{"uid":"cap_AJuraDlfQMtHGcNGMlhoW","slug":"fardet-2014-hscore-calculator-d6c97d54","name":"Fardet 2014 HScore Calculator","description":"Fardet 2014 HScore (Table 4; max 337) from nine caller-assigned items: immunosuppression 18, temperature 0/33/49, organomegaly 0/23/38, cytopenia lineages 0/24/34 (1/2/3), ferritin 0/35/50, triglycerides 0/44/64, fibrinogen 0/30, SGOT 0/19, marrow hemophagocytosis 35. Best cutoff 169. magent does not take raw labs; all nine required. Not HLH-2004. Not a diagnosis. Not a medical device.","url":"https://api.magentlab.com/api/calc/hscore","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["immunosuppression","temperature_band","organomegaly","cytopenia_lineages","ferritin_band","triglyceride_band","fibrinogen_band","sgot_band","marrow_hemophagocytosis"],"properties":{"sgot_band":{"type":"string","description":"Caller-assigned Fardet 2014 Table 4 SGOT/AST band (IU/L). lt_30 (<30) scores 0; ge_30 (≥30) scores 19. magent does not take a raw SGOT."},"organomegaly":{"type":"string","description":"Caller-assigned Fardet 2014 Table 4 organomegaly. none scores 0; hepato_or_spleno (hepatomegaly or splenomegaly) scores 23; hepato_and_spleno (hepatomegaly and splenomegaly) scores 38. magent does not examine the patient."},"ferritin_band":{"type":"string","description":"Caller-assigned Fardet 2014 Table 4 ferritin band (ng/ml). lt_2000 (<2000) scores 0; 2000_to_6000 (2000–6000) scores 35; gt_6000 (>6000) scores 50. magent does not take a raw ferritin."},"fibrinogen_band":{"type":"string","description":"Caller-assigned Fardet 2014 Table 4 fibrinogen band (g/L). gt_2_5 (>2.5) scores 0; le_2_5 (≤2.5) scores 30. magent does not take a raw fibrinogen."},"temperature_band":{"type":"string","description":"Caller-assigned Fardet 2014 Table 4 temperature band (°C). lt_38_4 (<38.4) scores 0; 38_4_to_39_4 (38.4–39.4) scores 33; gt_39_4 (>39.4) scores 49. magent does not take a raw temperature."},"immunosuppression":{"type":"boolean","description":"Known underlying immunosuppression as assigned by the caller (Fardet 2014 Table 4 footnote: HIV positive or long-term glucocorticoids, cyclosporine, or azathioprine). true scores 18; false scores 0."},"triglyceride_band":{"type":"string","description":"Caller-assigned Fardet 2014 Table 4 triglyceride band (mmol/L). lt_1_5 (<1.5) scores 0; 1_5_to_4 (1.5–4.0) scores 44; gt_4 (>4.0) scores 64. magent does not take a raw triglyceride."},"cytopenia_lineages":{"type":"integer","description":"Caller-assigned number of cytopenia lineages (integer 1, 2, or 3). 1 scores 0; 2 scores 24; 3 scores 34. Zero cytopenias were not assessed in Fardet 2014 and are rejected. Cytopenia definition (paper footnote, caller already applied): Hb ≤9.2 g/dL and/or WBC ≤5000/mm³ and/or platelets ≤110000/mm³. magent does not take those labs."},"marrow_hemophagocytosis":{"type":"boolean","description":"Hemophagocytosis features on bone marrow aspirate as assigned by the caller (Fardet 2014 Table 4). true scores 35; false scores 0. Not required for a diagnosis; this tool is not a diagnosis."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_HjAR7HFGwp56IvOszCgw_","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the HScore (max 337) for reactive hemophagocytic syndrome probability using nine caller-assigned Fardet 2014 Table 4 items, with a best cutoff of 169.","exampleAgentPrompt":"Calculate the Fardet 2014 HScore for a patient with immunosuppression (true), temperature 39.8°C (gt_39_4 band), hepatomegaly and splenomegaly (hepato_and_spleno), 2 cytopenia lineages, ferritin 8000 ng/mL (gt_6000 band), triglycerides in the high band (gt_5_5), fibrinogen 1.8 g/L (le_2_5 band), SGOT ≥30 (ge_30 band), and marrow hemophagocytosis present — what is the HScore and how does it compare to the 169 cutoff?","exampleUseCases":[{"title":"ICU hemophagocytic syndrome risk triage","prompt":"My ICU patient has immunosuppression, temp over 39.4°C, both hepato- and splenomegaly, 3 cytopenia lineages, ferritin above 6000, triglycerides over 5.5, fibrinogen at 2.0 g/L, AST above 30, and marrow hemophagocytosis confirmed — run the Fardet HScore for me."},{"title":"Rheumatology consult pre-assessment","prompt":"Before the rheumatology consult, compute the HScore for a patient with no immunosuppression, temperature 38.8°C (38_4_to_39_4 band), splenomegaly only, 1 cytopenic lineage, ferritin 3000 ng/mL, triglycerides below 1.5 (lt_1_5 band), fibrinogen 3.0 g/L, AST below 30, and no marrow hemophagocytosis documented."},{"title":"Tracking HScore across treatment","prompt":"Re-score the HScore for a patient now showing no immunosuppression, temp below 38.4°C, no organomegaly, 1 cytopenia lineage, ferritin under 2000, triglycerides below 1.5, fibrinogen above 2.5, AST below 30, and no marrow hemophagocytosis — did they drop below the 169 cutoff after treatment?"}],"resultDescription":"Returns the computed HScore integer (0–337) derived from the nine Fardet 2014 Table 4 items. A score ≥169 is the published best cutoff associated with reactive hemophagocytic syndrome. The result is a numerical score only — not a diagnosis, not a medical device output.","failureModes":["Missing any of the nine required query parameters returns an error — all are mandatory","Invalid enum string values for band parameters (e.g. unrecognized temperature_band string) cause a validation error","Passing raw numeric lab values instead of caller-assigned band strings will fail schema validation","Non-boolean value for immunosuppression field causes a type error"],"whenToPreferThis":"Use this endpoint when you have already translated raw clinical findings into the nine Fardet 2014 Table 4 categorical bands and need a precise, reproducible HScore computation. Prefer this over manual calculation to avoid arithmetic errors. This is specifically the Fardet 2014 HScore — not HLH-2004 criteria, not the 2016 HScore revision, and not any other hemophagocytosis scoring system.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T13:11:06.400Z","isFirstParty":false}