{"uid":"cap_75BZOgvmqO_9weQLriglK","slug":"age-adjusted-d-dimer-cutoff-calculator-righini-2014-adjust-pe-cc701f56","name":"Age-Adjusted D-dimer Cutoff Calculator (Righini 2014 ADJUST-PE)","description":"Age-adjusted D-dimer cutoff (Righini 2014 ADJUST-PE). PE excluded only when D-dimer (ng/mL FEU) is strictly below 500 if age <50 or age×10 if age ≥50. Equality is not excluded. FEU only, not DDU; magent does not convert units. Not a diagnosis, not YEARS, not Wells.","url":"https://api.magentlab.com/api/calc/age_adjusted_dimer","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["age","d_dimer_ng_ml"],"properties":{"age":{"type":"integer","description":"Age in years (18-120). Cutoff is 500 ng/mL FEU when age < 50; age × 10 when age ≥ 50 (age 50 → 500)."},"d_dimer_ng_ml":{"type":"number","description":"D-dimer in ng/mL fibrinogen-equivalent units (FEU) as in Righini 2014 (0-20000). PE excluded only when strictly below the age-adjusted cutoff. Equality is not excluded. DDU and other units are not this tool."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":{"type":"json","example":{"path":"/api/calc/age_adjusted_dimer","count":2,"items":[{"formula":"age_adjusted_dimer","citation":{"id":"righini-2014","doi":"10.1001/jama.2014.2135","title":"Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study","source":"JAMA. 2014;311(11):1117-1124","authors":"Righini M, Van Es J, Den Exter PL, et al."},"criteria":[{"met":false,"value":40,"factor":"age_ge_50"}],"age_years":40,"disclaimer":"Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.","pe_excluded":true,"d_dimer_ng_ml":499,"ctpa_indicated":false,"formula_expression":"PE excluded iff d_dimer_ng_ml < (500 if age < 50 else age * 10); D-dimer is ng/mL FEU; equality is not excluded","d_dimer_threshold_ng_ml":500},{"formula":"age_adjusted_dimer","citation":{"id":"righini-2014","doi":"10.1001/jama.2014.2135","title":"Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study","source":"JAMA. 2014;311(11):1117-1124","authors":"Righini M, Van Es J, Den Exter PL, et al."},"criteria":[{"met":false,"value":40,"factor":"age_ge_50"}],"age_years":40,"disclaimer":"Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.","pe_excluded":true,"d_dimer_ng_ml":499,"ctpa_indicated":false,"formula_expression":"PE excluded iff d_dimer_ng_ml < (500 if age < 50 else age * 10); D-dimer is ng/mL FEU; equality is not excluded","d_dimer_threshold_ng_ml":500}]}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_PBUvKJIPdQMe54eO__Wyg","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Calculates whether PE can be excluded based on the Righini 2014 ADJUST-PE age-adjusted D-dimer cutoff: below 500 ng/mL FEU if age <50, or below age×10 ng/mL FEU if age ≥50.","exampleAgentPrompt":"My patient is 67 years old and has a D-dimer of 620 ng/mL FEU — using the Righini 2014 age-adjusted ADJUST-PE cutoff, can PE be excluded?","exampleUseCases":[{"title":"ED PE workup for elderly patient","prompt":"I have a 74-year-old patient with a D-dimer of 710 ng/mL FEU. Using the age-adjusted D-dimer cutoff from the ADJUST-PE study, does this value exclude pulmonary embolism?"},{"title":"Younger patient with borderline D-dimer","prompt":"My 43-year-old patient has a D-dimer of 490 ng/mL FEU in FEU units — can I use the Righini 2014 criteria to rule out PE with that result?"},{"title":"Automated clinical decision pipeline","prompt":"For a 58-year-old patient, calculate whether a D-dimer of 575 ng/mL FEU falls below the age-adjusted ADJUST-PE cutoff and tell me if PE is excluded."}],"resultDescription":"Returns the age-adjusted D-dimer cutoff in ng/mL FEU for the given patient age, whether the provided D-dimer value is strictly below the cutoff (PE excluded), and the rule applied (500 ng/mL if age <50, age×10 if age ≥50). Equality with the cutoff is NOT considered exclusion.","failureModes":["Age outside 18–120 integer range returns a validation error","D-dimer value outside 0–20000 range returns a validation error","D-dimer provided in DDU instead of FEU will produce clinically incorrect results (no unit conversion is performed)","Missing required query parameters (age or d_dimer_ng_ml) returns a 400-level error","Non-integer age value will fail schema validation"],"whenToPreferThis":"Use this endpoint when you need to apply the Righini 2014 ADJUST-PE age-adjusted D-dimer cutoff specifically — i.e., the rule that raises the threshold to age×10 ng/mL FEU for patients aged 50 and above. Prefer this over generic D-dimer lookups when the clinical context is PE rule-out in a low-to-intermediate pretest probability patient and D-dimer values are already in FEU (ng/mL). Do not use for YEARS criteria, Wells score, DDU units, or any diagnostic purpose beyond supporting the ADJUST-PE decision rule.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-09-15T01:00:11.882Z","isFirstParty":false}