{"uid":"cap_72JPrHDwKAK7hMsZeZGEB","slug":"magent-r-iss-calculator-8dd18bd8","name":"magent R-ISS Calculator","description":"Deterministic published-formula arithmetic plus ICD-10-CM, RxNorm, and LOINC. Pay in USDC on Base via x402.","url":"https://api.magentlab.com/api/calc/r_iss?utm_source=zero.xyz","method":"GET","headers":{},"bodySchema":{"type":"object","$schema":"https://json-schema.org/draft/2020-12/schema","required":["input"],"properties":{"input":{"type":"object","required":["type","method"],"properties":{"type":{"type":"string","const":"http"},"method":{"enum":["GET","HEAD","DELETE"],"type":"string"},"headers":{"type":"object","additionalProperties":{"type":"string"}},"queryParams":{"type":"object","required":["beta2_microglobulin_mg_l","high_risk_ca","ldh_gt_uln"],"properties":{"ldh_gt_uln":{"type":"boolean","description":"Serum LDH greater than the upper limit of normal as assigned by the caller (Palumbo 2015: high LDH is > ULN). magent does not assay LDH or assign ULN."},"albumin_g_l":{"type":"number","description":"Serum albumin in g/L (10-60). Converted as g/dL = g/L / 10. Provide this or albumin_g_dl, not both."},"albumin_g_dl":{"type":"number","description":"Serum albumin in g/dL (1-6). Provide this or albumin_g_l, not both. ISS uses g/dL. Stage I requires albumin >= 3.5 when Sβ2M < 3.5. Ignored when Sβ2M >= 5.5."},"high_risk_ca":{"type":"boolean","description":"High-risk cytogenetic abnormalities as assigned by the caller: true iff del(17p) and/or t(4;14) and/or t(14;16) by iFISH (Palumbo 2015). magent does not FISH."},"beta2_microglobulin_mg_l":{"type":"number","description":"Serum beta-2 microglobulin in mg/L (0.2-40). Greipp 2005 / Palumbo 2015 ISS. Stage I requires < 3.5; stage III when >= 5.5. magent does not assay beta-2 microglobulin."}}}},"additionalProperties":false},"output":{"type":"object","required":["type"],"properties":{"type":{"type":"string"},"example":{"type":"object"}}}}},"responseSchema":{"type":"json","example":{"path":"/api/calc/r_iss","count":2,"items":[{"formula":"r_iss","citation":{"id":"palumbo-2015","doi":"10.1200/JCO.2015.61.2267","pmid":"26240224","title":"Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group","source":"J Clin Oncol. 2015;33(26):2863-2869","authors":"Palumbo A, Avet-Loiseau H, Oliva S, et al."},"iss_stage":1,"disclaimer":"Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.","ldh_gt_uln":false,"riss_stage":1,"albumin_g_dl":4,"high_risk_ca":false,"iss_stage_label":"I","riss_stage_label":"I","formula_expression":"R-ISS I: ISS I AND high_risk_ca false AND ldh_gt_uln false; R-ISS III: ISS III AND (high_risk_ca OR ldh_gt_uln); R-ISS II: all other combinations. ISS I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; ISS III: beta2_microglobulin_mg_l >= 5.5; ISS II: neither I nor III (Palumbo 2015; ISS as Greipp 2005)","beta2_microglobulin_mg_l":2},{"formula":"r_iss","citation":{"id":"palumbo-2015","doi":"10.1200/JCO.2015.61.2267","pmid":"26240224","title":"Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group","source":"J Clin Oncol. 2015;33(26):2863-2869","authors":"Palumbo A, Avet-Loiseau H, Oliva S, et al."},"iss_stage":1,"disclaimer":"Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.","ldh_gt_uln":false,"riss_stage":1,"albumin_g_dl":4,"high_risk_ca":false,"iss_stage_label":"I","riss_stage_label":"I","formula_expression":"R-ISS I: ISS I AND high_risk_ca false AND ldh_gt_uln false; R-ISS III: ISS III AND (high_risk_ca OR ldh_gt_uln); R-ISS II: all other combinations. ISS I: beta2_microglobulin_mg_l < 3.5 AND albumin_g_dl >= 3.5; ISS III: beta2_microglobulin_mg_l >= 5.5; ISS II: neither I nor III (Palumbo 2015; ISS as Greipp 2005)","beta2_microglobulin_mg_l":2}]}},"example":null,"exampleRequest":null,"tags":["x402"],"displayCostAmount":"0.005","displayCostAsset":"USDC","priceDynamic":false,"priceHint":null,"priceStatus":"priced","priceSource":"probe","requiresHandshake":false,"reviewCount":0,"rating":{"score":"0.00","successRate":"0.00","reviews":0,"stars":null,"state":"unrated"},"availabilityStatus":"unknown","priceObserved":null,"sessionDeposit":null,"pricing":{"kind":"static","summary":"$0.005/call","primary":{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"},"accepted":[{"kind":"static","protocol":"x402","network":"base","amountUsd":"0.005","per":"call","confidence":"exact"}]},"paymentMethods":[{"uid":"pm_Ve5oCoySEa2BuuTgidHa2","protocol":"x402","methodType":"crypto","chain":"base","mode":"charge","costAmount":"0.005","costPer":"request","priority":0,"asset":"0x833589fCD6eDb6E08f4c7C32D4f71b54bdA02913","unit":"request","depositMicros":null,"planRef":null}],"brandName":null,"brandSlug":null,"brandBaseUrl":null,"brandDocsUrl":null,"whatItDoes":"Computes the Revised International Staging System (R-ISS) stage for multiple myeloma using beta-2 microglobulin, albumin, LDH status, and cytogenetic risk (Palumbo 2015).","exampleAgentPrompt":"Calculate the R-ISS stage for a multiple myeloma patient with a serum beta-2 microglobulin of 3.0 mg/L, albumin of 4.0 g/dL, LDH within normal limits, and no high-risk cytogenetic abnormalities (no del(17p), t(4;14), or t(14;16)).","exampleUseCases":[{"title":"Automated myeloma staging in clinical workflow","prompt":"Stage this myeloma patient using R-ISS: beta-2 microglobulin is 6.2 mg/L, albumin is 3.2 g/dL, LDH is above the upper limit of normal, and iFISH shows a t(4;14) translocation — so high-risk cytogenetics is true."},{"title":"Research cohort R-ISS classification","prompt":"I have a myeloma research patient with beta-2 microglobulin of 2.8 mg/L, serum albumin of 38 g/L, LDH not elevated, and no high-risk cytogenetic abnormalities — what is their ISS and R-ISS stage according to Palumbo 2015?"},{"title":"Prognostic stratification at diagnosis","prompt":"For a newly diagnosed myeloma patient, beta-2 microglobulin is 5.8 mg/L, albumin is 3.8 g/dL, LDH is normal, and del(17p) is detected on FISH — compute their R-ISS stage."}],"resultDescription":"Returns a JSON object with the computed ISS stage (1–3) and R-ISS stage (1–3) along with their string labels, the echo of input values, the full formula expression applied, a citation to Palumbo 2015 (DOI and PMID), and a clinical disclaimer noting this is deterministic formula output and not a medical device.","failureModes":["Missing required parameters (beta2_microglobulin_mg_l, high_risk_ca, or ldh_gt_uln) returns a validation error","Beta-2 microglobulin value outside range 0.2–40 mg/L may produce an error or unexpected result","Providing both albumin_g_l and albumin_g_dl simultaneously is disallowed and returns an error","Albumin value outside g/dL range 1–6 or g/L range 10–60 may be rejected","Non-boolean values for high_risk_ca or ldh_gt_uln cause type validation failure"],"whenToPreferThis":"Use this endpoint when you need a deterministic, citation-backed R-ISS stage computation per Palumbo 2015 for a multiple myeloma patient and you already have the serum beta-2 microglobulin, albumin, LDH-vs-ULN status, and iFISH cytogenetic risk classification in hand. Do not use if you need the R2-ISS (2022 revision), Durie-Salmon staging, or if you need laboratory assay of any of the input values — this endpoint only computes the formula, it does not perform any laboratory testing.","instructions":null,"reviewSummary":null,"reviewSummaryHighlights":null,"reviewSummaryConcerns":null,"reviewSummaryGeneratedAt":null,"activationCount":0,"lastUsedAt":null,"lastSuccessfullyRanAt":null,"lastHealthCheckAt":"2026-10-12T18:50:59.776Z","isFirstParty":false,"canonicalSlug":"magent-r-iss-calculator-8dd18bd8"}