{"uid":"cap_9G4oMw0pf-xF2v-lzrFEI","slug":"magent-rome-iv-reflux-hypersensitivity-calculator-22e4911f","name":"magent Rome IV Reflux Hypersensitivity Calculator","description":"Aziz 2016 Rome IV reflux hypersensitivity. rome_iv_reflux_hypersensitivity is true iff retrosternal heartburn or chest pain, normal endoscopy without EoE, no motor disorder, reflux-triggered despite normal acid, 3- and 6-month timing. Caller assigns six flags. magent does not read pH-impedance or endoscopy. Antisecretory response does not exclude the diagnosis and is not a required flag. Not a diagnosis, not functional heartburn, not GERD/NERD as the primary tool, not globus.","url":"https://api.magentlab.com/api/calc/rome_iv_reflux_hypersensitivity","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["retrosternal_heartburn_or_chest_pain","normal_endoscopy_no_eoe","no_major_esophageal_motor_disorder","symptoms_triggered_by_reflux_despite_normal_acid_exposure","fulfilled_last_3_months","onset_at_least_6_months"],"properties":{"fulfilled_last_3_months":{"type":"boolean","description":"Criteria fulfilled for the last 3 months, as assigned (Aziz 2016). true or false as assigned by the caller. magent does not take a history."},"normal_endoscopy_no_eoe":{"type":"boolean","description":"Normal endoscopy and absence of evidence that eosinophilic esophagitis is the cause, as assigned (Aziz 2016). true or false as assigned by the caller. magent does not read endoscopy."},"onset_at_least_6_months":{"type":"boolean","description":"Symptom onset at least 6 months prior to diagnosis, as assigned (Aziz 2016). true or false as assigned by the caller. magent does not take a history."},"no_major_esophageal_motor_disorder":{"type":"boolean","description":"Absence of a major esophageal motor disorder, as assigned (Aziz 2016). true or false as assigned by the caller. magent does not interpret manometry."},"retrosternal_heartburn_or_chest_pain":{"type":"boolean","description":"Retrosternal symptoms including heartburn and chest pain, as assigned (Aziz 2016). true or false as assigned by the caller. magent does not examine the patient."},"symptoms_triggered_by_reflux_despite_normal_acid_exposure":{"type":"boolean","description":"Evidence that symptoms are triggered by reflux events despite normal acid exposure on pH or pH-impedance, as assigned (Aziz 2016). true or false as assigned by the caller. magent does not parse traces."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_LWKMvKpWFB3kG-SqJwgQW","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Evaluates whether a patient meets the Rome IV diagnostic criteria for reflux hypersensitivity based on six caller-assigned boolean flags","exampleAgentPrompt":"My patient has retrosternal heartburn and chest pain, a normal endoscopy with no eosinophilic esophagitis, no esophageal motor disorder, and pH-impedance shows symptoms triggered by reflux events despite normal acid exposure — symptoms have been present for 8 months and criteria have been met for the last 4 months. Do they meet Rome IV reflux hypersensitivity criteria?","exampleUseCases":[{"title":"GI clinic pre-consultation triage","prompt":"I'm seeing a patient with chronic retrosternal heartburn, a normal upper endoscopy, no signs of EoE, no motor disorder on manometry, and pH-impedance confirming reflux-triggered symptoms despite normal acid — symptoms started 9 months ago and have been consistent for the past 3 months. Can you check if they qualify for Rome IV reflux hypersensitivity?"},{"title":"Teaching case classification for medical education","prompt":"For a teaching scenario: patient has chest pain that's retrosternal, endoscopy is normal with no EoE, no major esophageal motor disorder detected, reflux events correlate with symptoms despite normal acid exposure, criteria met for last 3 months, onset was 7 months ago. Does this case meet Rome IV reflux hypersensitivity per Aziz 2016?"},{"title":"Clinical research eligibility screening","prompt":"I need to screen a research participant: they have retrosternal heartburn, normal endoscopy without EoE, no esophageal motor disorder, symptom-reflux association confirmed despite normal acid on pH study, criteria fulfilled for the past 3 months, and symptoms started over 6 months ago. Do they meet the Rome IV reflux hypersensitivity definition?"}],"resultDescription":"Returns a boolean field `rome_iv_reflux_hypersensitivity` — true if all six Rome IV criteria for reflux hypersensitivity (Aziz 2016) are met, false otherwise. No clinical interpretation, history-taking, endoscopy reading, or pH-impedance analysis is performed; the caller is responsible for assigning all flags.","failureModes":["Missing required boolean flags returns a validation error","Misassignment of flags by caller leads to incorrect output (garbage-in, garbage-out)","Endpoint does not validate clinical plausibility of flag combinations","Network or payment (x402) failures may return HTTP 402 or 5xx errors"],"whenToPreferThis":"Use this endpoint when you need a fast, structured computation of Rome IV reflux hypersensitivity criteria (Aziz 2016) and the caller has already determined all six clinical flags from the patient record or history. Prefer this over manual checklist review when automating GI clinical decision support, research screening, or educational case classification. Do not use this to diagnose GERD/NERD as the primary tool, functional heartburn, or globus — those require different Rome IV calculators.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T07:01:47.935Z","isFirstParty":false}