activity. The Gladman 2002 variant scores proteinuria if >0.5 g/24h and counts rash, alopecia, and mucosal ulcers whether new or persistent.","failureModes":["Missing any of the 24 required boolean query parameters returns an error","Non-boolean values for descriptor flags cause validation failure","Network timeout or server error returns HTTP 5xx","Incorrect USDC payment or missing x402 payment header returns 402 Payment Required"],"whenToPreferThis":"Use this endpoint when you need a standardized, reproducible SLEDAI-2K integer score computed from discrete clinical boolean flags using the Gladman 2002 criteria — particularly when you need the modified proteinuria threshold (>0.5 g/24h) and the persistent (not only new) scoring for rash, alopecia, and mucosal ulcers. Prefer over manual calculation to eliminate arithmetic errors in research or clinical documentation workflows.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-15T01:21:16.725Z","isFirstParty":false}