{"uid":"cap_8W72GdZdayko08YzFQuiy","slug":"motzer-1999-mskcc-rcc-prognostic-score-7b67cc35","name":"Motzer 1999 MSKCC RCC Prognostic Score","description":"Motzer 1999 MSKCC: KPS <80, LDH >1.5×ULN, hemoglobin <LLN, corrected calcium >10 mg/dL, no prior nephrectomy; 1 point each, max 5. Favorable 0, intermediate 1–2, poor ≥3. Deterministic published score with citation; not an RCC diagnosis or treatment recommendation; not IMDC; not Motzer 2002/2004. magent does not assign KPS or assay LDH, hemoglobin, or calcium.","url":"https://api.magentlab.com/api/calc/motzer","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["kps_lt_80","ldh_gt_1_5_uln","hemoglobin_lt_lln","corrected_calcium_gt_10","no_prior_nephrectomy"],"properties":{"kps_lt_80":{"type":"boolean","description":"Karnofsky performance status <80% as assigned by the caller (Motzer 1999). true scores 1. magent does not observe KPS."},"ldh_gt_1_5_uln":{"type":"boolean","description":"Serum LDH >1.5 × institutional ULN as assigned by the caller (Motzer 1999). true scores 1. magent does not assay LDH or apply ULN."},"hemoglobin_lt_lln":{"type":"boolean","description":"Hemoglobin below the institutional lower limit of normal as assigned by the caller (Motzer 1999). true scores 1. magent does not assay hemoglobin or apply LLN."},"no_prior_nephrectomy":{"type":"boolean","description":"Absence of prior nephrectomy as assigned by the caller (Motzer 1999). true scores 1. Not Motzer 2004 time from diagnosis to treatment. magent does not review operative history."},"corrected_calcium_gt_10":{"type":"boolean","description":"Corrected calcium >10 mg/dL as assigned by the caller (Motzer 1999 paper threshold, not institutional ULN). true scores 1. magent does not assay calcium."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":null,"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_VQCyjKKPUtL6EpT5zUDZY","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Calculates the Motzer 1999 MSKCC prognostic score for metastatic renal cell carcinoma using five binary risk factors, yielding a risk group of favorable, intermediate, or poor.","exampleAgentPrompt":"Calculate the Motzer 1999 MSKCC prognostic score for a metastatic RCC patient who has KPS below 80, LDH above 1.5 times the upper limit of normal, hemoglobin below the lower limit of normal, corrected calcium above 10 mg/dL, and has not had a prior nephrectomy.","exampleUseCases":[{"title":"Stratifying newly diagnosed metastatic RCC","prompt":"My patient has newly diagnosed metastatic kidney cancer. Their KPS is less than 80, LDH is elevated above 1.5 times ULN, hemoglobin is below normal, corrected calcium is 11 mg/dL, and they haven't had a nephrectomy — what's their Motzer 1999 MSKCC risk group?"},{"title":"Favorable-risk RCC confirmation","prompt":"I have an RCC patient with normal KPS, normal LDH, normal hemoglobin, corrected calcium of 9 mg/dL, and they had a prior nephrectomy — can you run the Motzer 1999 score and tell me if they fall in the favorable risk category?"},{"title":"Embedding Motzer score in oncology workflow","prompt":"For our clinical trial eligibility pipeline, calculate the 1999 Motzer MSKCC score for a patient flagged as: KPS ≥80, LDH normal, hemoglobin normal, corrected calcium normal, prior nephrectomy done — give me the numeric score and risk group."}],"resultDescription":"Returns the total Motzer 1999 MSKCC score (0–5, one point per positive risk factor) and the corresponding risk group: favorable (0 points), intermediate (1–2 points), or poor (≥3 points), along with a citation to the original Motzer 1999 publication. Does not return a diagnosis, treatment recommendation, or IMDC classification.","failureModes":["Missing any of the five required boolean parameters returns a validation error","Passing non-boolean values for the risk factor fields causes a schema rejection","Confusing this with the IMDC (Heng 2009) model may yield incorrect risk stratification for immunotherapy-era patients","Confusing with Motzer 2002 or 2004 variants may cause misclassification if criteria differ"],"whenToPreferThis":"Use this endpoint when you need the original cytokine-era Motzer 1999 MSKCC five-factor prognostic model specifically (KPS, LDH, hemoglobin, corrected calcium, nephrectomy status). Prefer this over the IMDC/Heng 2009 endpoint when the clinical context calls for the historical Motzer 1999 criteria — e.g., cytokine-era trial comparisons or when the ordering clinician specifies the 1999 MSKCC model. Do not use this for IMDC risk stratification used in contemporary immunotherapy trials.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-14T00:52:50.700Z","isFirstParty":false}